The Effectiveness of Injectable Hyaluronic Acid in the Improvement of the Facial Skin Quality: A Systematic Review

Abstract

Background: Several studies have evaluated the role of various injectable formulations of hyaluronic acid (HA) in the improvement of the quality of facial skin. It is important to systematically summarize the available evidence in this regard. Methods: Relevant databases were searched for clinical studies that evaluated the therapeutic role of any injectable formulation of HA in improving the quality of facial skin in adult humans until 31 December 2022. The available studies were critically analyzed and the data were extracted. Results: A total of 2996 articles were screened and 13 studies were finally included. Eight studies evaluated the effect of various formulations of HA alone, while five evaluated the effect of various formulations of HA along with other active ingredients (cocktails) on the quality of facial skin. All types of HA formulations cause a significant improvement in facial skin quality, in terms of hydration, firmness, skin-tiring effect/fatigue, brightness, texture, radiance, and elasticity. The effect of HA monotherapy was more pronounced than that of the cocktail ingredients. HA treatment was quite safe and the patient satisfaction level was high. Conclusion:The clinical evidence on the use of injectable HA alone in the improvement of the quality of facial skin, in terms of hydration, firmness, skin-tiring effect/fatigue, brightness, texture, radiance, and elasticity, is quite promising. Large randomized controlled trials are required in this regard.

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Report

“…Moreover, when small (0.3 to 0.8 mm) adipose tissue clusters are injected, cellular blood irroration is improved, along with the degree of engraftment [ 30 ]. Coleman [ 55 ] emphasized that when placing fat, it is imperative to maximize the surface area contact with the surrounding tissue to ensure the proximity of the grafted fat to the recipient’s vasculature.…”

“…The periocular area is the only area where the authors suggest injecting tissue in the submuscular plane [ 30 , 37 , 38 ] ( Figure 10 and Figure 11 ). In this area, the skin is very thin, and the subcutaneous tissue is minimally represented.…”

“…Combined guided SEFFI and hyaluronic acid (HA) treatments are performed to enhance the volume of the face in a particular area, such as the malar, zygomatic, and jawline areas [ 30 ]. In such cases, the HA injection is performed before the more profound guided SEFFI.…”

“…Since 2015 [ 17 , 28 , 29 , 30 , 31 , 32 , 33 ], several studies have been published that prove that by using a special cannula with tiny side portholes, the adipose tissue can be harvested so as to select small cellular clusters that do not require any manipulation to reduce the clusters’ dimensions and fluidify the tissue.…”

Emerging Evidence for the Effectiveness of Profhilo® Figura Body Cream in Enhancing Skin Hydration, Elasticity, and Firmness

“…In general, severe skin laxity and roughness cases can be treated using surgical intervention [3].On the other hand, mild to moderate cases can be improved using energy-based devices, such as lasers, radiofrequency, or ultrasonic devices [3].However, energy-based devices can be expensive, require repeat procedures, can cause pain and burns, and its use is associated with restrictions, such as no sunlight exposure between treatments [3]. Alternatively, hyaluronic acid-based injectable treatments have also been shown to be effective as hyaluronic acid can maintain hydration (by binding to and retaining water), turgidity, viscosity, and plasticity of the connective tissue [3][4][5][6][7]. Other benefits of hyaluronic acid include its bio-stimulatory or nutricosmetic effect, which can promote collagen formation, and its low allergenic potential [3,8].…”