The effectiveness of a nurse-led exercise and health education informatics program on exercise capacity and quality of life among cancer survivors after esophagectomy: A randomized controlled trial

Chang, Yu‐Ling; Tsai, Yun‐Fang; Hsu, Chien Lung; Chao, Yin‐Kai; Hsu, Chih Chin; Lin, Kuan Chia

doi:10.1016/j.ijnurstu.2019.103418

Cited by 38 publications

(81 citation statements)

References 50 publications

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“…In line with the findings of the present study, previous studies 20,22,30 have demonstrated that exercise in the postoperative period and after completion of treatment can improve cardiorespiratory fitness in patients with gastro‐oesophageal cancer, although the role of high‐intensity exercise has not been explored previously during adjuvant chemotherapy. An important finding was the relatively good adherence to exercise training during adjuvant chemotherapy, which is often poorly tolerated compared with neoadjuvant treatment 2 .…”

Section: Discussionsupporting

confidence: 89%

“…In the postoperative setting, patients are recovering from major surgery and many will be undergoing adjuvant chemotherapy. Only two studies 21,22 have investigated the effect of exercise training in the postoperative period, concurrently with adjuvant treatment in one of these. Both studies used low to moderate intensity, home‐based, unsupervised interventions.…”

Section: Introductionmentioning

confidence: 99%

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Effects of high-intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro-oesophageal junction: PRESET pilot study

et al. 2020

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Background: Treatment for cancer of the gastro-oesophageal junction (GOJ) can result in considerable and persistent impairment of physical fitness and health-related quality of life (HRQoL). This controlled follow-up study investigated the feasibility and safety of postoperative exercise training. Methods: Patients with stage I-III GOJ cancer were allocated to 12 weeks of postoperative concurrent aerobic and resistance training (exercise group) or usual care (control group). Changes in cardiorespiratory fitness, muscle strength and HRQoL were evaluated. Adherence to adjuvant chemotherapy, hospitalizations and 1-year overall survival were recorded to assess safety. Results: Some 49 patients were studied. The exercise group attended a mean of 69 per cent of all prescribed sessions. After exercise, muscle strength and cardiorespiratory fitness were increased and returned to pretreatment levels. At 1-year follow-up, the exercise group had improved HRQoL (+13⋅5 points, 95 per cent c.i. 2⋅2 to 24⋅9), with no change in the control group (+3⋅7 points, −5⋅9 to 13⋅4), but there was no difference between the groups at this time point (+9⋅8 points, −5⋅1 to 24⋅8). Exercise was safe, with no differences in patients receiving adjuvant chemotherapy (14 of 16 versus 16 of 19; relative risk (RR) 1⋅04, 95 per cent c.i. 0⋅74 to 1⋅44), relative dose intensity of adjuvant chemotherapy (mean 57 versus 63 per cent; P = 0⋅479), hospitalization (7 of 19 versus 6 of 23; RR 1⋅41, 0⋅57 to 3⋅49) or 1-year overall survival (80 versus 79 per cent; P = 0⋅839) for exercise and usual care respectively. Conclusion: Exercise in the postoperative period is safe and may have the potential to improve physical fitness in patients with GOJ cancer. No differences in prognostic endpoints or HRQoL were observed. Registration number: NCT02722785 (https://www.clinicaltrials.gov).

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effects of high-intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro-oesophageal junction: PRESET pilot study

et al. 2020

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“…The study characteristics of the six included studies are outlined in Table 1 . The included studies comprise three randomised control trials (RCTs) [ 5 , 6 , 24 ], two single arm feasibility studies [ 21 – 23 ], and one protocol for an RCT [ 25 ]. All included studies were published between 2017 and 2020.…”

Section: Resultsmentioning

confidence: 99%

“…Four of the studies included participants who had oesophageal cancer only [ 6 , 21 , 22 , 24 , 25 ], one study included participants who had gastric cancer only [ 23 ], and one study included participants who had either oesophageal, oesophageal junction, or gastric cancers [ 5 ]. Surgery was used as a treatment technique in all studies.…”

Section: Resultsmentioning

confidence: 99%

“…Study participants were supervised by physiotherapists or exercise specialists, and/or were prescribed home-based programmes following pre-intervention training by physiotherapists or exercise specialists. Three of the six studies delivered the exercise interventions as part of a multidisciplinary rehabilitation programme, which included input from other multidisciplinary team members such as nurses and dietitians [ 5 , 6 , 21 , 22 ] (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

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Identifying outcomes reported in exercise interventions in oesophagogastric cancer survivors: a systematic review

et al. 2021

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Background Research investigating exercise interventions in oesophagogastric cancer survivors is sparse, and the outcomes are varied. The aim of this systematic review is to identify the domains and outcomes reported in exercise interventions in oesophagogastric cancer survivors to be included in a Delphi study, with a view to informing the development of a core outcome set (COS). Methods EMBASE, PubMed, CINHAL, Cochrane Library, SCOPUS, and PEDro were searched up to March 2020 using a predefined search strategy. The outcomes identified during data extraction were categorised using the core areas outlined in the OMERACT Filter 2.0. Results Fourteen domains and 63 outcomes were identified. The most frequently reported outcomes were in the domains of quality of life using the EORTC-QLQ-C30 questionnaire and the relevant disease-specific modules (100%), exercise capacity/fitness/physical function (100%), anthropometrics (83.33%), physical activity (66.67%), and biomarker analysis (50%). Conclusion This systematic review quantifies and describes the domains and outcomes examined in exercise interventions in oesophagogastric cancer survivors. Some inconsistency exists within the domains and outcomes used, and little attention was given to nutritional or economic endpoints. In order to develop a COS, a Delphi consensus process with key stakeholders is needed to identify the relevant domains and outcomes for inclusion.

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Home‐based physical activity after treatment for esophageal cancer—A randomized controlled trial

et al. 2022

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Background The treatment of most esophageal cancer patients includes chemo(radio)therapy and extensive surgery, causing physical decline with loss of muscles. This trial aimed to test the hypothesis that a tailored home‐based physical activity (PA) intervention improves muscle strength and mass in patients having undergone curative treatment for esophageal cancer. Methods Patients operated for esophageal cancer 1 year earlier were included in a nationwide randomized controlled trial in Sweden in 2016–2020. The intervention group was randomized to a 12‐week home‐based exercise program, while the control group was encouraged to maintain routine daily PA. The primary outcomes were changes in maximal/average hand grip strength measured with hand grip dynamometer and lower extremity strength measured using 30‐second chair stand test and muscle mass measured using a portable bio‐impedance analysis monitor. Intention‐to‐treat analysis was used, and results were presented as mean differences (MDs) with 95% confidence intervals (CIs). Results Among 161 randomized patients, 134 completed the study, 64 in the intervention group and 70 in the control group. Compared with the control group (MD 2.73; 95% CI 1.75–3.71), patients in the intervention group (MD 4.48; 95% CI 3.18–5.80) had statistically significantly ( p = 0.03) improved lower extremity strength. No differences were seen for hand grip strength or muscle mass. Conclusion A home‐based PA intervention 1 year after surgery for esophageal cancer improves lower extremity muscle strength.

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The effectiveness of a nurse-led exercise and health education informatics program on exercise capacity and quality of life among cancer survivors after esophagectomy: A randomized controlled trial

Cited by 38 publications

References 50 publications

Effects of high-intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro-oesophageal junction: PRESET pilot study

Effects of high-intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro-oesophageal junction: PRESET pilot study

Identifying outcomes reported in exercise interventions in oesophagogastric cancer survivors: a systematic review

Home‐based physical activity after treatment for esophageal cancer—A randomized controlled trial

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