The Effectiveness of Trigeminal Nerve Stimulation on Traumatic Brain Injury

Yang, Qian; Zhang, Subo; Xu, Zhizhan; Liu, Lijiaqi; Fan, Shengnuo; Wu, Shaoling; Ma, Chao

doi:10.1016/j.neurom.2021.10.014

Cited by 7 publications

(12 citation statements)

References 42 publications

(43 reference statements)

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“…This widespread nature of the effect suggests that gamma stimulation facilitates communication and integration of information across the entire cortex. This notion is supported by a recent study reporting that trigeminal nerve stimulator activates widespread brain areas in mouse models with traumatic brain injury 44 …”

Section: Discussionmentioning

confidence: 56%

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Acoustic‐electric trigeminal‐nerve stimulation enhances functional connectivity in patients with disorders of consciousness

Wu,

Concolato,

Sorger

et al. 2023

CNS Neurosci Ther

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AimDisruption of functional brain connectivity is thought to underlie disorders of consciousness (DOC) and recovery of impaired connectivity is suggested as an indicator of consciousness restoration. We recently found that rhythmic acoustic‐electric trigeminal‐nerve stimulation (i.e., musical stimulation synchronized to electrical stimulation of the trigeminal nerve) in the gamma band can improve consciousness in patients with DOC. Here, we investigated whether these beneficial stimulation effects are mediated by alterations in functional connectivity.MethodsSixty‐three patients with DOC underwent 5 days of gamma, beta, or sham acoustic‐electric trigeminal‐nerve stimulation. Resting‐state electroencephalography was measured before and after the stimulation and functional connectivity was assessed using phase‐lag index (PLI).ResultsWe found that gamma stimulation induces an increase in gamma‐band PLI. Further characterization revealed that the enhancing effect is (i) specific to the gamma band (as we observed no comparable change in beta‐band PLI and no effect of beta‐band acoustic‐electric stimulation or sham stimulation), (ii) widely spread across the cortex, and (iii) accompanied by improvements in patients' auditory abilities.ConclusionThese findings show that gamma acoustic‐electric trigeminal‐nerve stimulation can improve resting‐state functional connectivity in the gamma band, which in turn may be linked to auditory abilities and/or consciousness restoration in DOC patients.

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Section: Discussionmentioning

confidence: 56%

“…This notion is supported by a recent study reporting that trigeminal nerve stimulator activates widespread brain areas in mouse models with traumatic brain injury. 44 …”

Section: Discussionmentioning

confidence: 99%

Acoustic‐electric trigeminal‐nerve stimulation enhances functional connectivity in patients with disorders of consciousness

Wu,

Concolato,

Sorger

et al. 2023

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…TRPV1 and the transient receptor potential ankyrin subtype 1 channel can be involved in neurogenic inflammatory responses following TBI through Aδ and C-fibers ( Corrigan et al, 2016 ; da Silva Fiorin et al, 2020 ; X.-J. Yang et al, 2022 ). A subset of Aδ nociceptors can also be directly activated or sensitized by irritant chemical stimuli such as protons, prostaglandins, or bradykinin ( Lang et al, 1990 ; Martin et al, 1987 ; Steen et al, 1992 ).…”

Section: Pathophysiology Of Pth and Associated Mechanisms After Tbimentioning

confidence: 99%

“…For example, bilateral trigeminal nerve stimulation (TNS) (the infraorbital branch of the maxillary nerve (V2); a current intensity of 0.1 mA; pulse width of 200 μs; frequency of 10 Hz for 30 s/min) for 60 min one day after TBI in mice markedly reduced neuroinflammation by TNF-α and IL-6 (Q. Yang et al, 2022 ). Pro-inflammatory mediators were concomitantly downregulated in the caspase-3 signaling pathway, while brain edema was reduced, and the blood-brain barrier was protected (Q.…”

Section: Pathophysiology Of Pth and Associated Mechanisms After Tbimentioning

confidence: 99%

Inflammation, brain connectivity, and neuromodulation in post-traumatic headache

da Silva Fiorin,

do Espírito Santo,

Da Silva

et al. 2024

Brain, Behavior, & Immunity - Health

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“…It has been observed that TNS of rats with impaired consciousness can upregulate neuropeptide hypocretin in the lateral hypothalamus and this activation can promote consciousness recovery 15 . In other animal models with traumatic brain injury, TNS has been demonstrated to enhance cerebral blood flow, protect the blood-brain barrier, and reduce brain edema 16, 17 . Similar effects of TNS have been shown in human patients diagnosed with disorders of consciousness (DOC).…”

Section: Introductionmentioning

confidence: 99%

Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perception

Auksztulewicz

Riecke

2023

Preprint

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Multimodal stimulation can reverse pathological neural activity and improve symptoms in neuropsychiatric diseases. For example, recent research shows that multimodal acoustic-electric trigeminal-nerve stimulation (TNS) (i.e., musical stimulation synchronized to transcutaneous electrical stimulation of the trigeminal nerve) can improve consciousness in patients with disorders of consciousness. However, the reliability and mechanism of this novel approach remain largely unknown. In the present study, we explored the effects of multimodal acoustic-electric TNS in healthy human participants using a double-blinded, randomized, crossover design. We assessed conscious perception before and after stimulation using behavioral and neural measures in tactile and auditory target-detection tasks. To explore the mechanisms underlying the putative effects of acoustic-electric stimulation, we fitted a biologically plausible neural network model to the neural data using dynamic causal modeling. We observed that (1) acoustic-electric stimulation can improve conscious tactile perception in healthy human participants without a concomitant change in auditory perception, (2) this improvement is caused by the interplay of the acoustic and electric stimulation rather than any of the unimodal stimulation alone, and (3) the effect of acoustic-electric stimulation on conscious perception correlates with inter-regional connection changes in a recurrent neural processing model. These results provide evidence that acoustic-electric trigeminal-nerve stimulation can promote conscious perception, and therewith corroborate the usefulness of multimodal stimulation. Alterations in inter-regional cortical connections might be the mechanism by which acoustic-electric TNS achieves its consciousness benefits.

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The Effectiveness of Trigeminal Nerve Stimulation on Traumatic Brain Injury

Cited by 7 publications

References 42 publications

Acoustic‐electric trigeminal‐nerve stimulation enhances functional connectivity in patients with disorders of consciousness

Acoustic‐electric trigeminal‐nerve stimulation enhances functional connectivity in patients with disorders of consciousness

Inflammation, brain connectivity, and neuromodulation in post-traumatic headache

Multimodal acoustic-electric trigeminal nerve stimulation modulates conscious perception

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