The effects of adding tramadol to ropivacine on axillary brachial plexus blockade in uremic patients

Dikmen, Bayazıt; Gamlı, Mehmet; Horasanlı, Eyüp; Ornek, Dilsen; Pekel, M.

doi:10.1097/00003643-200706001-00330

Cited by 2 publications

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“…The studies included in this review originated from eight countries, i.e., Austria [ 31 ], France [ 29 ], Germany [ 28 ], India [ 16 , 27 ], Italy [ 22 , 30 ], Pakistan [ 17 ], Turkey [ 18 , 20 , 21 , 25 , 26 ], and Tunisia [ 19 , 24 ]. The patients had undergone various types of surgery, including repair of an arteriovenous fistula [ 25 ], carpal tunnel release [ 29 , 30 ], shoulder arthroplasty [ 22 ], and shoulder or upper extremity surgery [ 16 – 21 , 23 , 24 , 26 – 28 , 31 ]. There were no studies using an infraclavicular approach for BPB.…”

Section: Resultsmentioning

confidence: 99%

“…There were no studies using an infraclavicular approach for BPB. The details of BPB were recorded according to type of approach (axillary [ 17 , 18 , 20 , 21 , 24 – 26 , 28 – 31 ], interscalene [ 22 ], supraclavicular [ 16 , 19 , 23 , 27 ]), the technique used for nerve guidance (landmark [ 16 , 17 , 23 , 27 , 28 ], nerve stimulator [ 18 , 20 – 22 , 24 – 26 , 29 – 31 ] or ultrasound guidance [ 19 ]), type of LA (bupivacaine [ 16 , 27 ], levobupivacaine [ 20 , 22 ], lidocaine [ 19 , 24 ], mepivacaine [ 29 , 31 ], prilocaine [ 28 ], ropivacaine [ 18 , 23 , 25 , 26 , 30 ], or a mixture of LA agents [ 17 , 21 ]), dose of tramadol (50 mg [ 18 , 23 ], 100 mg, or 1.5 mg/kg [ 16 , 17 , 19 – 22 , 24 – 31 ]), and the definitions of sensory bl...…”

Section: Resultsmentioning

confidence: 99%

“…All 16 studies mentioned randomization [ 16 – 31 ], and 15 studies included the details of concealed allocation [ 16 – 19 , 21 – 31 ]. However, five studies were conducted without blinding for assessment of outcomes [ 17 , 23 , 25 , 30 , 31 ]. One study did not state the details of exclusion in the number in each group [ 29 ] and the other study reported selective outcomes [ 16 ] ( Fig 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…The duration of sensory block was defined using the pinprick test [ 16 – 19 , 21 , 24 , 25 , 27 , 29 ], recovery of sensation [ 23 , 26 , 28 , 30 ], and offset of paresthesia [ 30 ] ( Table 1 ). Adjuvant use of tramadol significantly prolonged the duration of sensory block by 61.5 min, with high heterogeneity (14 RCTs; 95% CI, -95.5 to -27.6; I 2 = 97%; P = 0.0004) ( Fig 3 ).…”

Section: Resultsmentioning

confidence: 99%

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Effect of tramadol as an adjuvant to local anesthetics for brachial plexus block: A systematic review and meta-analysis

Shin

Jang

et al. 2017

PLoS ONE

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BackgroundTramadol, a 4-phenyl-piperidine analog of codeine, has a unique action in that it has a central opioidergic, noradrenergic, serotonergic analgesic, and peripheral local anesthetic (LA) effect. Many studies have reported contradictory findings regarding the peripheral analgesic effect of tramadol as an adjuvant to LA in brachial plexus block (BPB). This meta-analysis aimed to evaluate the effects of tramadol as an adjunct to LA in BPB during shoulder or upper extremity surgery.MethodsWe searched the PubMed, EMBASE, Cochrane, KoreaMed databases, and Google Scholar for eligible randomized controlled trials (RCTs) that compared BPB with LA alone and BPB with LA and tramadol. Primary outcomes were the effects of tramadol as an adjuvant on duration of sensory block, motor block, and analgesia. Secondary outcomes were the effects of tramadol as an adjuvant on time to onset of sensory block and motor block and on adverse effects. We performed the meta-analysis using Review Manager 5.3 software.ResultsWe identified 16 RCTs with 751 patients. BPB with tramadol prolonged the duration of sensory block (mean difference [MD], -61.5 min; 95% CI, -95.5 to -27.6; P = 0.0004), motor block (MD, -65.6 min; 95% CI, -101.5 to -29.7; P = 0.0003), and analgesia (MD, -125.5 min; 95% CI, -175.8 to -75.3; P < 0.0001) compared with BPB without tramadol. Tramadol also shortened the time to onset of sensory block (MD, 2.1 min; 95% CI, 1.1 to 3.1; P < 0.0001) and motor block (MD, 1.2 min; 95% CI, 0.2 to 2.1; P = 0.010). In subgroup analysis, the duration of sensory block, motor block, and analgesia was prolonged for BPB with tramadol 100 mg (P < 0.05) but not for BPB with tramadol 50 mg. The quality of evidence was high for duration of analgesia according to the GRADE system. Adverse effects were comparable between the studies.ConclusionsIn upper extremity surgery performed under BPB, use of tramadol 100 mg as an adjuvant to LA appears to prolong the duration of sensory block, motor block, and analgesia, and shorten the time to onset of sensory and motor blocks without altering adverse effects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of tramadol as an adjuvant to local anesthetics for brachial plexus block: A systematic review and meta-analysis

Shin

Jang

et al. 2017

PLoS ONE

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“…The results of our study were entirely different from study by Dikmen et al . [ 16 ] who observed that the addition of 100 mg of tramadol to 3.75 mg/ml of ropivacaine does not have any beneficial effect on the nerve block characteristics of axillary brachial plexus anesthesia for arteriovenous fistula surgery in uremic patients.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of systemically and perineurally administered tramadol as an adjunct for supraclavicular brachial plexus block

Nagpal

Rana

Singh

et al. 2015

J Anaesthesiol Clin Pharmacol

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Background and Aims:The study was designed to compare the effects of tramadol administered as an adjunct to bupivacaine in supraclavicular block to that of systemic administration, on postoperative analgesia and rescue analgesic requirement following upper limb surgeries.Material and Methods:A prospective, randomized, controlled, double-blind study was undertaken in patients scheduled for upper limb surgeries under supraclavicular block. All the three group patients received either of the following drugs mixtures: Group A — bupivacaine 0.5%-18 ml + normal saline-7 ml for block and normal saline-10 ml intravenously. Group B — bupivacaine 0.5%-18 ml + normal saline-7 ml mixture for block and tramadol (100 mg) diluted to 10 ml — intravenously. Group C — bupivacaine 0.5%-18 ml + tramadol (100 mg) + normal saline-5 ml mixture and normal saline 10 ml intravenously. The patients were observed for sensory, motor onset along with the duration of sensory and motor block. Patients were monitored for sedation and hemodynamic parameters during intra-operative and postoperative period. Pain-free period and demand for rescue analgesia was noted in all the patients.Results:The study demonstrates that the mixture of tramadol and bupivacaine injected perineurally for supraclavicular brachial plexus block hastens the onset of sensory block, motor block and provides a longer duration of motor blockade and demand for rescue analgesia as compared to other two groups.Conclusions:In conclusion, the addition of tramadol to bupivacaine mixtures as an adjunct for supraclavicular brachial plexus block provide better postoperative analgesia for orthopedic upper extremity surgery in comparison to control or systemic tramadol group without any side effects.

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The effects of adding tramadol to ropivacine on axillary brachial plexus blockade in uremic patients

Cited by 2 publications

References 0 publications

Effect of tramadol as an adjuvant to local anesthetics for brachial plexus block: A systematic review and meta-analysis

Effect of tramadol as an adjuvant to local anesthetics for brachial plexus block: A systematic review and meta-analysis

Comparative study of systemically and perineurally administered tramadol as an adjunct for supraclavicular brachial plexus block

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