The effects of 5-HTTLPR/rs25531 serotonin transporter gene polymorphisms on antisocial personality disorder among criminals in a sample of the Turkish population

Sah, Irmak; Yükseloğlu, Emel Hülya; Kocabaşoğlu, Neşe; Bayoğlu, Burcu; Cirakoglu, Emre; Cengiz, Müjgan

doi:10.1007/s11033-021-06137-y

Cited by 8 publications

(2 citation statements)

References 36 publications

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“…Previous studies have attributed about 50% of the variance in ASPD to genetic factors (Ferguson, 2010; Rautiainen et al, 2016; Rosenstrom et al, 2017). Research on genetic factors contributing to ASPD has mostly focused on monoamine‐like transmitter‐related genes such as tryptophan hydroxylase (TPH) (Nielsen et al, 1992), serotonin receptor (HTR) (Kling et al, 2008), serotonin transporter (5‐HTT/SLC6A4) (Douglas et al, 2011; Sah et al, 2021), monoamine oxidase A (MAOA) (Kolla, et al, 2017), dopamine D2 receptor (DRD2) (Ponce et al, 2009), androgen receptor (AR) (Raine, 2018), and catechol‐O‐methyltransferase (COMT) (Cuartas Arias et al, 2011). In turn, dopamine, serotonin, and norepinephrine are associated with three dimensions of personality traits: Novelty seeking, avoidance, and reward dependence, respectively (Cloninger, 1988).…”

Section: Introductionmentioning

confidence: 99%

The influence of NOS1AP gene polymorphisms and childhood abuse on antisocial personality disorder in Chinese male violent inmates

Ouyang

Liu

et al. 2022

Personality & Mental Health

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Antisocial personality disorder (ASPD) is a common behavioral pattern that causes sufferers to ignore or violate the rights of others. Though its cause is still unclear, previous studies have shown that childhood maltreatment is closely related to ASPD. The NOS1AP gene is associated with various neuropsychiatric diseases, but a linkage between it and ASPD has not yet been discovered. This study recruited ASPD and non‐ASPD male subjects who had committed violent crimes from a prison in Nanjing, China. By comparing the two groups' genotypes, allele frequencies, and histories of childhood abuse, we explored the interaction between the NOS1AP gene and childhood maltreatment on the pathogenesis of ASPD. The results showed that polymorphism rs945713 in the NOS1AP gene was associated with ASPD and furthermore that this SNP may be involved in regulating the effect of childhood abuse on ASPD. This study found that childhood trauma increases the risk of ASPD in violent adult male inmates; for prisoners with ASPD, it is critical to pay attention to their childhood trauma and take early psychological intervention.

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Section: Introductionmentioning

confidence: 99%

The influence of NOS1AP gene polymorphisms and childhood abuse on antisocial personality disorder in Chinese male violent inmates

Ouyang

Liu

et al. 2022

Personality & Mental Health

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“…This framework allows us to overcome the classic polarization of nature and nurture, to obtain an integrated perspective of human development [ 47 , 48 ]. Given the direct genetic involvement of SLC6A4 expressions in social development [ 49 ] and antisocial behavior [ 50 ], we assume that rs25531 could be indirectly associated with online social processes. In agreement with former outcomes [ 45 , 46 ], we also assume that the attachment status could moderate the effect of rs25531 on the Instagram behavior.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Instagram Number of Followings by Avoidance in Close Relationships in Young Adults under a Gene x Environment Perspective

Bonassi

Carollo

Cataldo

et al. 2021

IJERPH

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Social networking sites have determined radical changes in human life, demanding investigations on online socialization mechanisms. The knowledge acquired on in-person sociability could guide researchers to consider both environmental and genetic features as candidates of online socialization. Here, we explored the impact of the quality of adult attachment and the genetic properties of the Serotonin Transporter Gene (5-HTTLPR) on Instagram social behavior. Experiences in Close Relationships-Revised questionnaire was adopted to assess 57 Instagram users’ attachment pattern in close relationships with partners. Genotypes from the 5-HTTLPR/rs25531 region were extracted from the users’ buccal mucosa and analyzed. Users’ Instagram social behavior was examined from four indexes: number of posts, number of followed users (“followings”) and number of followers, and the Social Desirability Index calculated from the followers to followings ratio. Although no interaction between rs25531 and ECR-R dimensions was found, an association between avoidance in close relationships and Instagram number of followings emerged. Post hoc analyses revealed adult avoidance from the partner predicts the Instagram number of followings with good evidence. Moreover, users reporting high avoidance levels displayed fewer followings than users who reported low levels of avoidance. This research provides a window into the psychobiological understanding of online socialization on Instagram.

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Genetics and epigenetics of human aggression

Odintsova,

Hagenbeek,

van der Laan

et al. 2023

Brain and Crime

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The effects of 5-HTTLPR/rs25531 serotonin transporter gene polymorphisms on antisocial personality disorder among criminals in a sample of the Turkish population

Cited by 8 publications

References 36 publications

The influence of NOS1AP gene polymorphisms and childhood abuse on antisocial personality disorder in Chinese male violent inmates

The influence of NOS1AP gene polymorphisms and childhood abuse on antisocial personality disorder in Chinese male violent inmates

Modulation of Instagram Number of Followings by Avoidance in Close Relationships in Young Adults under a Gene x Environment Perspective

Genetics and epigenetics of human aggression

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