The Effects of 2 μG and 4 μG Doses of Dexmedetomidine in Combination with Intrathecal Hyperbaric Bupivacaine on Spinal Anesthesia and its Postoperative Analgesic Characteristics

Yektaş, Abdülkadir; Belli, Enver

doi:10.1155/2014/956825

Cited by 26 publications

(41 citation statements)

References 28 publications

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“…Dex produced a dose-dependent sedative effect between the groups (p < 0.001) in the present study which was supported by other studies [13,15,23]. On the other hand, Sudheesh et al [22] didn't find a significant difference between the groups; their result was supported by Kanzai et al [2] where their sedation score lies in the range of 0-1 for all patients.…”

Section: Discussionsupporting

confidence: 88%

“…Other adverse effects namely hypotension, nausea, and vomiting were comparable between the groups and went along with the results of other clinical studies [2,9,15,22]. On the other hand Yektas et al [23] noted clinically significant difference (p = 0.002) between the groups regarding hypotension.…”

Section: Discussionsupporting

confidence: 75%

“…Yektas et al [23] compared the effect of adding 2 mg and 4 mg dex to 15 mg of bupivacaine 0.5% on 60 male patients undergoing an inguinal hernia operation; they also found a statistically significant dose-dependent prolongation of sensory and motor block times between the groups (p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Intrathecal dexmedetomidine in TURP operations: A randomised controlled study

Taha

Shash

Goma

et al. 2017

Egyptian Journal of Anaesthesia

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 75%

See 1 more Smart Citation

Intrathecal dexmedetomidine in TURP operations: A randomised controlled study

Taha

Shash

Goma

et al. 2017

Egyptian Journal of Anaesthesia

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“…3,9,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Other control agents included fentanyl, [33][34][35][36] remifentanyl, 37,38 meperidine, 15 midazolam, [39][40][41] propofol, 43,44 ketamine, 45,46 tramadol, 24,47 clonidine, 42 propacetamol, 48 and buprenorphine 49 ( 8 were reported in the 39 included trials, and all studies reported every endpoint mentioned in the Methods section (reporting bias). 8 however, some bias 8 may exist in of the two trials, 27,32 as the length of surgery was not clear. An overview of the risk of bias is summarized in Fig.…”

Section: Study Characteristicmentioning

confidence: 99%

Efficacy of dexmedetomidine on postoperative shivering: a meta-analysis of clinical trials

Liu

Liang

et al. 2015

Can J Anesth/J Can Anesth

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Purpose Shivering is a frequent complication in the postoperative period. The aim of the current meta-analysis was to assess the efficacy of dexmedetomidine on postoperative shivering. with a minimum effective dose of 0.5 lgÁkg -1 (RR = 0.36; 95% CI: 0.21 to 0.60). The anti-shivering effect can be achieved both intravenously and epidurally when administered within two hours prior to the end of surgery. The efficacy of dexmedetomidine was similar to widely used anti-shivering agents, such as fentanyl, meperidine, tramadol, clonidine and so on; however, dexmedetomidine may increase the incidence of sedation, hypotension, bradycardia and dry mouth. Conclusions The present meta-analysis indicates that dexmedetomidine shows superiority over placebo, but not over other anti-shivering agents. Therefore, considering its high price and potential adverse events, dexmedetomidine may not be appropriate solely for the purpose of the prevention of postoperative shivering. RésuméObjectif Les frissons sont une complication fréquente en période postopératoire. L'objectif de cette méta-analyse était d'évaluer l'efficacité de la dexmédétomidine pour contrô ler les frissons postopératoires.

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“…Doses varying from 3 to 15 μg of DMT have been added as an adjuvant to intrathecal bupivacaine. [ 2 8 9 10 11 ] The present study tried to assess the effects of lower doses of DMT in ambulatory surgeries, hence doses of 3 and 5 μg were compared.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries: A prospective randomised controlled study

et al. 2015

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Background and Aims:Dexmedetomidine (DMT), as intrathecal adjuvant has been shown to successfully prolong duration of analgesia but delay the motor recovery. Hence, this study was designed to find out the dose of DMT which can provide satisfactory analgesia without prolonging motor block.Methods:A total of 50 patients scheduled for elective perianal surgeries were randomly allocated to Groups C or D (n = 25). Group D received hyperbaric bupivacaine 0.5% 4 mg + DMT 5 μg and Group C received hyperbaric bupivacaine 0.5% 4 mg + DMT 3 μg intrathecally. Onset and duration of sensory and motor blockade, duration of analgesia, time for ambulation and first urination were recorded. Adverse effects if any were noted.Results:Demographic characters, duration of surgery were comparable. The onset of sensory block to S1 was 9.61 ± 5.53 min in Group C compared to 7.69 ± 4.80 min in Group D (P = 0.35). Duration of sensory (145.28 ± 83.17 min – C, 167.85 ± 93.75 min – D, P = 0.5) and motor block (170.53 ± 73.44 min – C, 196.14 ± 84.28 min, P = 0.39) were comparable. Duration of analgesia (337.86 ± 105.11 min – C, 340.78 ± 101.81 min – D, P = 0.9) and time for ambulation (252.46 ± 93.72 min – C, 253.64 ± 88.04 min – D, P = 0.97) were also comparable. One patient in each group had urinary retention requiring catheterization. No other side effects were observed.Conclusion:Intrathecal DMT 3 μg dose does not produce faster ambulation compared to intrathecal DMT 5 μg though it produces comparable duration of analgesia for perianal surgeries.

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The Effects of 2 μG and 4 μG Doses of Dexmedetomidine in Combination with Intrathecal Hyperbaric Bupivacaine on Spinal Anesthesia and its Postoperative Analgesic Characteristics

Abstract: Two different doses of dexmedetomidine, an α2-adrenoceptor agonist with analgesic effects, resulted in an increased duration of analgesia and efficacy, decreased postoperative analgesic use and was associated with no notable adverse effects.

Cited by 26 publications

References 28 publications

Intrathecal dexmedetomidine in TURP operations: A randomised controlled study

Intrathecal dexmedetomidine in TURP operations: A randomised controlled study

Efficacy of dexmedetomidine on postoperative shivering: a meta-analysis of clinical trials

Comparative study of two doses of intrathecal dexmedetomidine as adjuvant with low dose hyperbaric bupivacaine in ambulatory perianal surgeries: A prospective randomised controlled study

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