The Effects of a Whey Protein and Guar Gum-Containing Preload on Gastric Emptying, Glycaemia, Small Intestinal Absorption and Blood Pressure in Healthy Older Subjects

Abstract

A whey protein/guar gum preload reduces postprandial glycaemia in type 2 diabetes through slowing gastric emptying. However, gastric emptying has previously been assessed using a stable isotope breath test technique, which cannot discriminate between slowing of gastric emptying and small intestinal absorption. This preload also may be useful in the management of postprandial hypotension. We evaluated the effects of a whey protein/guar preload on gastric emptying, glucose absorption, glycaemic/insulinaemic and blood pressure (BP) responses to an oral glucose load. Eighteen healthy older participants underwent measurements of gastric emptying (scintigraphy), plasma glucose and insulin, glucose absorption, superior mesenteric artery (SMA) flow, BP and heart rate (HR) after ingesting a 50 g glucose drink, with or without the preload. The preload reduced plasma glucose (p = 0.02) and serum 3-O-methylglucose (3-OMG) (p = 0.003), and increased plasma insulin (p = 0.03). There was no difference in gastric emptying or BP between the two days. The reduction in plasma glucose on the preload day was related to the reduction in glucose absorption (r = 0.71, p = 0.002). In conclusion, the glucose-lowering effect of the preload may relate to delayed small intestinal glucose absorption and insulin stimulation, rather than slowing of gastric emptying.

Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus

“…Compared to GDM group, there was no signi cant difference in fasting blood glucose bewteen two groups, but postprandial blood glucose was decreased signi cantly during the entire experimental session. The results are consistent with previous studies that used whey protein preload [5,[10][11][12], but the mechanism is different. Some studies suggest that the hyperglycemia-reducing effect of whey protein preload may relate to insulin stimulation and delaying of glucose absorption in intestinal [13][14][15], and we have got similar result, plasma 2 h insulin was increased on days 5, 7 and 14 in GDM-W group, HOMA-IR decreased signi cantly on days 14 in the experimental session.…”

Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus

“…Compared to GDM group, there was no signi cant difference in fasting blood glucose bewteen two groups, but postprandial blood glucose was decreased signi cantly during the entire experimental session. The results are consistent with previous studies that used whey protein preload 5,[10][11][12] , but the mechanism is different. Some studies suggest that the hyperglycemia-reducing effect of whey protein preload may relate to insulin stimulation and delaying of glucose absorption in intestinal [13][14][15] , and we have got similar result, plasma 2h insulin was increased on days 5, 7 and 14 in GDM-W group, HOMA-IR decreased signi cantly on days 14 in the experimental session.…”

Whey protein preloading can alleviate stress adaptation disorder and improve hyperglycemia in women with gestational diabetes mellitus

“…Compared to GDM group, there was no signi cant difference in fasting blood glucose bewteen two groups, but postprandial blood glucose was decreased signi cantly during the entire experimental session. The results are consistent with previous studies that used whey protein preload [5,[10][11][12], but the mechanism is different. Some studies suggest that the hyperglycemia-reducing effect of whey protein preload may relate to insulin stimulation and delaying of glucose absorption in intestinal [13][14][15], and we have got similar result, plasma 2 h insulin was increased on days 5, 7 and 14 in GDM-W group, HOMA-IR decreased signi cantly on days 14 in the experimental session.…”