The effects of a 6-month resistance training and dried plum consumption intervention on strength, body composition, blood markers of bone turnover, and inflammation in breast cancer survivors

Simonavice, Emily; Liu, Pei-Yang; Ilich, Jasminka Z.; Kim, Jeong‐Su; Arjmandi, Bahram H.

doi:10.1139/apnm-2013-0281

Cited by 54 publications

(77 citation statements)

References 40 publications

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“…Similarly, Phillips et al (Phillips et al 2012) observed a 33 % reduction on CRP in obese postmenopausal women after 12 weeks of RT. Nevertheless, some authors have reported no effect of RT on CRP in older adults (Nikseresht et al 2014;Simonavice et al 2014). These conflicting results may be at least partly related to methodological issues between studies, such as training protocols that used different volumes and/or intensities, differences in characteristics of the participants (e.g., obese vs. non-obese), and differences in baseline CRP levels (Calle and Fernandez 2010;Donges et al 2013;Lera Orsatti et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience

Ribeiro

Tomeleri

Souza

et al. 2015

AGE

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The purpose of this study was to analyze the effects of a progressive resistance training (RT) program on C-reactive protein (CRP), blood glucose (GLU), and lipid profile in older women with differing levels of RT experience. Sixty-five older women (68.9 ± 6.1 years, 67.1 ± 13.1 kg) were separated according to RT experience: an advanced group composed by 35 participants who previously carried out 24 weeks of RT and a novice group composed by 30 participants without previous experience in RT (n = 30). Both groups performed a RT program comprised of eight exercises targeting all the major muscles. Training was carried out 3 days/week for 8 weeks. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), GLU, and CRP concentrations were determined pre-and post-intervention after 12 h fasting. A significant group by time interaction (P < 0.05) for the TC (novice = −1.9 % vs. advanced = 1.0 %), and CRP (novice = −22.9 % vs. advanced = −54.5 %) was observed. A main effect of time (P < 0.05) was identified for the GLU (novice = −2.6 % vs. advanced = −6.6 %), TG (novice = −12.9 % vs. advanced = −5.7 %), HDL-C (novice = +6.7 % vs. advanced = +2.6 %), and LDL-C (novice = −34.0 % vs. advanced = −25.4 %). These results suggest that RT improves the metabolic profile of older women and that training for a longer period of time seems to produce more pronounced reductions mainly on CRP.

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Section: Discussionmentioning

confidence: 99%

Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience

Ribeiro

Tomeleri

Souza

et al. 2015

AGE

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“…The literature search of the PubMed database yielded 50 articles [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]. After title/abstract review, 22 articles were screened in full-text and included in this comprehensive review [10,11,12,13,14,15,16,17,18,19,20,21,22,23,…”

Section: Resultsmentioning

confidence: 99%

“…After title/abstract review, 22 articles were screened in full-text and included in this comprehensive review [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,31,32]. Two additional studies [30,33] were included after examination of the reference lists of the 22 studies identified in the literature search.…”

Section: Resultsmentioning

confidence: 99%

“…All four clinical studies identified were derived from the same laboratory group [10,11,12,13,14], meriting the need for replication by additional investigators. Clinical studies included in this review had several limitations, such as a short duration of 3–12 months, which is a narrow window to see significant changes in BMD.…”

Section: Discussionmentioning

confidence: 99%

“…Participants in this study also received 500 mg of calcium and 400 IU of vitamin D during the intervention [10,13], even though administration of these supplements was equal across both arms. Simonavice et al, 2014 [14], assessed the effects of dried plums and resistance training vs. resistance training alone on blood markers of bone and inflammation in female breast cancer survivors. While this study found null effects, these results are likely not generalizable to healthy postmenopausal women experiencing normal hormone-related bone loss.…”

Section: Discussionmentioning

confidence: 99%

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Dried Plums, Prunes and Bone Health: A Comprehensive Review

Wallace

2017

Nutrients

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The 2015–2020 Dietary Guidelines for Americans advocate for increasing fruit intake and replacing energy-dense foods with those that are nutrient-dense. Nutrition across the lifespan is pivotal for the healthy development and maintenance of bone. The National Osteoporosis Foundation estimates that over half of Americans age 50+ have either osteoporosis or low bone mass. Dried plums, also commonly referred to as prunes, have a unique nutrient and dietary bioactive profile and are suggested to exert beneficial effects on bone. To further elucidate and summarize the potential mechanisms and effects of dried plums on bone health, a comprehensive review of the scientific literature was conducted. The PubMed database was searched through 24 January 2017 for all cell, animal, population and clinical studies that examined the effects of dried plums and/or extracts of the former on markers of bone health. Twenty-four studies were included in the review and summarized in table form. The beneficial effects of dried plums on bone health may be in part due to the variety of phenolics present in the fruit. Animal and cell studies suggest that dried plums and/or their extracts enhance bone formation and inhibit bone resorption through their actions on cell signaling pathways that influence osteoblast and osteoclast differentiation. These studies are consistent with clinical studies that show that dried plums may exert beneficial effects on bone mineral density (BMD). Long-term prospective cohort studies using fractures and BMD as primary endpoints are needed to confirm the effects of smaller clinical, animal and mechanistic studies. Clinical and prospective cohort studies in men are also needed, since they represent roughly 29% of fractures, and likewise, diverse race and ethnic groups. No adverse effects were noted among any of the studies included in this comprehensive review. While the data are not completely consistent, this review suggests that postmenopausal women may safely consume dried plums as part of their fruit intake recommendations given their potential to have protective effects on bone loss.

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What are the most effective exercise, physical activity and dietary interventions to improve body composition in women diagnosed with or at high‐risk of breast cancer? A systematic review and network meta‐analysis

Kudiarasu,

Lopez,

Galvão

et al. 2023

Cancer

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BackgroundObesity has been recognized as a risk factor in the development and recurrence of breast cancer and is also associated with poor prognostic outcomes. This systematic review and network meta‐analysis aimed to identify the most effective exercise, physical activity, and dietary interventions to reduce fat mass, body fat percentage and body weight as well as potentially increase lean mass in women diagnosed with or at high risk of breast cancer.MethodsA systematic search of databases was performed up to May 2022. Eligible randomized controlled trials examined the effects of exercise, physical activity and/or dietary interventions on fat mass and lean mass in women diagnosed with or at high risk of breast cancer. A random‐effects network meta‐analysis was conducted to determine the effects of different interventions across outcomes when sufficient studies were available.ResultsEighty‐four studies (n = 6428) were included in this review. Caloric restriction and combined exercise + caloric restriction significantly reduced fat mass (range, –3.9 to –3.7 kg) and body weight (range, –5.3 to –4.7 kg), whereas physical activity + caloric restriction significantly reduced body fat percentage (–2.4%; 95% confidence interval [CI], –3.4% to –13%) and body mass index (–2.2 kg × m–2; 95% CI, –3.0 to –1.4 kg × m–2) in breast cancer patients. Resistance exercise was the most effective intervention to increase lean mass (0.7 kg; 95% CI, 0.5–1.0 kg) in breast cancer patients.ConclusionMultimodal exercise and diet programs were the most effective interventions to reduce fat mass, body fat percentage, and body weight and increase and/or preserve lean mass.

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The effects of a 6-month resistance training and dried plum consumption intervention on strength, body composition, blood markers of bone turnover, and inflammation in breast cancer survivors

Cited by 54 publications

References 40 publications

Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience

Effect of resistance training on C-reactive protein, blood glucose and lipid profile in older women with differing levels of RT experience

Dried Plums, Prunes and Bone Health: A Comprehensive Review

What are the most effective exercise, physical activity and dietary interventions to improve body composition in women diagnosed with or at high‐risk of breast cancer? A systematic review and network meta‐analysis

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