The effects of 6-OHDA-induced dopamine depletions in the ventral or dorsal striatum on maternal and sexual behavior in the female rat

Hansen, Stefan; Harthon, Christina; Wallin, Elisabeth; Löfberg, Lena; Svensson, Kjell

doi:10.1016/0091-3057(91)90399-m

Cited by 150 publications

(111 citation statements)

References 40 publications

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“…Electrolytic (Galfori and Le Moal, 1979;Numan and Smith, 1984) or 6-hydroxydopamine (Hansen et al, 1991(Hansen et al, , 1993 lesions of the VTA or the n. Acc greatly disrupt maternal behavior. Infusion of the mixed D 1 -D 2 receptor antagonist flupenthixol into the n. Acc significantly reduces pup LG (Keer and Stern, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Dopamine-depleting 6-OHDA lesions of the n. Acc or the DA cell bodies in the VTA significantly disrupt maternal behavior (Hansen et al, 1991;Hansen, 1994). Infusions of D 1 and D 2 receptor antagonists into the n. Acc reduces pup retrieval and LG (Giordano et al, 1990;Hansen et al, 1991;Stern and Taylor, 1991;Keer and Stern, 1999). Interestingly, the n. Acc is broadly implicated in the processes of incentive motivation and mediates appetitive behaviors toward a wide range of "natural" reinforcers (Mitchell and Gratton, 1992;Robbins and Everitt, 1996;Ikemoto and Panksepp, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…In microdialysis studies, presentation of pups to a lactating dam increases extracellular DA levels (Hansen et al, 1993) and cFos expression in the nucleus accumbens (n. Acc; Fleming et al, 1994). Dopamine-depleting 6-OHDA lesions of the n. Acc or the DA cell bodies in the VTA significantly disrupt maternal behavior (Hansen et al, 1991;Hansen, 1994). Infusions of D 1 and D 2 receptor antagonists into the n. Acc reduces pup retrieval and LG (Giordano et al, 1990;Hansen et al, 1991;Stern and Taylor, 1991;Keer and Stern, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Champagne

Chretien²,

Stevenson³

et al. 2004

J. Neurosci.

328

257

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Champagne

Chretien²,

Stevenson³

et al. 2004

J. Neurosci.

328

257

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show abstract

“…However, ghrelin may also enhance non-homeostatic feeding by interacting with key reward systems Perello et al 2010;Skibicka et al 2011a;Skibicka et al 2011b). The reward system, specifically the mesolimbic dopamine system, mediates a state of well-being of natural and chemical reinforcers; it enhances motivation behaviours such as food-seeking and is involved in the development of addiction to drugs of abuse (Engel et al 1988;Hansen et al 1991;Schultz et al 1997). When consumed in excess and over time food can cause the same brain neuroadaptations as drug abuse (Grigson 2002).…”

Section: The Central Ghrelin Signalling Systemmentioning

confidence: 99%

The role of the central ghrelin system in reward from food and chemical drugs

Dickson

Egecioglu

Landgren

et al. 2011

Molecular and Cellular Endocrinology

217

168

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Here we review recent advances that identify a role for the central ghrelin signalling system in reward from both natural rewards (such as food) and artificial rewards (that include alcohol and drugs of abuse). Whereas ghrelin emerged as a stomach-derived hormone involved in energy balance, hunger and meal initiation via hypothalamic circuits, it now seems clear that it also has a role in motivated reward-driven behaviours via activation of the so-called "cholinergic-dopaminergic reward link". This reward link comprises a dopamine projection from the ventral tegmental area (VTA) to the nucleus accumbens together with a cholinergic input, arising primarily from the laterodorsal tegmental area. Ghrelin administration into the VTA or LDTg activates the "cholinergicdopaminergic" reward link, suggesting that ghrelin may increase the incentive value of motivated behaviours such as reward-seeking behaviour ("wanting" or "incentive motivation"). Further, direct injection of ghrelin into the brain ventricles or into the VTA

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“…result, primarily, from morphine-induced inhibition of GABAergic neurotransmission in the VTA, which disinhibits mesolimbic dopamine activity (Klitenick et al, 1992). Increases in mesolimbic dopamine activity seem to be involved in the neural mechanisms mediating multiple motivational phenomena, including maternal behavior (Byrnes et al, 2002;Hansen et al, 1991aHansen et al, , 1991bStern and Keer, 1999;Stolzenberg et al, 2007). Based on our previous work evaluating the effect of POEF on opioid-mediated hypoalgesia we speculate that POEF enhances the action of VTA morphine on maternal behavior by activating vagal afferent input to neural circuits that feed into mesolimbic neural circuitry (Ter Horst and Streefland, 1994, for review of vagal afferent distribution to the CNS), and specifically potentiating the effects of intra-VTA morphine by modulating δ-or κ-opioid-receptor activity, or both (DiPirro and Kristal, 2004).…”

mentioning

confidence: 99%

Ingestion of amniotic fluid enhances the facilitative effect of VTA morphine on the onset of maternal behavior in virgin rats

et al. 2009

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Previous research has shown that injection of morphine into the ventral tegmental area (VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal behavior in parturient rats. Placentophagia -ingestion of placenta and amniotic fluid, usually at parturition -modifies central opioid processes. Ingestion of the active substance in placenta and amniotic fluid, Placental Opioid-Enhancing Factor (POEF), enhances the hypoalgesic effect of centrally administered morphine, and more specifically, enhances δ-and κ-opioidreceptor-mediated hypoalgesia and attenuates μ-opioid-receptor-mediated hypoalgesia. POEF (in placenta or amniotic fluid) ingestion does not, by itself, produce hypoalgesia. In the present study, we tested the hypothesis that ingestion of amniotic fluid enhances the facilitative effect of opioid activity (unilateral morphine injection) in the VTA on the rate of onset of maternal behavior. Virgin female Long-Evans rats were given one intra-VTA injection of morphine sulfate (0.0, 0.01, or 0.03 μg, in saline) and an orogastric infusion of 0.25 ml amniotic fluid or saline once each day of the first three days of the 10-day testing period. Subjects were continuously exposed to foster pups that were replaced every 12 h; replacement of pups was followed by a 15-min observation period. Maternal behavior latency was determined by the first of two consecutive tests wherein the subject displayed pup retrieval, pup licking in the nest, and crouching over all foster pups, during the 15-min observation. We confirmed the previous finding that the VTA injection, alone, of 0.03 μg IntroductionRats at parturition show an almost immediate onset of appropriate maternal behavior. In contrast, the onset of maternal behavior in virgin rats that are continuously exposed to relatively constant-age foster pups (a procedure referred to as "concaveation", i.e., "with pups") is slow to appear, and is usually measured as the latency, in days, to the appearance of B R A I N R E S E A R C H 1 2 6 1 ( 2 0 0 9 ) 2 9 -3 6 ⁎ Corresponding author.

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The effects of 6-OHDA-induced dopamine depletions in the ventral or dorsal striatum on maternal and sexual behavior in the female rat

Cited by 150 publications

References 40 publications

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

The role of the central ghrelin system in reward from food and chemical drugs

Ingestion of amniotic fluid enhances the facilitative effect of VTA morphine on the onset of maternal behavior in virgin rats

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