The effects of acute corticosterone on lithium chloride-induced conditioned place aversion and locomotor activity in rats

Tenk, Christine M.; Kavaliers, Martin; Ossenkopp, Klaus‐Peter

doi:10.1016/j.lfs.2006.03.008

Cited by 22 publications

(10 citation statements)

References 48 publications

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“…The corticosterone-treated animals also showed a suppression of evoked fos expression in the PVH and a disinhibition of fos expression in the piriform cortex, a brain region involved in positively motivated behavior. These results confirm findings with genetically modified mice that have implicated corticosteroid action in antidepressant effects (Mueller and Holsboer, 2006) and are consistent with several reports of behaviorally activating (Deroche et al, 1992;Sandi et al, 1996;Tenk et al, 2006), anti-stress (Schelling et al, 2001;Johnson et al, 1996;Stone et al, 2002), mood-elevating effects of corticosteroids (Het and Wolf, 2007). It is also of interest that diurnal corticosterone increases appear to be essential for increases in neurogenesis elicited by serotonin selective antidepressants (Huang and Herbert, 2006), an effect that appears necessary for antidepressant action.…”

Section: Extension To Corticosteroidssupporting

confidence: 91%

A final common pathway for depression? Progress toward a general conceptual framework

Stone

Yang

Quartermain

2008

Neuroscience & Biobehavioral Reviews

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Functional neuroimaging studies of depressed patients have converged with functional brain mapping studies of depressed animals in showing that depression is accompanied by a hypoactivity of brain regions involved in positively motivated behavior together with a hyperactivity in regions involved in stress responses. Both sets of changes are reversed by diverse antidepressant treatments. It has been proposed that this neural pattern underlies the symptoms common to most forms of the depression, which are the loss of positively motivated behavior and increased stress. The paper discusses how this framework can organize diverse findings ranging from effects of monoamine neurotransmitters, cytokines, corticosteroids and neurotrophins on depression. The hypothesis leads to new insights concerning the relationship between the prolonged inactivity of the positive motivational network during a depressive episode and the loss of neurotrophic support, the potential antidepressant action of corticosteroid treatment, and to the key question of whether antidepressants act by inhibiting the activity of the stress network or by enhancing the activity of the positive motivational system. Keywords depression; neuroimaging; fos; final common pathway; cytokines; corticosteroids; monoamines; neurotrophins; theory The quest for a final common pathway has long been goal of research in depression. Famous candidates in this search have included dysregulated brain monoamines (Schildkraut, 1965;

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Section: Extension To Corticosteroidssupporting

confidence: 91%

A final common pathway for depression? Progress toward a general conceptual framework

Stone

Yang

Quartermain

2008

Neuroscience & Biobehavioral Reviews

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“…The author also confirmed this in a preclinical study showing that corticosterone addition to the drinking water at low doses markedly reduces immobility in the mouse forced swim test [130,131] . These results confirm findings with genetically modified mice that have implicated corticosteroid action in antidepressant effects [125] and are consistent with several reports of behaviorally activating [132][133][134] , antistress [135][136][137] , mood-elevating effects of corticosteroids [138] .…”

Section: Corticosteroidssupporting

confidence: 92%

A final common pathway for depression: implications for therapy

Stone

2007

Expert Opinion on Therapeutic Targets

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Depression in humans and animal models has been found to be accompanied by a hypoactivity of brain regions involved in positively motivated behavior together with a hyperactivity in regions involved in stress responses. Both sets of changes are reversed by diverse antidepressant treatments. It has been proposed that this neural pattern underlies the symptoms common to most forms of depression, which are the loss of positively motivated behavior and the increase in stress. The present paper discusses how this framework can organize diverse findings on the multiple factors associated with this disorder. The hypothesis suggests new therapeutic strategies involving treatment with low-dose corticosteroids to suppress the stress network or with antagonists of alpha(1A)- and agonists of alpha(1B)-adrenoceptors to disinhibit or activate the positive motivational network, respectively.

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“…This is in contrast to the effects of primarily emetic stimuli, such as lithium chloride (LiCl), which result in both conditioned place and taste avoidance (CPA and CTA, respectively; Parker, 2003; Tenk et al, 2005, 2006). Conversely, drug self-administration under some conditions can increase the acceptance of paired orosensory stimuli (Loney and Meyer, 2018), as defined by a relative reduction in rejection, suggestive of an increase in palatability.…”

Section: Introductionmentioning

confidence: 93%

Nicotine pre-treatment reduces sensitivity to the interoceptive stimulus effects of commonly abused drugs as assessed with taste conditioning paradigms

Loney¹,

Meyer²

2019

Drug and Alcohol Dependence

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Background: Drug pre-exposure attenuates sensitivity to the interoceptive stimulus properties of additional subsequently administered drugs in drug-induced conditioned taste avoidance (CTA) and conditioned place preference (CPP) paradigms. Specifically, nicotine, commonly used in conjunction with other addictive substances, attenuates acquisition of ethanol and caffeine As and morphine-induced CPP. Methods: Because nicotine use is comorbid with a number of substance use disorders, we systematically examined the effects of nicotine pre-exposure on two different conditioning paradigms involving integration of the interoceptive stimulus properties of multiple commonly abused drugs, in male and female rats, designed to examine both the aversive and reinforcing properties of these drugs. Results: Nicotine dose-dependently interfered with acquisition of CTA to passively administered morphine, ethanol, and cocaine, but not lithium chloride, demonstrating that the effects of nicotine are not simply a matter of reduced orosensory processing or an inability to learn such associations. Moreover, nicotine-treated rats required higher doses of drug in order to develop CTA and did not show increased acceptance of the taste of self-administered ethanol compared with saline-treated rats. Conclusions: These data demonstrate that nicotine pre-exposure attenuates sensitivity to the stimulus effects of multiple drugs in two conditioning paradigms, in a manner which is consistent with a reduced ability to integrate the interoceptive properties of abused drugs. Through reducing these stimulus properties of drugs of abuse, concomitant nicotine use may result in a need to increase either the frequency or strength of doses during drug-taking, thus likely contributing to enhanced addiction liability in smokers.

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The effects of acute corticosterone on lithium chloride-induced conditioned place aversion and locomotor activity in rats

Cited by 22 publications

References 48 publications

A final common pathway for depression? Progress toward a general conceptual framework

A final common pathway for depression? Progress toward a general conceptual framework

A final common pathway for depression: implications for therapy

Nicotine pre-treatment reduces sensitivity to the interoceptive stimulus effects of commonly abused drugs as assessed with taste conditioning paradigms

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