The effects of acute corticosteroid therapy for asthma on serum immunoglobulin levels

Posey, William Campbell; Nelson, Harold S.; Branch, Bernard; Pearlman, David S.

doi:10.1016/0091-6749(78)90134-3

Cited by 100 publications

(59 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several groups have already reported the suppression of humoral immunity, i.e. low serum immunoglobulin levels, in patients with severe asthma treated with oral PSL [6, 7, 8, 9, 10, 11, 12, 13]. The present study demonstrated that the daily dose (12.5 mg), but not the duration of oral PSL was the determinant factor of low serum IgG levels in severe asthma.…”

Section: Discussionsupporting

confidence: 50%

Hypogammaglobulinemia in Steroid-Dependent Asthmatics Correlates with the Daily Dose of Oral Prednisolone

Kawano

Matsuse²,

Obase³

et al. 2002

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Steroid-induced adverse effects including suppression of humoral immunity should be considered in steroid-dependent severe asthma. Only a few studies have determined the exact steroid dose that could potentially suppress humoral immunity in asthmatics. Methods: Randomly selected 100 adult asthmatics treated with inhaled beclomethasone dipropionate (BDP) were classified into three groups based on the dose of steroid to determine the serum IgG, IgA and IgM levels by radioimmunoassay. Relationships between serum immunoglobulin levels and the daily dose and duration of oral prednisolone (PSL) therapy were examined. Results: None of the patients on inhaled corticosteroid alone had hypogammaglobulinemia. Patients on oral PSL at a dose >12.5 mg/day for at least 1 year had low serum IgG. There was no significant correlation between the duration of oral PSL therapy and serum IgG. Conclusions: Oral PSL can potentially suppress humoral immunity in severe asthma. In asthmatics, hypogammaglobulinemia could develop in those on a daily dose of PSL >12.5 mg, but is independent of the duration of such treatment. No suppression of humoral immunity was noted on inhaled corticosteroid therapy alone, either at low or high dose.

show abstract

Section: Discussionsupporting

confidence: 50%

Hypogammaglobulinemia in Steroid-Dependent Asthmatics Correlates with the Daily Dose of Oral Prednisolone

Kawano

Matsuse²,

Obase³

et al. 2002

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Table 1: Mean ± standard deviation of total white blood cell count, CD4 cell count and serum cortisol level at Stages A, B and C. (Table 1) could be attributed to the effect of prolonged serum cortisol secretion from the adrenal cortex which could be linked to stress associated with preparation for examination resulting in significant physiological changes. This is in accordance with the findings of Scott (2011),where cortisol is released in response to stressful events, coupled with the diversion of glucose from low priority organs in other to regain homeostasis .Cortisol prevents the proliferation of T cells by rendering the interleukin 2 producer Tcells unresponsive to interleukin -1 and unable to produce the T cell growth factor (Palacious and Sugawera 1982) and inhibits immunoglobulin A and immunoglobulin M in serum (Posey et. al., 1978).The immune system is merely responding to the effect of stressor, during which most of the adaptation leads to greater fitness, if balance diet and resting are observed (Ehiaghe et.…”

Section: Discussionsupporting

confidence: 77%

Effect of stress of examination on serum cortisol level and cd4 cell count in male undergraduates at Igbinedion University, Nigeria

Ehiaghe¹,

K.A²,

Ij³

2014

Afr. J. Cell. Path

View full text Add to dashboard Cite

Aim:To assess the effect of stress of examination on serum cortisol level and CD4 cell count in young male students at Igbinedion University. Methods: A cross sectional laboratory based analysis was adopted for this study. A total of 204 male undergraduate volunteers (age 22 + 1.0 years, body mass index 23 + 0.5 kg/m 2 ) were randomly recruited for the study. Total white blood cell (TWBC) was determined using the sysmex® Automated Hematology Analyzer. CD4 cell count was estimated using Partec cyflow counter, while serum cortisol level was determined by enzyme linked immuno sorbent assay technique. Results: There was a significant increase (P < 0.05) in the serum cortisol level at Stage A (1 st day of the semester) when compared with Stage B (midway in the semester) and Stage C (morning of the examination), while there was significant decrease (P < 0.05) in the TWBC count and CD4 cell count at Stage A when compared with Stage B and Stage C. Conclusion: The stress of examination inhibits proliferation of CD4 cells with the elevation of serum cortisol as a possible mediator.

show abstract

“…Although prednisone has been widely recognized as a cause of reduced immunoglobulin levels [25,35], a relation between prednisone use and a low response to pneumococcal vaccination has not been established previously [34,36,37]. In this study it was found that prednisone use at the time of vaccination was significantly more prevalent in patients with a low overall response to their pneumococcal vaccination.…”

Section: Discussionsupporting

confidence: 52%

“…Medication use and smoking status were extracted from internal patient reports. Patients who were classified as receiving prednisone therapy started this at least 2 weeks before vaccination [24,25]. A patient was classified as an ex-smoker in case of smoking cessation for at least 6 months prior to vaccination.…”

Section: Classification Of Clinical Characteristicsmentioning

confidence: 99%

Response to pneumococcal vaccination in mannose-binding lectin-deficient adults with recurrent respiratory tract infections

Kessel

Hoffman

Velzen‐Blad

et al. 2014

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryMannose-binding lectin (MBL)-deficiency is associated with an increased susceptibility to pneumococcal infections and other forms of disease. Pneumococcal vaccination is recommended in MBL-deficient patients with recurrent respiratory tract infections (RRTI). The response to pneumococcal vaccination in MBL-deficient individuals has not yet been studied in detail. An impaired response to pneumococcal polysaccharides in MBL-deficient patients might explain the association between MBL deficiency and pneumococcal infections. This study investigates the antibody response to pneumococcal vaccination in MBL-deficient adult patients with RRTI. Furthermore, we investigated whether there was a difference in clinical presentation between MBL-deficient and -sufficient patients with RRTI. Eighteen MBL-deficient and 63 MBL-sufficient adult patients with RRTI were all vaccinated with the 23-valent pneumococcal polysaccharide vaccine and antibodies to 14 pneumococcal serotypes were measured on a Luminex platform. There were no differences observed in the response to pneumococcal vaccination between MBL-sufficient and -deficient patients. Forty-three MBLsufficient patients could be classified as responders to pneumococcal vaccination and 20 as low responders, compared to 15 responders and three low responders in the MBL-deficient patients. We found no clear difference in clinical, radiological, lung function and medication parameters between MBL-sufficient and -deficient patients. In conclusion, our study suggests that MBL-deficient adults with RRTI have a response to a pneumococcal capsular polysaccharide vaccine comparable with MBL-sufficient patients. Moreover, we did not find a clear clinical role of MBL deficiency in adults with RRTI. As MBL deficiency is associated with an increased susceptibility to pneumococcal infections, pneumococcal vaccination might be protective in MBL-deficient patients with RRTI.

show abstract

The effects of acute corticosteroid therapy for asthma on serum immunoglobulin levels

Cited by 100 publications

References 22 publications

Hypogammaglobulinemia in Steroid-Dependent Asthmatics Correlates with the Daily Dose of Oral Prednisolone

Hypogammaglobulinemia in Steroid-Dependent Asthmatics Correlates with the Daily Dose of Oral Prednisolone

Effect of stress of examination on serum cortisol level and cd4 cell count in male undergraduates at Igbinedion University, Nigeria

Response to pneumococcal vaccination in mannose-binding lectin-deficient adults with recurrent respiratory tract infections

Contact Info

Product

Resources

About