Objective: To understand whether non-pharmacological treatment can reduce intensive care units. Methods: A review was conducted by searching the literature in the CINAHL, PubMed, PsycINFO, and EMBASE database. The prevalence of sputum in the ICU is 16%-89%. It is characterized by short-term memory loss, disorientation and impaired attention. There are three types of sputum, including hyperactivity, hyperactivity, and mixing. Both pharmacology and non-pharmacology include ABCDE care bundles, sedation, early mobilization, promotion of personal sleep quality, reduced noise and artificial lighting, and patient education. Music therapy as a non-pharmacological intervention has not been fully studied. CONCLUSIONS: Non-pharmacological treatment of sputum in the ICU remains an effective method because it eliminates the use of sedatives. However, this depends on the health of the patient, such as vision and hearing impairment. Exploring the effectiveness of music therapy for this condition will help to further improve the multi-component approach, which requires a combination of non-pharmacological interventions to promote patient health.