The Effects of 1-Hydrazinophthalazine on Cerebral Blood Flow, Vascular Resistance, Oxygen Uptake and Jugular Oxygen Tension in Hypertensive Subjects 1

Hemodynamic Effects of 1-Hydrazinophthalazine in Patients With Arterial Hypertension 1

“…In spite of the increase in cardiac output, calculated left ventricular pressure work is not increased and the 02 consumption remains essentially the same. It seems clear that the vasodilatation produced by this drug is quite general since it is found in cerebral (15,16), hepatic (7,14), renal (11,17), and coronary vascular beds (18) as well as in the systemic and pulmonary vascular beds as a whole as shown in this study. However, the degree of vasodilatation is not the same in all areas (11,18).…”

“…Although pH determinations were not done in this study, arterial pH as determined by Hafkenschiel and his associates (15) showed a slight rise after administration of Hydralazine. The reason for this hyperventilation is not known, but the fact that it was less in the Group Two patients, who were most apprehensive and uncomfortable, suggests that it was not psychogenic.…”

“…The clinical diagnosis in each case was essential hypertension, although one patient (No. 15) had, in addition, old chronic pyelonephritis involving the lower half of the left kidney. None of these patients was in cardiac decompensation clinically or as measured by the central venous pressure at the time of study.…”

Cerebral Oxygen Consumption in Essential Hypertension Constancy with Age, Severity of the Disease, Sex, and Variations of Blood Constituents, As observed In 101 Patients1

“…Observations have now been made in 88 additional hypertensive patients distributed in several age groups (4)(5)(6)(7)(8)(9). The results in these 101 patients have been analyzed to determine whether cerebral oxygen metabolism varies with age, sex, degree of vascular damage elsewhere in the body (10,11), and with varying arterial and venous blood gas tension.…”

Hemodynamic Effects of 1-Hydrazinophthalazine (Apresoline) in Human Pregnancy: Results of Intravenous Administration 1

“…accompanied by an increase in renal plasma flow (11,12) and a decrease in cerebral vascular resistance (13). In man, inhibition or abolition of vasopressor reflexes by Apresoline, as well as inconsistent effects on the vasopressor action of epinephrine have been reported (2,14,15).…”