The Effectiveness of Snail Slime and Chitosan in Wound Healing

Biomolecules from snail mucus (Helix aspersa) conjugated gold nanoparticles, exhibiting potential wound healing and anti-inflammatory activity

“…Indeed, the SS protein content plays a key role in cell regeneration and growth, preventing the effect of inflammatory disease. 21,22 The SS main compounds are used as reducing agents enabling AuNP synthesis via the reduction of Au(III), from a HAuCl 4 solution, to Au(0), while forming an organic layer around the AuNPs. AuNPs-SS are thus synthesized by using a single step reaction, avoiding the use of additional and toxic agents.…”

“…For example, Conte et al 23 reported that the pharmacokinetics of snail components does not permit their optimal absorption, so the combined use of AuNPs, well-known antibacterial agents, and SS could be a functional ingredient in the treatment of acne and in biotechnology, or used as a preservative in cosmetic product formulation. Considering the overall published literature, 21,22,[24][25][26][27] although interesting information can be found on the SS use, the presence of fragmentary and not detailed investigations suggests that this research field has not been extensively explored yet. In a time when cosmetic dermatology and beauty care are increasingly influential, 28,29 we intend to discuss the biogenic formation of AuNPs-SS by characterizing them and by using as accelerating wound healing and anti-inflammatory agents in biomedicine.…”

Chitosan/snail slime films as multifunctional platforms for potential biomedical and cosmetic applications: physical and chemical characterization

“…And there are even fewer if we refer to the synergistic activity of chitosan and SS. 16,44,45 Thus, this work aims to widen the SS applicability and, for this purpose, a comprehensive investigation of the physical and chemical properties of a CH/SS hybrid film is performed. In particular, a suitable formulation for preparing CH/SS films was presented, and, among the large number of features that these composites exhibit, attention was focused on their ability to act as antioxidants and UV protectors, boosting the basic chitosan activity.…”

Injectable Chitosan–Methoxy Polyethylene Glycol Hybrid Hydrogel Untangling the Wound Healing Behavior: In Vitro and In Vivo Evaluation

“…19 Chitosan, a natural biopolymer, plays a significant role in wound healing due to its outstanding bioadhesive, hemostatic, anti-inflammatory, antimicrobial, and tissue regeneration properties. 20 Administration of chitosan in hydrogels is also of great interest nowadays because of its self-healing characteristics. 21 Based on previous expertise, we have introduced methoxy polyethylene glycol (mPEG) as the second important component of injectable optimized hybrid hydrogel together with chitosan for animal wound healing.…”

“…Compared to synthetic polymers, natural polymers are preferred for hydrogels because of their low toxicity, excellent biocompatibility, ease of degradation, rich source, and low cost. , Chitosan, a natural amino polysaccharide, contains various reactive functional groups, including amine and hydroxyl, which form hydrogels through chemical cross-linking. , It is also reported that chitosan can perform many therapeutic actions like anti-inflammatory, antibacterial, hemostatic, wound healing, and antioxidant activities . Chitosan, a natural biopolymer, plays a significant role in wound healing due to its outstanding bioadhesive, hemostatic, anti-inflammatory, antimicrobial, and tissue regeneration properties . Administration of chitosan in hydrogels is also of great interest nowadays because of its self-healing characteristics …”