The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity

Cheng, Ziyun; Mei, Jianhui; Cao, Suqi; Zhang, Ran; Zhou, Jiawei; Wang, Yuwen

doi:10.3389/fnins.2021.624472

Cited by 2 publications

(5 citation statements)

References 54 publications

(60 reference statements)

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“…Our study even showed a tendency towards improved CS under mesopic conditions after administration of atropine, presumably due to the enlarged pupil 28 . Our results regarding contrast sensitivity under the influence of atropine are consistent with findings from earlier research: in a study that investigated the short-term and long-term effects of 0.01% atropine on CS, no significant reduction in CS was observed 18 .…”

Section: Discussionsupporting

confidence: 92%

“…Die vorliegenden Ergebnisse bez. der Kontrastempfindlichkeit unter Atropineinfluss decken sich mit früheren Erkenntnissen: In einer Studie, die die Kurzzeit-und Langzeiteffekte von 0,01 % Atropin auf KE untersucht hat, konnte keine signifikante Reduktion der KE festgestellt werden [18].…”

Section: Kontrastempfindlichkeit (Visual Function Analyzer)unclassified

“…Eine höhere Therapieeffizienz findet sich z. B. bei der Kombination von Orthokeratologielinsen mit einer täglichen Verabreichung von 0,01% Atropinaugentropfen 16 , 17 , 18 .…”

Section: Introductionunclassified

“…In the aim of improving or enhancing the therapeutic effect, the possibility of combining optical therapies with pharmacological intervention is under discussion. For example, increased therapeutic efficacy has been observed for the combination of orthokeratology lenses with daily administration of 0.01% atropine eye drops 16 , 17 , 18 .…”

Section: Introductionmentioning

confidence: 99%

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Sicherheit von Brillengläsern mit DIMS-Technologie und Atropin in der Kombinationstherapie der Myopieprogression

Kaymak

Mattern²,

Graff

et al. 2022

Klin Monbl Augenheilkd

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Hintergrund: Es soll die Sicherheit im Straßenverkehr beim Tragen von Brillengläsern mit Defocus Incorporated Multiple Segments (DIMS) Technologie in der Kombination mit Atropin evaluiert werden. Patienten und Methoden: An 12 jungen Erwachsenen (Alter: 24 bis 45; 30,1 ± 5,7 Jahre) wurde der Fernvisus und die Kontrastempfindlichkeit (KE), sowie Blendempfindlichkeit bei Versorgung mit DIMS-Brillengläsern allein und in der Kombination mit 0,01% Atropin untersucht. Ergebnisse: Durch Atropineinwirkung vermindert sich der Fernvisus beim Blick durch den zentralen Bereich des DIMS-Brillenglases nicht; bei Blendung und unter Atropin kommt es zu einem Visusabfall um 0,10 LogMAR. Beim erzwungenen Blick durch den DIMS-Bereich vermindert sich der Fernvisus durch Atropineinwirkung ohne Blendung um 0,09 LogMAR; bei Blendung ist durch Atropin kein weiterer Visusabfall zu beobachten. Die Kontrastempfindlichkeit mit DIMS-Gläsern wird durch Atropineinwirkung nicht relevant verändert. Hinsichtlich der Blendempfindlichkeit findet sich bei DIMS-Gläsern keine für das Sehen und die Sicherheit im Straßenverkehr relevante Sehbeeinträchtigung. Zusätzliche Atropinisierung hat keinen Einfluss auf die Blendempfindlichkeit. Schlussfolgerung: DIMS-Brillengläser sind sicher im Straßenverkehr und verursachen keine relevante Beeinträchtigung des Sehens, auch nicht unter Einfluss von 0,01 % Atropin. DIMS Brillengläser sind daher auch bei der Behandlung von progressiven Myopien in der Kombinationstherapie mit Atropin sicher. Background: The aim of this study was to evaluate traffic safety of Defocus Incorporated Multiple Segments (DIMS) spectacle lenses in combination therapy with atropine. Patients and Methods: 12 young adults (age: 24 -45; 30,1 ± 5,7 years) were recruited to evaluate corrected distance visual acuity (CDVA), contrast sensitivity (CS) (FrACT), glare sensitivity (Mesotest) under the influence of DIMS-spectacle correction alone and combination therapy with 0,01% atropine. Results: When looking through the central area of the DIMS lens, far vision does not decrease due to the influence of atropine; influence of glare and atropine leads to a reduction of CDVA by 0.10 LogMAR. When forced to look through the DIMS area, far vision is reduced by 0.09 LogMAR due to the influence of atropine in the absence of glare; in the presence of glare, no further loss of visual acuity can be observed under the influence of atropine. Contrast vision with DIMS glasses is not altered by the effects of atropine. Concerning glare sensitivity, DIMS lenses did not show any visual impairment that would be relevant to vision and road safety. Additional atropinization does not affect glare sensitivity. Conclusion: DIMS spectacle lenses are safe for participation in road traffic and do not relevantly impair traffic safety, neither alone nor under the acute influence of 0,01 % atropine.

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Section: Discussionsupporting

confidence: 92%

Section: Kontrastempfindlichkeit (Visual Function Analyzer)unclassified

“…Eine höhere Therapieeffizienz findet sich z. B. bei der Kombination von Orthokeratologielinsen mit einer täglichen Verabreichung von 0,01% Atropinaugentropfen 16 , 17 , 18 .…”

Section: Introductionunclassified

Section: Introductionmentioning

confidence: 99%

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Sicherheit von Brillengläsern mit DIMS-Technologie und Atropin in der Kombinationstherapie der Myopieprogression

Kaymak

Mattern²,

Graff

et al. 2022

Klin Monbl Augenheilkd

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“…This computerized device has been previously applied in studies concerning CSF after the use of atropine (Cheng et al, 2021). Contrast sensitivity was measured with sinusoidal gratings of spatial frequencies (1.5, 3, 6, 12, 18, and 24 cycles/degree) which were 3.0 × 3.0 at a viewing distance of 2 m. To minimize the edge effect, a 0.5° Gaussian ramp was added to blend the stimulus into the background.…”

Section: Visual Functionmentioning

confidence: 99%

The effect of orthokeratology lenses on optical quality and visual function in children

et al. 2023

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PurposeTo assess changes in optical quality and visual function in children after 3 months of wearing orthokeratology (OK) lenses.MethodsA total of 25 myopic children aged 8–12 years were recruited and completed the follow-up study. Optical quality, visual function and corneal morphology were assessed at baseline and at follow-ups 1 and 3 months after wearing OK lenses. Optical quality parameters mainly included the modulation transfer function (MTF) cutoff, objective scattering index (OSI), Strehl ratio (SR) and the predicted visual acuities (PVAs). Visual function was assessed by visual acuity, monocular contrast sensitivity function (CSF) across five spatial frequencies and the area under the log contrast sensitivity function (AULCSF) that was also computed as an index for overall CSF.ResultsThe MTF cutoff and SR values both increased after 1 month of wearing the OK lenses (baseline vs. 1 month: PMTF = 0.008 and PSR = 0.049); this improvement plateaued after 3 months of lens wear (1 month vs. 3 months: PMTF = 0.626, PSR = 0.428). The corneal morphology also showed the similar change trend. The OSI showed the opposite change trend (baseline vs. 1 month: POSI < 0.001; 1 month vs. 3 months: POSI = 0.720). The mean CSF at 1.5 cpd decreased significantly after 1 month of wearing the lenses (baseline vs. 1 month: p = 0.001) and recovered after 3 months of lens wear (baseline vs. 3 months: p = 0.076). CSF at spatial frequencies of 3, 6, 12 and 18 cpd as well as the AULCSF did not significantly differ between any two timepoints (all Ps > 0.05).ConclusionAfter 3 months of wearing OK lenses, the subjects exhibited a decrease in optical quality, similar to corneal morphology, whereas their visual function remained largely unchanged. Thus, the optical quality was more susceptible to OK lenses than visual function in children. The initial month of OK treatment of children is a key period to be paid close attention to deterioration of optical quality and visual function.

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The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity

Cited by 2 publications

References 54 publications

Sicherheit von Brillengläsern mit DIMS-Technologie und Atropin in der Kombinationstherapie der Myopieprogression

Sicherheit von Brillengläsern mit DIMS-Technologie und Atropin in der Kombinationstherapie der Myopieprogression

The effect of orthokeratology lenses on optical quality and visual function in children

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