The effectiveness of simethicone in improving visibility during colonoscopy when given with a sodium phosphate solution: A double-blind randomized study

Sudduth, Robert H.; DeAngelis, Sofia A.; Sherman, Kenneth E.; McNally, Peter R.

doi:10.1016/s0016-5107(95)70041-2

Cited by 64 publications

(42 citation statements)

References 4 publications

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“…Five areas of the colon (rectosigmoid, descending, transverse, ascending, and cecum) were graded for the amount of air bubbles. The amount of intraluminal air bubbles was classified into four grades as shown below [24] : Grade 0 = No or minimal scattered bubbles; Grade 1 = Bubbles covering at least half the luminal diameter; Grade 2 = Bubbles covering the circumference of the lumen; Grade 3 = Bubbles filling the entire lumen.…”

Section: Protocolmentioning

confidence: 99%

“…The re-defined grading was classified by following the more practical report by Sudduth et al [24] . The most frequent grading was selected to represent the overall grading; for example, if the grade was 0, 0, 0, 1, 1 the patient was assigned an overall grade of 0.…”

Section: Protocolmentioning

confidence: 99%

“…The presence of air bubbles along the colonic surface can prevent the clear visualization of the whole colon. Simethicone works as an adjunct to bowel preparation with the purpose of diminishing foam for mation and improving visualization during colonoscopy [23][24][25][26][27][28] . However, most of the previous studies that demonstrated enhanced quality of bowel preparation used PEG for the bowel preparation regimen [23][24][25][26][27][28] .…”

Section: Introductionmentioning

confidence: 99%

“…Simethicone works as an adjunct to bowel preparation with the purpose of diminishing foam for mation and improving visualization during colonoscopy [23][24][25][26][27][28] . However, most of the previous studies that demonstrated enhanced quality of bowel preparation used PEG for the bowel preparation regimen [23][24][25][26][27][28] . Furthermore, only liquid simethicone was used as an adjunct therapy in these studies [23][24][25][26][27][28] .…”

Section: Introductionmentioning

confidence: 99%

“…The benefit of simethicone in improving colonic bowel preparation, however, was not explored in previous studies [23][24][25][26][27][28] . Moreover, other factors such as time of colonoscopy, endoscopist, and patient satisfaction have never been mentioned [23][24][25][26][27][28] . Although some endoscopists already use simethicone prior to performing colonoscopic examination in daily practice, the adjunctive use of simethicone in the standard bowel preparation regimen has not been uniformly accepted so far.…”

Section: Introductionmentioning

confidence: 99%

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Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation

Tongprasert

Sobhonslidsuk²,

Rattanasiri³

2009

WJG

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AIM:To evaluate the effectiveness of simethicone in enhancing visibility and efficacy during colonoscopy. METHODS:A prospective, double-blind, randomized, placebo-controlled study was conducted. One hundred and twenty-four patients were allocated to receive 2 doses of sodium phosphate plus 240 mg of tablet simethicone or placebo as bowel preparation. Visibility was blindly assessed for the amount of air bubbles and adequacy of colon preparation. Total colonoscopic time, side effects of the medication, endoscopist and patient satisfaction were also compared. RESULTS:Sodium phosphate plus simethicone, compared to sodium phosphate plus placebo, improved visibility by diminishing air bubbles (100.00% vs 42.37%, P < 0.0001) but simethicone failed to demonstrate improvement in adequacy of colon preparation (90.16% vs 81.36%, P = 0.17). Endoscopist and patient satisfaction were increased significantly in the simethicone group. However, there was no difference in the total duration of colonoscopy and side effects of the medication. CONCLUSION:The addition of simethicone is of benefit for colonoscopic bowel preparation by diminishing air bubbles, which results in enhanced visibility. Endoscopist and patient satisfaction is also increased.

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Section: Protocolmentioning

confidence: 99%

Section: Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation

Tongprasert

Sobhonslidsuk²,

Rattanasiri³

2009

WJG

View full text Add to dashboard Cite

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Comparison of three types of preparations for abdominal sonography

Barbosa

Chojniak

Cohen

et al. 2011

J of Clinical Ultrasound

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Oral simethicone tablets with PEG‐ELS split‐prep reduces frequency of inadequate bowel cleansing and decreases bubbles

et al. 2021

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Background: Intraluminal bubbles may prevent the visualisation of mucosa during a colonoscopy. Simethicone minimises bubbles, but its impact on incomplete bowel preparation and optimal protocols for use are unclear. Aim:To assess the impact of oral simethicone tablets when added to 2-litre, splitprep, polyethylene glycol electrolyte lavage solution + ascorbic acid on bubble score and frequency of incomplete bowel preparation.Methods: This QA/QI project assessed outpatients who underwent colonoscopy at the Veterans Affairs Ann Arbor Healthcare System. After endoscopists were trained in intraluminal bubble scoring systems, data about bubble score, frequency of inadequate bowel preparation requiring early repeat colonoscopy, quality of bowel preparation using Boston Bowel Preparation Scale (BBPS), and patient tolerance were collected before and after addition of oral simethicone 160mg to each dose of 2-litre split-prep.Results: There were no differences in patient characteristics between the baseline group (n = 348) and the simethicone group (n = 354). Simethicone improved the total mean intraluminal bubble score from 8.18 to 8.78 (P < 0.001). Early repeat colonoscopy due to inadequate bowel preparation was higher in the baseline group vs simethicone group: 8.7% vs 4.6%, P = 0.03 with an RRR = 0.5 (95% CI 0.26-0.95).Using BBPS, the frequency of having inadequate cleansing in any colon segment was higher in the baseline group vs simethicone group: 6.6% vs 3.1%; RRR = 0.55 (95% CI 0.21-0.94). | 255 MARATT eT Al. How to cite this article: Maratt JK, Freeman AE, Schoenfeld P, et al. Oral simethicone tablets with PEG-ELS split-prep reduces frequency of inadequate bowel cleansing and decreases

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The effectiveness of simethicone in improving visibility during colonoscopy when given with a sodium phosphate solution: A double-blind randomized study

Cited by 64 publications

References 4 publications

Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation

Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation

Comparison of three types of preparations for abdominal sonography

Oral simethicone tablets with PEG‐ELS split‐prep reduces frequency of inadequate bowel cleansing and decreases bubbles

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