The effectiveness of neoadjuvant chemotherapy in the treatment of cervical cancer (clinical case)

Abstract

For the treatment of stage 2 cervical cancer, surgical treatment, chemoradiotherapy or neoadjuvant chemotherapy in combination with paclitaxel and carboplatin followed by extended uterine extirpation of type III can be used. The positive effects of a combination of neoadjuvant chemotherapy with surgery are shown. A clinical case of treatment of a 43-year-old patient with a diagnosis of: cervical cancer IB2 stage T2a2N0M0. At the first stage of treatment, the patient was prescribed 3 courses of neoadjuvant chemotherapy in a combination of paclitaxel and carboplatin. There was a decrease in the size of the cervical tumor by 25 % on the RECIST scale. At the second stage of treatment, extended uterine extirpation was performed with the removal of the upper third of the vagina, fallopian tubes, parotid tissue and regional lymph nodes with ovarian transposition. The patient’s prognosis is favorable, and further dynamic monitoring is recommended. The presented clinical case demonstrates the possibility of using neoadjuvant chemotherapy in combination with paclitaxel and carboplatin and subsequent extended extirpation of the uterus type III with ovarian transposition in the treatment of stage IIA2 cervical cancer in a woman of reproductive age. After the first stage of treatment 3 courses of neoadjuvant chemotherapy, patient S. had a decrease in the size of the cervical tumor by 25 % on the RECIST scale according to pelvic MRI data, which later allowed to proceed to the second stage surgical intervention. Taking into account the known prognostic factors, the patient has a favorable prognosis for life and requires further dynamic monitoring.