The effectiveness of acupuncture on HPA functional in depressed patients under methadone maintenance treatment, a randomized double-blind sham-controlled trial

Pirnia, Bijan; Pirnia, Kambiz; Mohammadpour, Samaneh; Malekanmehr, Parastoo; Mahmoodi, Zeinab; Soleimani, Ali Akbar; Zahiroddin, Alireza

doi:10.1016/j.ajp.2018.06.008

Cited by 14 publications

(12 citation statements)

References 5 publications

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“…Secondary outcomes also showed that acupuncture was associated with a reduction in suicidal ideation. In line with the primary outcomes of the present research, the use of acupuncture through promoting adrenocorticotropic hormone and the secretion of plasma cortisol led to regulation of HPA axis activity in the mice with asthma (4, 5, 7).…”

Section: Dear Editor-in-chiefsupporting

confidence: 82%

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The Effectiveness of Auricular Acupuncture on the Levels of Cortisol in a Depressed Patient

Pirnia¹,

Bazargan²,

Hamdieh³

et al. 2020

ijph

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Section: Dear Editor-in-chiefsupporting

confidence: 82%

“…1). Several studies have been conducted on the effectiveness of acupuncture on cortisol level (4, 5). Acupuncture has been associated with the regulation of HPA activity, improving the performance of adrenocorticotropic hormone and controlling of cortisol secretion (4).…”

Section: Dear Editor-in-chiefmentioning

confidence: 99%

The Effectiveness of Auricular Acupuncture on the Levels of Cortisol in a Depressed Patient

Pirnia¹,

Bazargan²,

Hamdieh³

et al. 2020

ijph

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“…In addition, the results of a study by Pirnia et al (11) indicated that acupuncture was associated with reduced cortisol and depression levels in depressed patients under methadone maintenance treatment.…”

Section: Discussionmentioning

confidence: 99%

“…2019; 13(2):e12498. rosine hydroxylase, increase the levels of dopamine, and reduce stress hormones such as cortisol, ultimately leading to the feeling of well-being (11).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Effectiveness of Auricular Acupuncture in Suicidal Ideation and Cortisol Level in Dysthymic Patients with Comorbid Opiate Use Disorders Enrolled in Methadone Maintenance Treatment: A Randomized, Double-Blind, Sham-Controlled Trial

Pirnia

Mohammadi

Zahiroddin

et al. 2019

Iran J Psychiatry Behav Sci

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Background: Suicide is one of the leading causes of death around the world. The hypothalamic-pituitary-adrenal (HPA) axis disorder is involved in the pathophysiology of suicidal behavior. Acupuncture by regulating the activity of the HPA axis could regulate the secretion of cortisol. Objectives: This study aimed to evaluate the effectiveness of auricular acupuncture in the reduction of cortisol level and suicidal ideation in dysthymic patients with comorbid opiate use disorders enrolled in methadone maintenance treatment (MMT). Methods: In a randomized, double-blind, sham-controlled trial (TCTR20180328001), from December 2015 to June 2016, 24 patients (mean age = 24 years) with persistent depressive disorder (dysthymia) under methadone maintenance treatment who referred to Bijan Center for Substance Abuse Treatment in Tehran were selected through respondent-driven sampling (RDS). After 28 days of evaluation, the participants were randomized into two active or sham continuous groups. Auricular acupuncture was performed twice a week for four weeks for the experimental group while the control group received the sham acupuncture. Assessments were carried out before treatment (baseline) and every week for four weeks. Salivary cortisol was considered the primary outcome and the suicide ideation was the secondary outcome. The data were analyzed by the generalized estimation equation (GEE) model and the chi-square test. The qualitative data were analyzed using ATLAS/TI 5 software. Results: Acupuncture had a significant effect on the cortisol level, as the primary outcome, during the four weeks of treatment. Moreover, there was a significant reduction in suicidal ideation as the secondary outcome (all P values < 0.01). Conclusions: Acupuncture as an alternative method could reduce the cortisol level and significantly decrease suicidal ideation.

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Hypothalamic-Pituitary-Adrenal Axis: A Bridge Between Acupuncture and Diseases

Zhu

Tian

2022

Advanced Acupuncture Research: From Bench to Bedside

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The effectiveness of acupuncture on HPA functional in depressed patients under methadone maintenance treatment, a randomized double-blind sham-controlled trial

Cited by 14 publications

References 5 publications

The Effectiveness of Auricular Acupuncture on the Levels of Cortisol in a Depressed Patient

The Effectiveness of Auricular Acupuncture on the Levels of Cortisol in a Depressed Patient

Evaluation of the Effectiveness of Auricular Acupuncture in Suicidal Ideation and Cortisol Level in Dysthymic Patients with Comorbid Opiate Use Disorders Enrolled in Methadone Maintenance Treatment: A Randomized, Double-Blind, Sham-Controlled Trial

Hypothalamic-Pituitary-Adrenal Axis: A Bridge Between Acupuncture and Diseases

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