The effectiveness of adjunct mindfulness-based intervention in treatment of bipolar disorder: A systematic review and meta-analysis

Chu, Che‐Sheng; Stubbs, Brendon; Chen, Tien‐Yu; Tang, Chia-Hung; Li, Dian‐Jeng; Yang, Wei‐Cheng; Wu, Ching-Kuan; Carvalho, André F.; Vieta, Eduard; Miklowitz, David J.; Tseng, Ping‐Tao; Lin, Pao‐Yen

doi:10.1016/j.jad.2017.08.025

Cited by 64 publications

(47 citation statements)

References 55 publications

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“…Enhancements in cognitive functions and emotional regulation, including frequency of manic episodes, were observed in patients diagnosed with bipolar disorder (BD) following regular mindfulness meditation practice. Despite the limited number of studies, MBCT seems to represent a promising treatment in BD in conjunction with pharmacotherapy . Promising but still embryonal results were found for symptom control in those with psychotic disorders …”

Section: Focus On Mental Health and Stress Management: Clinical Effecmentioning

confidence: 99%

Stress and the psyche–brain–immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review

Bottaccioli

Minelli

2018

Annals of the New York Academy of Sciences

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In the last decades, psychoneuroendocrineimmunology research has made relevant contributions to the fields of neuroscience, psychobiology, epigenetics, molecular biology, and clinical research by studying the effect of stress on human health and highlighting the close interrelations between psyche, brain, and bodily systems. It is now well recognized that chronic stress can alter the physiological cross-talk between brain and biological systems, leading to long-lasting maladaptive effects (allostatic overload) on the nervous, immune, endocrine, and metabolic systems, which compromises stress resiliency and health. Stressful conditions in early life have been associated with profound alterations in cortical and subcortical brain regions involved in emotion regulation and the salience network, showing relevant overlap with different psychiatric conditions. This paper provides a summary of the available literature concerning the notable effects of stress on the brain and immune system. We highlight the role of epigenetics as a mechanistic pathway mediating the influences of the social and physical environment on brain structure and connectivity, the immune system, and psycho-physical health in psychiatric diseases. We also summarize the evidence regarding the effects of stress management techniques (mainly psychotherapy and meditation practice) on clinical outcomes, brain neurocircuitry, and immune-inflammatory network in major psychiatric diseases.

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Section: Focus On Mental Health and Stress Management: Clinical Effecmentioning

confidence: 99%

Stress and the psyche–brain–immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review

Bottaccioli

Minelli

2018

Annals of the New York Academy of Sciences

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“…Yet, in spite of this, mindfulness-based treatments added to psychotherapy and the usual antidepressants 2 have been confi rmed for years now as a promising intervention adjuvant to the therapeutic approach to depression, thus improving the residual depressive symptoms after a depressive episode or preventing relapses and recurring depression in clinical populations [17,18). The potentially benefi ci al effects of mindfulness on bipolar patients suffering from anxiety and depressive disorders have recently been confi rmed [19]. The utility of mindfuln ess on severe and persistent mental disorders is also likely [19,20], since it has already been suggested that mindfulness could improve the quality of life of patients suffering from these types of disorders [21].…”

Section: Full Awareness or Mindfulness Adjuvant In The Treatment Of mentioning

confidence: 99%

“…The potentially benefi ci al effects of mindfulness on bipolar patients suffering from anxiety and depressive disorders have recently been confi rmed [19]. The utility of mindfuln ess on severe and persistent mental disorders is also likely [19,20], since it has already been suggested that mindfulness could improve the quality of life of patients suffering from these types of disorders [21]. Brief, appropriate training in mindfulness has shown positive effects in the reduction of symptoms like sadness, mental rumination, Pali -pāli, an Indic language, similar to Sanskrit used in the ancient Indo-Aryan periodis, according to theravāda tradition, the language from Magadha (an ancient kingdom in Northeast India and present-day Nepal), where Buddhism emerged.…”

Section: Full Awareness or Mindfulness Adjuvant In The Treatment Of mentioning

confidence: 99%

Full awareness or mindfulness in the practice of current clinical psychology and psychiatry: Explanatory contributions

Jm¹

2019

Ann Psychiatry Treatm

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Introduction: In accordance with relevant historical sources and the objective of reducing the conceptual ambiguity surrounding full awareness or mindfulness, it should be emphasized that the aim of these concepts is better self-regulation and that the task of the observer is to remain equanimous between attraction and repulsion of what is being observed. Methods: A search for the word or descriptor "mindfulness" with the use of modern search engines and research databases with thesaurus, such as Medline-PubMed, PsycINFO, Embase, the Cochrane Library and InDICEs-CSIC, results in such a high number of records that this is, in practice, unmanageable. Therefore, this article, which is essentially a theoretical review and an opinion study, will only take into consideration the most important, novel or signifi cant fi ndings. Results: Full awareness is adjuvant to the treatment of certain mental disorders. It is known that meditation training can improve the affective response by reducing the reactivity of the amygdala and that practicing meditation leads to a reduction of physiological stress markers. However, it is also true that we are witnessing a trend that is not without confusion as well as an exponentially growing interest in mindfulness, in both the scientifi c and non-scientifi c fi elds. Conclusions: This paper aims to clarify the matter of concept, validity and psychological-psychiatric usefulness of full awareness or mindfulness currently and in the foreseeable future.

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“…However, some recent reviews on mindfulness and bipolar disorder have exhibited mixed results. Meta‐analysis of twelve trials by Chu et al () showed significantly beneficial effects on depressive and anxiety symptoms of bipolar disorder patients in within‐group analysis. However, this significance was not observed in comparison with the control groups.…”

Section: Introductionmentioning

confidence: 99%

Meditation for treating adults with bipolar disorder II: A multi‐city study

Pandya

2019

Clin Psychology and Psychoth

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There is a need to generate evidence on whether meditation's core aspect of building and nurturing calm and peace serves as a mood stabilizer for current and recurrent episodes of depression through the acute and maintenance phases of treating bipolar disorder II affected patients. A 2‐year longitudinal multi‐city randomized controlled trial experiment was conducted comprising 311 bipolar disorder II affected patients in the intervention and control group respectively across eight African and Asian cities. The Bipolar Depression Rating Scale (BDRS) was administered with the intervention and control groups that were equal at baseline. Meditation had a positive impact on the intervention group. Post intervention BDRS scores were significantly lower for patients from Asian cities, men, Hindus and Buddhists, middle class, and married patients as well as those who attended all the meditation rounds and regularly self‐practiced. Within the BDRS outcome measure, depressive symptoms were impacted the most as compared with mixed symptoms. Meditation helped alleviate guilt, depressed mood, and helplessness–hopelessness. The meditation programme can be used as a combination therapy along with pharmacological treatment to treat mood instability and depression among patients with bipolar disorder II.

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The effectiveness of adjunct mindfulness-based intervention in treatment of bipolar disorder: A systematic review and meta-analysis

Cited by 64 publications

References 55 publications

Stress and the psyche–brain–immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review

Stress and the psyche–brain–immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review

Full awareness or mindfulness in the practice of current clinical psychology and psychiatry: Explanatory contributions

Meditation for treating adults with bipolar disorder II: A multi‐city study

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