The effects of acute exercise on bone turnover markers in middle-aged and older adults: A systematic review

Smith, Cassandra; Tacey, Alexander; Mesinovic, Jakub; Scott, David; Lin, Xuzhu; Brennan‐Speranza, Tara C.; Lewis, Joshua R.; Duque, Gustavo; Levinger, Itamar

doi:10.1016/j.bone.2020.115766

Cited by 27 publications

(26 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The alterations in BTMs after training were most pronounced in the young participants. This indicates that the acute effects of training on bone turnover decrease by age, as also suggested in a recent systematic review by Smith et al (19). In both groups of young participants, we observed an immediate decrease in the serum bone resorption marker CTX-1 c after both training modes, which returned to baseline level after 24 h. A decline in P1NP c levels was also seen in these groups after ST.…”

Section: Age and Sex Differences In Training-induced Changes In Serum...supporting

confidence: 89%

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

et al. 2022

View full text Add to dashboard Cite

ContextExercise is recognized as an important strategy to prevent bone loss, but its acute effects on bone turnover markers (BTMs) and related markers remain uncertain.ObjectiveTo assess the acute effects of two different exercise modes on BTMs and related markers in young adults of both sexes and elderly men.Design, Setting, ParticipantsThis was a three-group crossover within-subjects design study with a total of 53 participants—19 young women (aged 22–30), 20 young men (aged 21–30 years), and 14 elderly men (aged 63–74 years)—performing two different exercise sessions [strength training (ST) and high-intensity interval training (HIIT)] separated by 2 weeks, in a supervised laboratory setting.Main Outcome MeasuresPlasma volume-corrected serum measurements of the BTMs C-terminal telopeptide of type 1 collagen (CTX-I) and procollagen of type 1 N-terminal propeptide (P1NP), total osteocalcin (OC), sclerostin, and lipocalin-2 (LCN2) at baseline, immediately after, and 3 and 24 h after each of the two exercise modes were performed.Results and ConclusionAnalyses revealed sex- and age-dependent differences in BTMs and related bone markers at baseline and time-, sex-, and age-dependent differences in response to exercise. No differences between exercise modes were observed for BTM response except for sclerostin in young men and LCN2 in elderly men. An acute, transient, and uniform increase in P1NP/CTX-1 ratio was found in young participants, demonstrating that beneficial skeletal effects on bone metabolism can be attained through both aerobic endurance and resistance exercise, although this effect seems to be attenuated with age. The acute effects of exercise on bone-related biomarkers were generally blunted after 24 h, suggesting that persistent alterations following prolonged exercise interventions should be assessed at later time points.

show abstract

Section: Age and Sex Differences In Training-induced Changes In Serum...supporting

confidence: 89%

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

et al. 2022

View full text Add to dashboard Cite

show abstract

“…These increases persist for 24 hr and possibly for as long as 72 hr. It is therefore important to enquire about regular exercise and ask the subject to refrain from exercise for at least 24 hr before samples are collected [63].…”

Section: Controllable Sources Of Biological Variabilitymentioning

confidence: 99%

Bone, it’s Architecture, Markers of Resorption and Their Role in Osteoporosis in India: A Detailed Review

Rai

Dsa

Sujir

2021

JPRI

View full text Add to dashboard Cite

Bone is a dynamic tissue that undergoes constant remodeling throughout the life span. Bone turnover is an equilibrium between the rates of bone formation and resorption. Assay of bone turnover markers (BTMs) is very important as they provide an insight in to the dynamics of bone turnover in many metabolic bone disorders. An increase in bone turnover seen with aging and pathological states such as osteoporosis leads to deterioration of bone microarchitecture and thus contributes to an increase in the risk of fracture independent of low bone mineral density (BMD). These microarchitectural alterations affecting the bone quality can be assessed by BTMs and thus may serve as a complementary tool to BMD in the assessment of fracture risk. Osteoporosis is a major health problem in India with 230 million people getting affecting. Women get more crippled as they show an additional accelerated phase of bone loss, which occurs 10 years earlier in India. Bone health in Indian women is more appalling with deficient nutritional status as compared to their counterparts. Biochemical assays are non-invasive, not site specific, reflect the turnover of entire skeleton, can detect early changes in the bone turnover. The present review was aimed to discuss the normal architecture of bone, markers of it’s turnover and their role in osteoporosis in India.

show abstract

“…Many studies also reported the effects of acute resistance oraerobic exercises on changes in bone markers in the blood. [8][9][10][11][12] It appears that training effects are reinforced by responses after an acute exercise bout 10 ; it seems possible that the investigation of changes in bone markers in the blood after an exercise bout gives us preliminary ideas about bone metabolism after exercise training.…”

Section: Introductionmentioning

confidence: 99%

Changes in blood bone markers after the first and second bouts of whole‐body eccentric exercises

Huang

Nosaka

Chen

2022

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

show abstract

The effects of acute exercise on bone turnover markers in middle-aged and older adults: A systematic review

Cited by 27 publications

References 89 publications

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

Acute Effects of Strength and Endurance Training on Bone Turnover Markers in Young Adults and Elderly Men

Bone, it’s Architecture, Markers of Resorption and Their Role in Osteoporosis in India: A Detailed Review

Changes in blood bone markers after the first and second bouts of whole‐body eccentric exercises

Contact Info

Product

Resources

About