The effectiveness of using nifuroxazide in acute intestinal infections of bacterial etiology in children

Gorelov, А.V.; Nikolaeva, S.V.; Usenko, D.V.; Плоскирева, А.А.; Руженцова, Т. А.; Mikhaylova, Ekaterina; Ситников, И. Г.; Tkhakushinova, N.Kh.; Dondurey, Elena A.; Краснова, Е. И.

doi:10.20953/1729-9225-2018-2-18-26

Cited by 3 publications

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“…Кроме того, желудочно-кишечные симптомы чаще наблюдали у детей младшего возраста, имеющих лихорадку и получающих антибактериальную терапию [7]. В то же время, согласно имевшимся ранее рекомендациям, при отсутствии подтверждения новой коронавирусной инфекции, наличии гемоколита, нейтрофилеза и других признаков бактериальной инфекции, при тяжелом течении, особенно, у детей первого года жизни, назначение антибиотиков считалось обоснованным [8,9,10]. У детей с гастроинтестинальными расстройствами отмечали более высокие уровни С-реактивного белка, прокальцитонина и, в целом, более тяжелое течение COVID-19 [7].…”

Section: актуальность проблемы особенности заболеваемости и клиническ...unclassified

Immunological aspects of COVID-19 in children

Volkov,

Ruzhentsova

2024

APPS

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The authors present a review of the literature on the peculiarities of immunity in children, which may explain the differences in the symptoms of COVID-19 in childhood. In children, COVID-19 tends to occur more easily than in adults. However, as in the years of the pandemic, and in the post-pandemic period, there were quite a few cases of complicated course with the need for hospitalization, and sometimes with fatal outcomes. Infants under the age of 1 year account for the highest percentage of hospitalizations among children. Currently, the analysis of the results of comparing the clinical manifestations of the disease and laboratory data is continuing. Basically, the features of COVID-19 in children are explained by the immaturity of the immune system and the atrial fibrillation of the respiratory tract. It is known that in childhood there are fewer angiotensin converting enzyme type 2 receptors (ACE 2, ACE 2), with which the coronavirus enters the human body. The disease caused by SARS-CoV-2 in children is often accompanied by gastrointestinal manifestations. A small percentage of sick children may develop an intense inflammatory reaction called “multisystem inflammatory syndrome”, also known as MIS-C. In this condition, high titers of antibodies to RBD SARS-CoV-2 and autoantibodies to free interleukin (IL) -1Ra are detected. These data should be taken into account when clarifying the prevention and treatment regimens aimed at preventing complications in the pediatric population.

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Section: актуальность проблемы особенности заболеваемости и клиническ...unclassified

Immunological aspects of COVID-19 in children

Volkov,

Ruzhentsova

2024

APPS

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“…Тяжелое течение отмечается у 3-4% пациентов, когда к симптомам выраженной интоксикации могут присоединиться явления менингизма или судорожный синдром, сопровождающиеся комплексом признаков нарушений функции сердечно-сосудистой системы, печени, поджелудочной железы и почек [4,19]. Осложнения кампилобактериоза можно разделить на две группы: ранние и поздние [20]. Наибольшее внимание в настоящий момент в работах как зарубежных, так и отечественных авторов уделяется поздним осложнениям кампилобактериоза.…”

Section: клинический случайunclassified

Liver Damage in Campylobacteriosis in Children (Clinical Case)

Ермоленко,

Алагова,

Раздьяконова

2023

Клиническая Инфектология И Паразитология

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В настоящее время кампилобактериоз является одной из наиболее значимых причин бактериальных кишечных инфекций и диарей путешественников в мире. Своевременная диагностика кампилобактериоза и его осложнений является актуальной проблемой и предметом научных исследований. Формирование гепатита при кампилобактериозе, по разным данным, может иметь место у 3–19% детей с кампилобактериозом, выявляется на 1–3-й неделе заболевания и проявляется умеренным повышением уровня сывороточных трансаминаз в 2–3 раза, имеет благоприятное течение. В данной статье описывается клинический случай кампилобактериоза у ребенка 3 лет, осложненного реактивным гепатитом, госпитализированного в ДНКЦИБ. В статье использованы клинико-эпидемиологические, лабораторные данные и сведения из медицинской документации. Опираясь на данные исследований других авторов, рассматриваются наиболее вероятные механизмы поражения печени при кампилобактериозе. На основании данных о высокой распространенности кампилобактериоза и наличия большого количества наблюдений, подтверждающих риски развития острого гепатита при кампилобактериозе, следует отметить необходимость сохранения настороженности у врачей на предмет развития кампилобактерного поражения печени, а также включения маркеров функции печени в обязательный протокол обследования у детей с подтвержденным кампилобактериозом. Currently, campylobacteriosis is one of the most significant causes of bacterial infections and diarrhea in the world. Timely diagnosis of campylobacteriosis and its results are a pressing problem and serve as the basis for scientific research. The formation of hepatitis in campylobacteriosis, according to various sources, can occur in 3 to 19% of children with campylobacteriosis, manifests itself at 1–3 weeks of the disease and reveals a moderate increase in the level of serum transaminases by 2–3 times, which is favorable for the course. This article describes a clinical case of campylobacteriosis in a 3-year-old child, complicated by reactive hepatitis, hospitalized at the DNA Clinical Hospital. The article uses clinical, epidemiological, laboratory data and information from medical documentation. Based on these studies, other authors conclude about the most likely mechanisms of liver damage in campylobacteriosis. Based on data on the high prevalence of campylobacteriosis and the indication of a large number of observations confirming the risks of developing acute hepatitis with campylobacteriosis, it should be noted the need to maintain alertness among doctors regarding the development of campylobacteriosis of the liver, as well as the inclusion of markers of liver function in the mandatory observation protocol for children with campylobacteriosis.

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Nifuroxazide Pharmaceutical Preparations in the Russian Federation. Publication One: Nomenclature, Chemical and Pharmaceutical Characteristics of the Preparations’ Composition

Kocherovets

Mardanly

2021

A&Ch

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One of the most used antimicrobial nitrofurans in Russian medical practice is nifuroxazide, which is distinguished by high therapeutic eﬃcacy, drug safety, as well as economic availability in the treatment of acute bacterial diarrhea without deterioration of the general condition, fever, and intoxication. In the Russian Federation (RF), nifuroxazide preparations in general circulation are supplied by 19 domestic and foreign pharmaceutical organizations. The aim of this study was to analyze the nomenclature, as well as chemical and pharmaceutical characteristics of excipients (EXs) in the composition of nifuroxazide preparations, which received state registration in the RF. A comparative study of the chemical and pharmaceutical characteristics of EXs of 42 nifuroxazide preparations in the form of capsules, tablets, and suspension for oral administration was carried out. The pharmaco-economic status is noted and the demand prospects for all forms of nifuroxazide preparations in the RF are outlined. Quantitative and qualitative diﬀerences in the composition of the EXs of a number of nifuroxazide preparations in the form of capsules and suspensions has been shown.

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The effectiveness of using nifuroxazide in acute intestinal infections of bacterial etiology in children

Cited by 3 publications

References 0 publications

Immunological aspects of COVID-19 in children

Immunological aspects of COVID-19 in children

Liver Damage in Campylobacteriosis in Children (Clinical Case)

Nifuroxazide Pharmaceutical Preparations in the Russian Federation. Publication One: Nomenclature, Chemical and Pharmaceutical Characteristics of the Preparations’ Composition

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