The effects of administering cholesterol and cholesta-3:5-dien-7-one to cockerels

A constituent of the unsaponifiable portion of animal tissue lipids (λmax. 272mμ.)

“…It is clear, however, that the livers and kidneys of vitamin A-deficient rats are a fairly good source, and the same substance has been observed in hen liver and kidney. It also occurs (Kantiengar, Lowe, Morton & Pitt, 1955) in cockerel liver and kidney and in guinea pig liver (Leat, private communication). The present work records properties aiming at characterizing the 272 mp.…”

Unsaponifiable constituents of liver; ubiquinone and substance SC in various species

“…The latter is stable in alkaline solution and its spectrum in concentrated sulphuric acid has a characteristic peak at 356m,u; ubiquinone-containing fractions, on the other hand, show no maximum at 356 mr/ in concentrated sulphuric acid, but usually have a band with A,. at 315 mru (Kantiengar, Lowe, Morton & Pitt, 1955).…”

Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis

“…There are conflicting reports as to whether diet-derived cholesterol-oxidation products (oxysterols) initiate early atherosclerotic lesion and accelerate the lesion to the advanced lesion, as reviewed by Brown & Jessup (1999) and Schroepfer (2000). According to Brown & Jessup (1999), of thirteen studies using rabbits, quail, pigeons, rats, cockerels, hares and chickens, six indicated a proatherogenic effect of dietary oxysterols (Cook & MacDougall, 1968;Imai et al 1976;Shih, 1980;Jacobson et al 1985;Matthias et al 1987;Mahfouz et al 1997), four an antiatherogenic effect (Aramaki et al 1967;Griminger & Fisher, 1986;Higley et al 1986;Tipton et al 1987) and three indicated no clear-cut action (Kantiengar et al 1955;Imai & Lee, 1983;Sunde & Lalich, 1985). According to Brown & Jessup (1999), the reasons for these discrepancies are not clear, but they cannot be explained by study design or duration, dosage or type of oxysterols fed, or the animal model employed.…”