The effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of rats

Toker, Aysun; AKÇAY, FATİH; AKSOY, HÜLYA; SÜLEYMAN, HALİS; ÖZGEN, UFUK; Erdem, Havva

doi:10.3906/sag-1203-89

Cited by 4 publications

(1 citation statement)

References 35 publications

(22 reference statements)

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“…Cadirci et al [73] found that hexane-dichloromethane root extract of O. armeniacum has a protective effect against oxidative stress generated by ethanol in the stomach of Wistar rats by inhibiting malondialdehyde (MDA) levels in stomach tissue. Toker et al [63] conclude that acetyl shikonin collected from species O. armeniacum has an antiulcer effect by increasing antioxidant activity and level of nitric oxide and suppressing oxidative marker (malondialdehyde) in the stomach of male Wistar rats. Rinner et al [74] reported that petroleum ether fraction of plant O. paniculatum showed antiproliferative potential via enhancing the procaspase-3 cleavage in HT-29, 769-P, WM35, WM 164, Hela, SBc-L2, WM9, and THP-1 cell lines.…”

Section: Ethnopharmacology Of Genus O With Special Reference To Cancermentioning

confidence: 99%

Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight

Kumar

Attri

Kaur

et al. 2022

Exploration of Targeted Anti-Tumor Therapy

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Onosma (O.) is a genus of perennial flowering plants in the family Boraginaceae with approximately 250 species widely dispersed in temperate, tropical, and subtropical areas. It is traditionally used to treat rheumatism, fever, asthma, stomach irritation, and inflammatory ailments. The bioactive constituents present in the genus O. include benzoquinones, naphthazarins, alkaloids, phenolic, naphthoquinones, and flavonoids whereas shikonins and onosmins are the most significant. The review compiled contemporary research on O. L., including its distribution, morphology, traditional applications, phytochemistry, ethnopharmacology, and toxicology. This review also highlights a few critical challenges and possible future directions for O. L. research. Modern research has demonstrated a wide range of pharmacological effects of different species of O. L., including anti-diabetic, anticancer, anti-inflammatory, and cardiovascular protective. However, the studies on the O. genus are still not fully explored, therefore, researchers need to discover novel products with their toxicity studies, molecular mechanism, and associated side effects. Future exploration of potent constituents from this genus and clinical trials are required to explore its pharmacological importance.

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Section: Ethnopharmacology Of Genus O With Special Reference To Cancermentioning

confidence: 99%

Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight

Kumar

Attri

Kaur

et al. 2022

Exploration of Targeted Anti-Tumor Therapy

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Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells

Wang

Pan

Liang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Acetylcholinesterase inhibitors are prominent alternative in current clinical treatment for AD patients. Therefore, there is a continued need to search for novel AChEIs with good clinical efficacy and less side effects. By using our in-house natural product database and AutoDock Vina as a tool in docking study, we have identified twelve phytochemicals (emodin, aloe-emodin, chrysophanol, and rhein in Rhei Radix Et Rhizoma; xanthotoxin, phellopterin, alloisoimperatorin, and imperatorin in Angelicae dahuricae Radix; shikonin, acetylshikonin, isovalerylshikonin, and β,β-dimethylacrylshikonin in Arnebiae Radix) as candidates of AChEIs that were not previously reported in the literature. In addition to AChEI activity, a series of cell-based experiments were conducted for the investigation of their neuroprotective activities. We found that acetylshikonin and its derivatives prevented apoptotic cell death induced by hydrogen peroxide in human and rat neuronal SH-SY5Y and PC12 cells at 10 μM. We showed that acetylshikonin exhibited the most potent antiapoptosis activity through the inhibition of the generation of reactive oxygen species as well as protection of the loss of mitochondria membrane potential. Furthermore, we identified for the first time that the upregulation of heme oxygenase 1 by acetylshikonin is a key step mediating its antiapoptotic activity from oxidative stress in SH-SY5Y cells.

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Enchytraeus demutatus sp. nov. (Enchytraeidae, Oligochaeta) has characters hitherto unrecorded in the genus

Schmelz

Klinth

Chalkia

et al. 2019

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The effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of rats

Cited by 4 publications

References 35 publications

Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight

Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight

Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells

Enchytraeus demutatus sp. nov. (Enchytraeidae, Oligochaeta) has characters hitherto unrecorded in the genus

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