The Effects of a Multivitamin/Mineral Supplement on Micronutrient Status, Antioxidant Capacity and Cytokine Production in Healthy Older Adults Consuming a Fortified Diet

McKay, Diane L.; Perrone, Gayle; Rasmussen, Helen; Dallal, Gerard E.; Hartman, Wilburta J.; Cao, Guohua; Prior, Ronald L.; Roubenoff, Ronenn; Blumberg, Jeffrey B.

doi:10.1080/07315724.2000.10718959

Cited by 66 publications

(34 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In Australia, the number of aged care residents with low 25(OH)D levels is high, with estimates ranging between 22 and 74% (Stein et al, 1996;Flicker et al, 2003;. Only one previous study in community dwelling elderly assessed 25(OH)D concentrations following 8 weeks of MV supplementation, which found an increase in serum 25(OH)D of 30%, reducing the rates of serum 25(OH)D levels o37.5 nmol l À1 from 7 to 0% (McKay et al, 2000b). In that study, however, serum 25(OH)D levels were initially higher (77 nmol l À1 ) compared with our group (36 nmol l À1 ).…”

Section: Discussionmentioning

confidence: 99%

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

et al. 2007

View full text Add to dashboard Cite

Objectives: To assess the effectiveness of a multivitamin (MV) tablet on nutritional status, quantitative heel ultrasound (QUS), mobility, muscle strength and falls. The design comprised two groups matched on mobility levels, randomized to receive a daily MV or placebo (P) tablet for 6 months. The setting was an Australian residential care facility. Subjects: A total of 92 aged care residents. Serum micronutrients, body weight, QUS, rate of falls, hand grip strength, and the timed up and go test were assessed at baseline and 6 months. Results: A total of 49 participants consumed a MV and 43, a matched P for 6 months. There was a greater increase in the MV vs P group for serum 25(OH)D (mean difference ± standard error, 33.4 ± 2.6 nmol l À1 ), folate (13.4 ± 2.8 nmol l À1 ), and vitamin B12 (178.0±40.3 pmol l À1 ) (all Po0.001). Adequate 25(OH)D concentrations (X50 nmol l À1 ) were found among 77% of participants in the MV group vs 10% taking P (Po0.001). Adjusting for baseline levels, the increase in QUS was greater in the MV vs P group (3.0±2.0 dB MHz À1 vs À2.9±2.1 dB MHz À1 , respectively, P ¼ 0.041). There was a trend towards a 63% lower mean number of falls in the MV vs P group (0.3 ± 0.1 falls vs 0.8 ± 0.3 falls, P ¼ 0.078). Conclusions: MV supplementation raised serum vitamin B12 and folate concentrations and increased serum 25(OH)D, which was accompanied by an apparent positive effect on bone density. We also found a trend towards a reduction in falls and this could contribute to a reduction in fractures.

show abstract

Section: Discussionmentioning

confidence: 99%

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

et al. 2007

View full text Add to dashboard Cite

show abstract

“…There are reports from several studies assessing intakes of specific supplements in relation to disease diagnosis (eg, antioxidants, folate, calcium, or vitamin D) (26,29,30). People with a disease condition may be more likely to take a supplement with a research record than a herbal/botanical/nontraditional supplement with an uncertain or unknown influence on health (31).…”

Section: Discussionmentioning

confidence: 99%

“…It has been stated that supplementation with a formulation that is close to 100% Daily Value can reduce prevalence of suboptimal micronutrient status, particularly among older adults (31). However, if nutrient intake is already adequate, then it is questionable whether supplement use improves micronutrient profile (32).…”

Section: Discussionmentioning

confidence: 99%

Association of Dietary Supplement Use with Specific Micronutrient Intakes among Middle-Aged American Men and Women: The INTERMAP Study

Archer¹,

Stamler²,

Moag-Stahlberg³

et al. 2005

Journal of the American Dietetic Association

View full text Add to dashboard Cite

show abstract

“…For AA analysis, plasma was immediately treated with 500 mM perchloric acid (1:1 v/v) and then determined using a HPLC system with an electrochemical detector (Bioanalytical system, N. Lafayette, IN). 34 Plasma BC, AT, retinol (ROH) and retinyl palmitate (RP) were measured by HPLC as previously described. 7,35 Briefly, a 50 ll aliquot of extract reconstituted with ethanol was injected into a gradient reverse-phase HPLC system, consisting of a Waters 2695 separation module, a Waters 2996 photodiode array detector (Waters Corporate, Milford, MA) and a 0.46 3 8.3 cm 2 pecosphere-3 C18 cartridge column (PerkinElmer Analytical Instruments, Shelton, CT).…”

Section: Bc At and Aa Supplementationmentioning

confidence: 99%

The effects of combined antioxidant (β‐carotene, α‐tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single‐strand breaks and levels of insulin‐like growth factor‐1/IGF‐binding protein 3 in the ferret model of lung cancer

Kim

Lian

Yeum

et al. 2007

Intl Journal of Cancer

View full text Add to dashboard Cite

Insulin‐like growth factor 1 (IGF‐1) and its major binding protein, IGF binding protein 3 (IGFBP‐3) are implicated in lung cancer and other malignancies. We have previously shown that the combination of three major antioxidants [β‐carotene (BC), α‐tocopherol (AT) and ascorbic acid (AA)] can prevent lung carcinogenesis in a 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK)‐treated and smoke‐exposed (SM) ferret model, which is highly analogous to humans. The present study is aimed at determining the effect of the combination of BC, AT and AA on antioxidant capacity, lymphocyte DNA damage, plasma IGF‐1 and IGFBP‐3 concentrations, as well as on IGF‐1/IGFBP‐3 mRNA expression in the tissues (lung and liver) of the ferrets. Ferrets were treated with or without combined antioxidant (BC, AT and AA) supplementation (AOX) for 6 months in the following 4 groups: (i) control; (ii) SM+NNK; (iii) AOX; and (iv) SM+NNK+AOX. Combined AOX supplementation significantly attenuated SM+NNK induced lymphocyte DNA damage in the ferret, while increasing resistance to oxidative damage when challenged with H2O2 in vitro. Ferrets treated with SM+NNK had significantly lower IGFBP‐3 mRNA expression in lungs, whereas there was significantly higher IGFBP‐3 mRNA expression in the liver, as well as higher circulating IGFBP‐3 concentrations. Combined AOX supplementation did not affect the plasma or tissue (lung and liver) ratio of IGF‐1/IGFBP‐3. Combined antioxidant supplementation provides protection against smoke‐induced oxidative DNA damage, but does not affect the IGF‐1/IGFBP‐3 system. Differential expression of IGFBP‐3 in different tissues indicates that caution should be taken when using plasma IGFBP‐3 as a biomarker of tissue status. © 2007 Wiley‐Liss, Inc.

show abstract

The Effects of a Multivitamin/Mineral Supplement on Micronutrient Status, Antioxidant Capacity and Cytokine Production in Healthy Older Adults Consuming a Fortified Diet

Abstract: Supplementation with a multivitamin formulated at about 100% Daily Value can decrease the prevalence of suboptimal vitamin status in older adults and improve their micronutrient status to levels associated with reduced risk for several chronic diseases.

Cited by 66 publications

References 57 publications

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

Association of Dietary Supplement Use with Specific Micronutrient Intakes among Middle-Aged American Men and Women: The INTERMAP Study

The effects of combined antioxidant (β‐carotene, α‐tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single‐strand breaks and levels of insulin‐like growth factor‐1/IGF‐binding protein 3 in the ferret model of lung cancer

Contact Info

Product

Resources

About