The effectiveness of acupuncture as a treatment for tinnitus: a randomized controlled trial using 99mTc-ECD SPECT

Laureano, Maura Regina; Onishi, Ektor Tsuneo; Bressan, Rodrigo A.; Neto, Pedro Braga; Castiglioni, Mario Luiz Vieira; Batista, Ilza Rosa; Reis, Michel Silva; Garcia, Michele Vargas; Andrade, Adriana Neves de; Sanchez, Maura Lígia; Cogo-Moreira, Hugo; Almeida, Roberta Ribeiro de; Garrido, Griselda J.; Jackowski, Andrea Parolin

doi:10.1007/s00330-015-4164-7

Cited by 24 publications

(40 citation statements)

References 41 publications

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“…2,8 For example, in a randomized controlled study by Laureano et al, the efficacy of acupuncture therapy for patients with tinnitus was compared based on the THI scores of treated and untreated groups, and a statistically significant decrease was observed after treatment compared to the baseline values. 11 In another study including 50 patients with tinnitus, 8 the severity of the disease was monitored using the THI. The authors of that study reported that the THI score of the acupuncture group was reduced from 56 at baseline to 28 after treatment.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture Treatment in Patients with Chronic Subjective Tinnitus: A Prospective, Randomized Study

Kuzucu

Karaca

2020

Medical Acupuncture

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Objective: This study investigated the effect, onset, duration of action, and short-term outcomes of acupuncture therapy for treating patients with severe chronic subjective tinnitus. Materials and Methods: This randomized controlled trial evaluated patients with chronic, idiopathic, and severe tinnitus. A total of 105 participants were divided into 2 groups using a randomization method: a study group who received verum acupuncture therapy (n = 53) and a sham acupuncture group (n = 52). Ten acupuncture sessions were given over 5 weeks. After treatment, each participant was monitored for up to 3 months according to changes on a visual analogue Scale (VAS), and Tinnitus Handicap Inventory (THI), and Pure-Tone Audiometry and Speech Discrimination (Interacoustics AC-40, Denmark) scores. Results: The VAS and THI scores were evaluated. A statistically significant difference was noted between the sham and verum acupuncture groups at post-treatment follow-up (P < 0.001). Decreases in the THI and VAS scores became significant in the second week of treatment (P < 0.001 and P < 0.001, respectively), but these scores increased again in the third month post-treatment (P < 0.001 and P < 0.001, respectively). Conclusions: Acupuncture is an effective treatment for patients with severe chronic subjective tinnitus. Patient complaints, decreased beginning at the second treatment week; however, in the third post-treatment month, the complaints reappeared. Maintenance acupuncture therapy is necessary for patients with tinnitus; this approach should be investigated in future studies.

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Section: Discussionmentioning

confidence: 99%

Acupuncture Treatment in Patients with Chronic Subjective Tinnitus: A Prospective, Randomized Study

Kuzucu

Karaca

2020

Medical Acupuncture

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“…Finally, eight studies were included. [16][17][18][19][20][21][22][23] A flow diagram of the literature search and study selection is displayed in Figure 1.…”

Section: Study Selectionmentioning

confidence: 99%

“…Eight studies with 504 participants were included in this review. Four of the included studies were published in English, [16][17][18][19] and the remaining four studies were published in Chinese. [20][21][22][23] Two studies were conducted in Iran, 16,19 one study was conducted in Denmark, 17 one study was conducted in Brazil, 18 and the remaining four studies were Acupuncture in Medicine, 39 (4) conducted in China.…”

Section: Study Characteristicsmentioning

confidence: 99%

Acupuncture for tinnitus: a systematic review and meta-analysis of randomized controlled trials

et al. 2020

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Objective: To evaluate the efficacy/effectiveness of acupuncture for the treatment of tinnitus. Methods: Four English and four Chinese databases were searched for randomized controlled trials (RCTs) of acupuncture for tinnitus published before 30 September 2018. RCTs applying acupuncture alone compared with conventional treatments, sham acupuncture, or no treatment, as well as acupuncture plus conventional treatments compared with conventional treatments alone, were included. The primary outcome was the visual analogue scale (VAS). Secondary outcomes included tinnitus handicap inventory (THI) and tinnitus severity index (TSI) scores. Meta-analysis was conducted using RevMan V5.3 software. The protocol was registered in the PROSPERO database (ref. CRD42018108692). Results: Eight studies involving 504 participants were included. Meta-analysis showed no significant differences in the VAS score (mean difference (MD) = −1.81, 95% confidence interval (CI) = −3.69 to 0.07; p = 0.06) between the acupuncture and control groups. However, favorable effects of acupuncture on changes in THI score (MD = −10.11, 95% CI = −12.74 to −7.48; p < 0.001) and TSI score (MD = −8.36, 95% CI = −8.87 to −7.86; p < 0.001) were found. Conclusion: Acupuncture had no significant effect on the primary outcome of VAS score compared with control treatment; however, positive effects on secondary outcomes (THI and TSI score) were observed in acupuncture versus control groups. Due to the low quality and small sample size of the included trials, the level of evidence was insufficient to draw any definitive conclusions. Further rigorous and high-quality studies with larger sample sizes should be conducted to confirm the efficacy/effectiveness of acupuncture for tinnitus.

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“…Some studies have found that electroacupuncture stimulation of ST25 significantly reduces glucose metabolism in the left cingulate gyrus, right insula, right parahippocampal gyrus, anterior fascicle and right caudate nucleus in patients with GI dysfunction. It was found that bilateral thalamic blood flow decreases significantly after electroacupuncture therapy, indicating that the mechanism of action of electroacupuncture therapy on IBS is related to the decrease in blood flow in specific brain regions [36]. In previous studies, this team has also found that in healthy volunteers after electroacupuncture, ST36 magnetoencephalography reveals that acupuncture stimulation on the foot three mile point leads to a wide range of the cerebral cortex and that the limbic system and subcortical area signal continues to increase, which can directly affect the CNS [12] .…”

Section: Discussionmentioning

confidence: 99%

TEAS treatment improves gastrointestinal function after abdominal surgery: study protocol for a prospective randomized controlled trial

Bai

Gao²,

et al. 2020

Preprint

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Background : Postoperative gastrointestinal (GI) dysfunction (PGD) is a common problem after abdominal surgery. PGD can increase the length of hospital stay and the economic burden and may even lead to some serious complications. Acupuncture and moxibustion are alternative therapies recommended for PGD. However, the effect of preventive application of acupuncture or transcutaneous electrical acupuncture stimulation (TEAS) is still uncertain. The purpose of this study is to investigate the efficacy of the continuous application of TEAS on GI function recovery in patients after abdominal surgery. At the same time, we will try to confirm the mechanism of TEAS through the brain-gut axis.Methods/design : This study is a prospective, single-center, two-arm, randomized controlled trial that will be performed in a general hospital. In total, 280 patients scheduled for gastric or colorectal cancer surgery will be stratified into two groups. The experimental group will receive TEAS stimulation at Hegu (L14) and Neiguan (PC6), Zusanli (ST36), and Shangjuxu (ST37) once a day for 30 min during and after surgery until GI function recovery. The sham group will receive pseudo-TEAS at sham acupoints. The primary outcome will be the recovery time of postoperative bowel sounds, flatus, bowel movements and the changes in perioperative brain-intestinal peptides. The secondary outcome will be postoperative pain, perioperative complications, and hospitalization duration.Discussion : The results of this study will demonstrate that continuous preventive application of TEAS can improve the GI function recovery in patients undergoing abdominal surgery and that this effect may act through brain-gut peptides.Trial registration: Chinese Clinical Trial Registry, ID: ChiCTR1900023263, Registered on 11 May 2019,http://www.chictr.org.cn

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The effectiveness of acupuncture as a treatment for tinnitus: a randomized controlled trial using 99mTc-ECD SPECT

Cited by 24 publications

References 41 publications

Acupuncture Treatment in Patients with Chronic Subjective Tinnitus: A Prospective, Randomized Study

Acupuncture Treatment in Patients with Chronic Subjective Tinnitus: A Prospective, Randomized Study

Acupuncture for tinnitus: a systematic review and meta-analysis of randomized controlled trials

TEAS treatment improves gastrointestinal function after abdominal surgery: study protocol for a prospective randomized controlled trial

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