The Effectiveness of an App (Insulia) in Recommending Basal Insulin Doses for French Patients With Type 2 Diabetes Mellitus: Longitudinal Observational Study

Abstract

Background For patients with type 2 diabetes (T2D), calculating the daily dose of basal insulin may be challenging. Insulia is a digital remote monitoring solution that uses clinical algorithms to recommend basal insulin doses. A predecessor device was evaluated in the TeleDiab-2 randomized controlled trial, showing that a higher percentage of patients using the app achieved their target fasting blood glucose (FBG) level compared to the control group, and insulin doses were adjusted to higher levels without hypoglycemia. Objective This study aims to analyze how the glycemic control of Insulia users has evolved when using the app in a real-life setting in France. Methods A retrospective observational analysis of data collected through the device in adult French patients with T2D treated with basal insulin and oral antihyperglycemic agents using the system for ≥6 months was conducted. Analyses were descriptive and distinguished the results in a subpopulation of regular and compliant users of the app. Glycemic outcomes were estimated considering the percentage of patients who achieved their individualized FBG target between 5.5 and 6 months following the initiation of device use, the frequency of hypoglycemia resulting in a treatment change over the 6-month period of exposure, and the evolution of the average hemoglobin A1c (HbA1c) level over the same period. Results Of the 484 users, 373 (77.1%) performed at least one dose calculation. A total of 221 (59.2%) users were men. When app use started, the mean age, BMI, HbA1c, and basal insulin dose were 55.8 (SD 11.9) years, 30.6 (SD 5.9) kg/m2, 10.1% (SD 2.0%), and 25.5 (SD 15.8) IU/day, respectively. Over a median use duration of 5.0 (95% CI 3.8-5.7) months, patients used the system 5.8 (SD 1.6) times per week on average, and 73.4% of their injected doses were consistent with the app’s suggested doses. Among regular and compliant user patients (n=91, ≥5 measurements/week and ≥80% adherence to calculated doses), 60% (55/91) achieved the FBG target (±5%) at 6 months (5.5-6 months) versus 51.5% (145/282) of the other patients (P=.15). There was an increase in the proportion of patients achieving their target FBG for regular and compliant users (+1.86% every 2 weeks) without clear improvement in other patients. A logistic model did not identify the variables that were significantly associated with this outcome among regular and compliant users. In the overall population, the incidence of reported hypoglycemia decreased simultaneously (–0.16%/month). Among 82 patients, the mean HbA1c decreased from 9.9% to 7.2% at 6 months. Conclusions An improvement in glycemic control as measured by the percentage of patients reaching their FBG individualized target range without increasing hypoglycemic risk was observed in patients using the Insulia app, especially among regular users following the dose recommendations of the algorithm.

Exploring the Antidiabetic Potential of Neocarya macrophylla (Nm) Leaf Fractions: A Comprehensive Study on Hypoglycemic Activity, Body Mass Index, and Hematological Parameters in High-Fat Diet/ Streptozotocin-Induced Diabetic Rat

“…By analyzing the percentage reduction in blood glucose levels at specific time points using different fractions, it is possible to evaluate the effectiveness of various fractions in managing glycemic control. This method allows for a detailed understanding of how effective are different fractions, thereby aiding in the identification of the most effective fraction and the optimal dose needed to control blood glucose (27,28). Monitoring percentage glycemic variability provides valuable insights into the impact of different doses on glycemic control, helping healthcare providers tailor treatment regimens to achieve optimal blood glucose management and reduce the risk of diabetes-related complications (27,29).…”

“…For example, a study on Smilax glabra demonstrated its hypoglycemic activity in type 2 diabetic mouse models, highlighting its ability to reduce blood glucose levels and improve insulin sensitivity (32). Similarly, Tectona grandis leaves have shown antidiabetic properties through modulation of glucose absorption and uptake, leading to reduced hyperglycemia in diabetic rats (33). Other plants like Costus speciosus, Coccinia grandis, and several African medicinal plants have been identified for their oral hypoglycemic properties and potential to manage diabetes (34)(35)(36).…”

Efficacy of a basal insulin dose management smartphone application for controlling fasting blood glucose in patients with type‐2 diabetes mellitus: A single‐centre, randomised clinical study

“…After its launch in France, only half of the patients were regular users in the first 3 months, and that number was reduced to 24.4% of patients after 6 months. 13 The cumbersome operation of the application may affect the user's willingness to use it in the long term. The DIABEO system faces the same problem of low usage if access to the app is in the hands of the patient, and clinicians cannot guarantee that the app will be used regularly.…”

“…Insulia is a smartphone app that provides BI dose recommendations. After its launch in France, only half of the patients were regular users in the first 3 months, and that number was reduced to 24.4% of patients after 6 months 13 . The cumbersome operation of the application may affect the user's willingness to use it in the long term.…”