Introduction: Firefighters are set to respond to a number of dynamic demands within their roles that extend well beyond fire suppression. These tasks (i.e., heavy lifting, awkward postures) and their unpredictable nature are likely con tributing factors to musculoskeletal disorders (MSDs). Several individual studies have assessed the prevalence of MSDs among Canadian fi refi ghters. Therefore, a systematic review and meta-analysis was conducted to critically appraise the quality of the body of available literature and to provide pooled point-and period-prevalence estimates of anatomical regions of MSDs among Canadian fi refi ghters. Methods: The MEDLINE, Embase, PubMed and Web of Science data bases were searched from inception to November 2018. Cross-sectional cohort studies with musculoskeletal prevalence estimates (point-and period-) of career/professional fi refighters in Canada were identified and critically appraised. MSDs were defined as sprains/strains, fractures/dislocations and self-reported bodily pain (chronic or acute). Periodand point-prevalence estimates were calculated, and study-specific estimates were pooled using a random-eff ects model. Results: Five eligible cohort studies (3 prospective, 2 retrospective) were included, with a total of 4,143 fi refi ghters. The participants had a mean age range of 34 (SD = 8.5) to 42.6 (SD = 9.7) years. The reported types of MSDs in cluded sprain or strain, fractures, head, neck, shoulder, elbow, arm, hand, back, upper thigh, knee, and foot pain. Th e point-prevalence estimate of shoulder pain was 23.00% (3 studies, 312 of 1,491 fi refighters, 95% CI, 15.00-33.00), back pain was 27.0% (3 studies, 367 of 1,491 fi refighters, 95% CI, 18.00-38.00), and knee pain was 27.00% (2 studies, 180 of 684 fi refighters, 95% CI, 11.00-48.00). The one-year period-prevalence estimate of all sprain/strain injuries (all body parts) was 10.0% (2 studies, 278 of 2,652 fi refighters, 95% CI, 7.00-14.00). Discussion: High point-prevalence estimates (1 in 4 fi refighters) of shoulder-, back-, and knee-related MSDs were identified among Canadian fi refi ghters. This emphasizes the need for early assessment, intervention, and injury prevention strategies that reflect how units work together to maximize ergonomic efficiency and injury prevention.