The effectiveness of flaxseed (Linum usitatissimum L.) on the inflammatory response in patients with familial hypercholesterolemia receiving lipid apheresis‐preliminary results

Abstract

Familial hypercholesterolemia is associated with severe abnormalities including atherosclerosis, dyslipidemia, cardiovascular disease, oxidative stress, inflammation, and endothelium dysfunction. Flaxseed in the diet acts upon blood lipids, lowering cholesterol, and also has anti‐oxidative effects. These effects are beneficial for patients suffering from atherosclerosis, dyslipidemia and endothelium dysfunction.The protocol consists of four stages: a run‐in phase of 10 weeks (patients on a standard diet) and an experimental stage ‐ flaxseed supplementation or placebo (whole‐wheat) supplementation, and wash out phase of 10 weeks. Samples of saliva and blood were collected after each phase of the trial, just before routine lipoprotein apheresis, which is usually once every two weeks. Saliva myeloperoxidase levels were analyzed by ELISA test, and flow cytometry was used for measurement of circulating microparticles. The study adhered to the Principles of the Declaration of Helsinki.The concentration of salivary myeloperoxidase was lower after flaxseed supplementation.The number of circulating microparticles: CD105 (endothelial‐derived), CD45 and CD41 (platelet‐derived)) was smaller after flaxseed supplementation compared with a run in phaseConclusionsOur preliminary observations indicate that a diet containing flaxseed may improve endothelial cell function and thus contribute to the amelioration of unfavorable effects associated with hypercholesterolemia.Support or Funding InformationThere is no actual or potential conflict of interest in this presentation. The Nutricia Research Foundation Poland provided the research grant support.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.