The Effects Caused by Lavender and Rosemary for Salivary Cortisol, Stress Levels and Mood Alteration

Lee, Ae Ran; Cho, Hong Bum

doi:10.12940/jfb.2013.17.6.18

Cited by 7 publications

(2 citation statements)

References 8 publications

(4 reference statements)

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“…The regulation of serum cortisol concentration might be attributed to the presence in the formulation of Rosmarinus officinalis extract and Nigella sativa extract, as previous clinical investigations have demonstrated a decrease in this stress marker. 16,20 Emerging new evidence suggests that sleep may be strongly implicated in cardio-metabolic human health by regulating inflammatory pathways. Previous research has demonstrated a strong connection between sleep deprivation and increased inflammatory biomarkers such as tumour necrosis factor α (TNF-α), interleukin-6 (IL-6), and acute-phase reactant CRP.…”

Section: Variables and Groupsmentioning

confidence: 99%

A randomized, double-blind, parallel and placebo-controlled clinical study to evaluate the efficacy and safety of KaraCalm™: a dietary supplement to support sleep and manage stress

Gersappe,

Rajendran,

Layton

et al. 2024

Int J Basic Clin Pharmacol

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Background: KaraCalm™ is a novel polyherbal formulation obtained from the combination of Valeriana officinalis extract, Passiflora incarnata extract, Ocimum sanctum extract, Ziziphus jujuba extract, Rosmarinus officinalis extract, and Nigella sativa extract. The objective of the present investigation was to assess the efficacy and safety of KaraCalm™ to manage stress and improve sleep in healthy subjects in a randomized, double-blind, placebo-controlled clinical study. Methods: A total of 60 healthy volunteers were randomized into two groups, with 30 subjects in the KaraCalm™ group and 30 in the placebo group. Participants were asked to take KaraCalm™ 500 mg or placebo once daily for 56 days. As primary outcomes, sleep analysis was performed by using Actiwatch, while stress level was evaluated with the Perceived Stress Scale (PSS) scores from baseline to the end of the study period. Serum cortisol, and hs-CRP from baseline to the end of the study period were assessed as secondary endpoints. Results: An increase in overall sleep quality was observed in the KaraCalm™ group compared to the placebo as measured by total sleep time, onset latency, wake after sleep onset minutes, and number of awakenings. There was also a reduction in PSS scores in the KaraCalm™ group from baseline to the end of the study, indicating reduced stress levels. A significant reduction in Serum cortisol and hs-C-reactive protein (CRP) levels in the KaraCalm™ group from baseline to the end of the study further supported the effectiveness of KaraCalm™ in reducing stress. There was no significant change in the safety analyses of the patients in the intervention group when assessed from the start of the study to the end. Conclusions: KaraCalm™ can be considered a safe and effective dietary herbal Supplement to reduce stress and improve sleep quality.

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Section: Variables and Groupsmentioning

confidence: 99%

A randomized, double-blind, parallel and placebo-controlled clinical study to evaluate the efficacy and safety of KaraCalm™: a dietary supplement to support sleep and manage stress

Gersappe,

Rajendran,

Layton

et al. 2024

Int J Basic Clin Pharmacol

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show abstract

“… 36 Other studies examining the efficacy of lavender aromatherapy on stress levels found a measurable reduction in plasma and salivary cortisol levels in the aromatherapy groups. 37 , 38 , 39 A 2014 meta-analysis noted some supportive evidence of aromatherapy on perceived stress levels, but no statistical reduction on salivary cortisol levels. While this meta-analysis included studies with combined aromatherapy, lavender was the most common herb included.…”

Section: The Science and Safety Of Common Botanicals For Stressmentioning

confidence: 99%

Common herbs for stress: The science and strategy of a botanical medicine approach to self-care

Burns

2023

Journal of Interprofessional Education & Practice

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Aromatherapy: Therapy with Fragrances of Lavender Essential Oil

Milica,

Biljana

2023

Reference Series in Phytochemistry

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The Effects Caused by Lavender and Rosemary for Salivary Cortisol, Stress Levels and Mood Alteration

Cited by 7 publications

References 8 publications

A randomized, double-blind, parallel and placebo-controlled clinical study to evaluate the efficacy and safety of KaraCalm™: a dietary supplement to support sleep and manage stress

A randomized, double-blind, parallel and placebo-controlled clinical study to evaluate the efficacy and safety of KaraCalm™: a dietary supplement to support sleep and manage stress

Common herbs for stress: The science and strategy of a botanical medicine approach to self-care

Aromatherapy: Therapy with Fragrances of Lavender Essential Oil

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