The Effectiveness of Begonia Multangula Blume Leaf Ethanol Extract as Polymicrobial Antibiofilm on Catheters

Jabbar, Asriullah; Hamzah, Hasyrul; Nandini, Erika; Nurwijayanto, Ari; Setyowati, Endang; Syakri, Syamsuri; Rija&rsquo;i, Hifdzur; Mubarak, Mubarak

doi:10.21608/ejchem.2022.118622.5341

Cited by 3 publications

(1 citation statement)

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“…Over the recent years, natural products and their structural analogues have played a significant part in drug discovery [35,36] especially in the area of infectious disease due to their safety and efficacy [37,38]. Citrus peel flavonoids are great pharmacotherapy candidates [39][40][41] especially as antibacterial agents as shown by previous research [42,43].…”

Section: Introductionmentioning

confidence: 96%

In-vitro and In-silico Evaluation of Citrus Peel Flavonoids as Potential Antibacterial Agents against Streptococcus pneumoniae Isolated from Pneumonia Patients

Sabbagh

Awwad²,

Alwassouf³

2023

Egypt. J. Chem.

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Streptococcus pneumoniae is a leading cause of bacterial pneumonia. The continuing global threat of antimicrobial resistance alongside pneumonia being one of the largest infectious diseases worldwide raises the urgent need of novel alternatives to antibiotics using molecular docking, and Citrus flavonoids are well-known antibacterial agents. Purpose: In-silico and in-vitro evaluation of the antibacterial activity of 29 flavonoid found Citrus peels to identify their activity against S. pneumoniae isolated from pneumonia patients and a reference strain. Methods: Conventional methods had been used to identify Streptococcus pneumoniae and determine its sensitivity to antibiotics. Well diffusion and microdilution methods were employed for the in-vitro evaluation. The in-silico study was done using two docking programs as modern approaches to identify activity to Toxin-Antitoxin complex (HicBA) as a possible target in S. pneumoniae. Results: Binding affinity using iGEMDOCK was lower for glycosidic flavonoids than their respective aglycones. Binding affinity using AutoDock Vina for Quercetin (-6.7 kcal/mole), Rutin (-7.1 kcal/mole) compared to Vancomycin (-6.4 kcal/mole), minimum inhibitory concentration (MIC) range of the of 62.5-500 µg/ml compared to Rutin (-78->500 µg/ml). Conclusions: The docking study implied that HicBA may be a potential target for Citrus flavonoids. Rutin had milder effects on S. pneumoniae denoting that sugar moiety's role is limited. Quercetin may be a possible antibacterial agent for S. pneumoniae.

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Section: Introductionmentioning

confidence: 96%

In-vitro and In-silico Evaluation of Citrus Peel Flavonoids as Potential Antibacterial Agents against Streptococcus pneumoniae Isolated from Pneumonia Patients

Sabbagh

Awwad²,

Alwassouf³

2023

Egypt. J. Chem.

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Antihyperurisemia Activity of Etanol Extract of Etlingera rubroloba A.D Poulsen Fruits on Uric Acid and Cyclooxygenase-2 Levels In Vivo

Jabbar,

Halik,

Malik

et al. 2024

RJPT

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Etlingera rubroloba A.D Poulsen (E. rubroloba) plants from the genus Etlingera, empirically used as traditional medicine by several ethnicities in Southeast Sulawesi, namely to increase endurance and relieve joint pain. The purpose of this study was to determine the antihyperuricemia activity on uric acid levels and cyclooxygenase-2 (COX-2) levels in vivo in mice. This study used six groups of test animals consisting of normal, negative (Na-CMC) 0.5%, positive control (allopurinol) and dose groups of ethanol extract of E. rubroloba fruit 100, 200 and 300 mg/g bw. Modeling of hyperuricemia test animals is done by inducing potassium oxonate. Measurement of uric acid levels by lateral chromatography method and COX-2 levels by ELISA method. The results showed that ethanol extract of E. rubroloba fruit can reduce uric acid and COX-2 levels (p<0.05). The results of the correlation statistical test showed a positive correlation between uric acid levels and COX-2 levels, where the decrease in uric acid levels was directly proportional to the decrease in COX-2 levels. This research can be a reference in the development of traditional medicine, especially anti-hyperuricemia.

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Acute Toxicity Test of Zebrafish, Antifungal and Antibiofilm Activity of Etlingera rubroloba A.D Poulsen against Candida albicans

Jabbar,

Ilyas Y,

Hamzah

et al. 2024

RJPT

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The Etlingera rubroloba A.D Poulsen (E.rubroloba) plant is empirically used as a joint pain reliever, wound and fungus medicine by the people of Southeast Sulawesi. This plant has never been reported regarding toxicity and biofilm against C. albicans, but other activities have been reported previously. This study aims to determine the acute toxicity of ethanol extract of Etlingera rubroloba using zebrafish, antifungal and antibiofilm activity against C.albicans, using 5 concentration of 625, 1250, 2500, 5000 and 10000µg/mL.The results of the acute toxicity test ethanol extracts of stems, fruits and rhizomes, respectively to LC50 3898.23, 10310.52 and 4065.10µg/mL based on probit analysis. The highest inhibitory values in antifungal (10,000µg/mL) were stem, fruit, rhizome and nystatin at 80.28; 81.98; 81.53 and 80.99%, respectively. In the antibiofilm test, the highest inhibition value at 24 hours MBIC was in the stem, fruit, rhizome and nystatin as a positive control, respectively 77.83; 77.66; 78.42 and 78.62%. Then at 48 hours MBIC were 74.9, 74.63, 73.80 and 74.82%, respectively. The conclusion of this study is that the stem and rhizome category is slightly toxic and the fruit is practically non-toxic, and has activity as an antibiofilm of C. albicans.

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The Effectiveness of Begonia Multangula Blume Leaf Ethanol Extract as Polymicrobial Antibiofilm on Catheters

Cited by 3 publications

References 0 publications

In-vitro and In-silico Evaluation of Citrus Peel Flavonoids as Potential Antibacterial Agents against Streptococcus pneumoniae Isolated from Pneumonia Patients

In-vitro and In-silico Evaluation of Citrus Peel Flavonoids as Potential Antibacterial Agents against Streptococcus pneumoniae Isolated from Pneumonia Patients

Antihyperurisemia Activity of Etanol Extract of Etlingera rubroloba A.D Poulsen Fruits on Uric Acid and Cyclooxygenase-2 Levels In Vivo

Acute Toxicity Test of Zebrafish, Antifungal and Antibiofilm Activity of Etlingera rubroloba A.D Poulsen against Candida albicans

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