The effectiveness of exercise interventions to increase physical activity in Cystic Fibrosis: A systematic review

Curran, Máire; Tierney, Audrey C.; Button, Brenda; Collins, Louise; Kennedy, Lauren; McDonnell, Ciara; Casserly, Brian; Cahalan, Róisín

doi:10.1016/j.jcf.2021.10.008

Cited by 4 publications

(5 citation statements)

References 46 publications

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“…The interventions implemented were home exercise training programs, and controlling the signs and symptoms and treatment adherence. Physical activity and exercise have numerous benefits in patients with CF, including improved FEV 1 , aerobic capacity, lung function, exercise capacity, and quality of life [37]. These patients show some difficulties in exercise, symptom management, and therapeutic adherence that are essential for controlling the disease, preventing exacerbations, and slowing progression [37,38].…”

Section: Discussionmentioning

confidence: 99%

“…Physical activity and exercise have numerous benefits in patients with CF, including improved FEV 1 , aerobic capacity, lung function, exercise capacity, and quality of life [37]. These patients show some difficulties in exercise, symptom management, and therapeutic adherence that are essential for controlling the disease, preventing exacerbations, and slowing progression [37,38]. Non-compliance with the therapeutic regimen has multiple clinical and economic consequences, with increased mortality or morbidity observed in non-compliant patients [38].…”

Section: Discussionmentioning

confidence: 99%

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Telerehabilitation in Children and Adolescents with Cystic Fibrosis: A Scoping Review

Pessoa,

Ferreira,

Baixinho

2024

Healthcare

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Cystic fibrosis requires regular monitoring and intervention by healthcare teams; despite that, adherence to therapeutic measures is less than desired. The evolution of technology has allowed much of the care provided in person to be replaced by a telehealth delivery model, but studies on telerehabilitation are scarce and dispersed. This scoping review aimed to identify which domains of rehabilitation intervention are mediated by information and communication technologies and how they are developed in the provision of care to children and adolescents with cystic fibrosis. The data collection was conducted in February and June 2023, following the three steps recommended by the JBI for this type of review: (1) the search was conducted in MEDLINE, CINAHL, Scopus, JBI, and Web of Science; (2) the bibliographic references obtained from the included articles were analysed; and (3) the grey literature was checked. The eligibility criteria were children and adolescents and rehabilitation interventions mediated by information and communication technologies. The five studies included in this review were subjected to analysis, and a narrative synthesis of the results was carried out. The interventions identified included physical exercise programs (60%), management of the therapeutic regimen (40%), and symptom control (40%). The information and communication technologies were web-based platforms, video games, and telephones. The use of telerehabilitation included face-to-face meetings to ensure participants performed the exercises correctly, monitor their response to exercise, and teach them how to avoid risky situations during home workouts. In all studies, exercise sessions were supervised by the participants’ parents or caregivers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Telerehabilitation in Children and Adolescents with Cystic Fibrosis: A Scoping Review

Pessoa,

Ferreira,

Baixinho

2024

Healthcare

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“…The end of a periodized and intense programme in the short-term may be synonymous with fatigue, or even lassitude, and this criterion should rather be assessed in the medium- or long-term. A recent systematic review including children and adult pwCF reported an increase in PA levels in 11 out of 15 studies following an exercise training programme including activity counselling [ 43 ]. In addition, two studies in our analysis showed that the benefits gained during training tended to be lost as early as 4 weeks after the end of the programme, without a strategy for maintaining the gains [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise Training on Peripheral Muscle Strength in Children and Adolescents with Cystic Fibrosis: A Meta-Analysis

et al. 2022

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Background: Exercise training is a cornerstone of care for people with cystic fibrosis (pwCF); it improves exercise capacity and health-related physical fitness, but no meta-analysis has investigated its effects on muscle function in young pwCF. The objective of this meta-analysis was to assess the effects of exercise on peripheral muscle strength in young pwCF. Methods: An electronic search was conducted in four databases (Pubmed, Science Direct, CENTRAL, and PEDRO) from their inception to July 2022. Grey literature databases (OpenGrey, the European Respiratory Society, the American Thoracic Society, and the European Cystic Fibrosis Society) were also consulted. Randomized controlled trials comparing any type of exercise with standard care in young pwCF (5 to 19 years old) were included. Two authors independently selected the relevant studies, extracted the data, assessed the risk of bias (using the Rob2 tool), and rated the quality of the evidence. Results: Ten studies met the inclusion criteria, involving 359 pwCF. Exercise training improved both lower and upper limb muscle strength (SMD 1.67 (95%CI 0.80 to 2.53), I2 = 76%, p < 0.001 and SMD 1.30 (95%CI 0.66 to 1.93), I2 = 62%, p < 0.001, respectively). Improvements were also reported in muscle mass and maximal oxygen consumption. Results regarding physical activity levels were inconclusive. The overall risk of bias for the primary outcome was high. Conclusions: Exercise training may have a positive effect on peripheral muscle strength in young pwCF. The evidence quality is very low and the level of certainty is poor. There is a need for high-quality randomized controlled studies to confirm these results.

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“…However, in a recent systematic review investigating if exercise interventions improved overall physical levels in pwCF, only 6 of 15 included studies reported a significant increase in physical activity postintervention. 24 A recent large multinational trial recruiting pwCF aged 12 years and older found that a partially supervised exercise program over 12 months significantly increased physical activity levels. 25 However, this study failed to achieve its recruitment target and physical activity was a secondary outcome measure, limiting the strength of this finding.…”

Section: Exercise In Cystic Fibrosismentioning

confidence: 99%

“…13 31 Several literature reviews have suggested that activity counseling, combined with regular monitoring or review over the medium term (i.e., months and not weeks) may have the highest likelihood of increasing physical activity levels in pwCF. 24 31 A recent study, aiming to recruit pwCF who were relatively inactive (≤4 hours of vigorous physical activity per week) to a partially supervised exercise program, failed to achieve its recruitment target, despite recruiting for nearly 4 years, highlighting the challenges in this area. 25 Since the coronavirus disease 2019 pandemic, there has been a rapid increase in telehealth availability and this may serve as a useful adjunct to improve adherence and clinical outcomes for pwCF.…”

Section: Exercise In Cystic Fibrosismentioning

confidence: 99%

Exercise and Airway Clearance Techniques in Cystic Fibrosis

Ward

Stiller

Holland

2022

Semin Respir Crit Care Med

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Exercise and airway clearance techniques (ACTs) have been a cornerstone of treatment for people with cystic fibrosis (pwCF) for many decades. Exercise may confer both respiratory and nonrespiratory benefits for pwCF, with greater exercise capacity associated with improved survival. A wide variety of exercise interventions for pwCF have been investigated. ACTs may assist in reducing respiratory symptoms for pwCF and are currently recommended to be performed daily, with the types of ACTs used varying globally. While recommended components of care, both exercise and ACTs are time-intensive and maintaining adherence to the recommendations over the longer term can be challenging. It has been proposed that with advances in the therapeutic options for pwCF, a rationalization of the therapeutic regimen may be possible. We summarize the current evidence for the use of exercise and ACTs by pwCF, discuss the implications of the introduction of cystic fibrosis transmembrane conductance regulator modulators on both exercise and ACTs, and highlight areas for further research.

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The effectiveness of exercise interventions to increase physical activity in Cystic Fibrosis: A systematic review

Cited by 4 publications

References 46 publications

Telerehabilitation in Children and Adolescents with Cystic Fibrosis: A Scoping Review

Telerehabilitation in Children and Adolescents with Cystic Fibrosis: A Scoping Review

Effects of Exercise Training on Peripheral Muscle Strength in Children and Adolescents with Cystic Fibrosis: A Meta-Analysis

Exercise and Airway Clearance Techniques in Cystic Fibrosis

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