The Effectiveness of Prophylactic Etodolac on Postendodontic Pain

Abstract

To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy. Patient-reported visual analog scale ratings of pain intensity were conducted upon initial clinical presentation, immediately postoperative, 4, 8, 12, 24, 48, and 72 h after initiation of root canal therapy. Results showed that prophylactic ibuprofen administration significantly reduced postendodontic pain at 4 and 8 h after initiation of root canal therapy, when compared with etodolac and a placebo. Patients with a periapical diagnosis of acute apical periodontitis or with a Phoenix abscess showed a significant increased need for additional medication after completion of root canal therapy, compared with all other periapical diagnoses.

Efficacy of Ibuprofen and Ibuprofen/Acetaminophen on Postoperative Pain in Symptomatic Patients with a Pulpal Diagnosis of Necrosis

“…Menke et al (19) studied patients with varying pulpal and periapical diagnoses. They compared 400 mg etodolac and 600 mg ibuprofen with a placebo in 36 patients postoperatively and at 4, 8, 12, 24, 48, and 72 hours.…”

“…Some studies have evaluated the occurrence of interappointment emergencies (7,8,10,(14)(15)(16), intracanal medicament pain (11,13,21,22), use of analgesics (17)(18)(19)(20)23), and effect of drainage on postoperative pain (4). Unfortunately, many of these studies have not separated the diagnosis of pulpal conditions (vital versus necrotic) and have only evaluated postoperative pain during short time intervals.…”

“…Unfortunately, many of these studies have not separated the diagnosis of pulpal conditions (vital versus necrotic) and have only evaluated postoperative pain during short time intervals. Menhinick et al (12), Menke et al (19), and Mickel et al (23) have stressed the need for more studies of postoperative pain in endodontics that address medication use specific to the pulpal diagnosis and preoperative level of patients' pain.…”

An Analysis of Current Analgesic Preferences for Endodontic Pain Management

“…(Continued)20. How many times a day do you recommend your patients take a narcotic pain medication for postoperative pain control?…”

Clinical Trial of Combination of Acetaminophen, Ibuprofen and Caffeine on Pain Relief and Analgesic Use After Impacted Lower Third Molar Surgery

“…According to our findings, comparing the 2 groups showed a significant effect on reducing the pain at 2, 4, and 8 hours after surgery based on VAS pain score. In a similar study, ibuprofen management significantly reduced pain at 4 and 8 hours after surgery (20). Moreover, Wells et al (2011) compared the use of ibuprofen against ibuprofen/acetaminophen to reduce pain in a randomized double-blind study and found a decrease in pain levels and analgesic use over time for both groups (21,22).…”