The effectiveness of local action of nano oxides on wound infection

Abstract

The treatment of wound-related combat injuries and antibiotic resistance require the search for new approaches to reduce the risk of infectious complications, this will increase the effectiveness of therapy and even save lives. The aim of our study was to establish the mechanism of action and effectiveness of nano oxides applied to wound infection. The antimicrobial activity of different concentrations of solutions of zinc (nZnO), magnesium (nMgO) and silicon (nSiO2) nano oxides was studied by agar diffusion against clinical antibiotic-sensitive strains of opportunistic Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), isolated from patients with purulent-septic diseases. It was found that nZnO exhibits extremely high antibacterial activity against S. aureus, E. сoli. The ultra-low content of nZnO (1.56 mg/ml) completely destroys S. aureus, unlike nMgO, the effective concentration of which exceeds the minimum by 16 times. It is known that nZnO has the highest antimicrobial properties against S. aureus and E. coli, this effectiveness is achieved due to the features of the structure and the possibility of the formation of oxygen and a number of other radicals. These qualities of nZnO make it possible to integrate it into dressings for wound treatment.