The effectiveness of 2 consecutive intra-articular polydeoxyribonucleotide injections compared with intra-articular triamcinolone for hemiplegic shoulder pain

Abstract

The aim of this study was to investigate the effects of intra-articular injection of polydeoxyribonucleotide (PDRN), compared with intraarticular triamcinolone (TA) injection, in subacute stroke patients with hemiplegic shoulder pain (HSP).Participants were subacute stroke patients with HSP who had undergone 2 consecutive intra-articular injections of TA or PDRN.Numeric rating scale (NRS) and passive range of motion (PROM) of hemiplegic shoulder were evaluated until 4 weeks after 2nd injection.In the results, there were significant improvements in all PROM measures 2 weeks after the second injection, compared with pre-injection results, in both groups (P < .05). In the PDRN group, however, none of the PROM measures were significantly improved at 3 and 4 weeks after the second injection, compared with pre-injection results (P ≥ .05). When comparing pre-injection results with those at 4 weeks after the second injection, all PROM and NRS measures in the TA group were more improved than in the PDRN group, but this was not statistically significant (P ≥ .05).In conclusion, considering the systemic side effects of steroids, especially among patients with diabetes or metabolic syndrome, PDRN seems to be a worthwhile treatment option for HSP, although PDRN does not seem to have an equivalent persistence effects when compared with TA.

Full recovery of near complete tear of anterior cruciate ligament without surgery: a case report

“…Even though PDRN does not seem to have an equivalent persistence effect compared to triamcinolone, considering the systemic side effects of steroids, particularly in patients with diabetes or metabolic syndrome, it appears that PDRN is worthwhile as an option for the treatment of hemiplegic shoulder pain. [ 14 ] Mun et al [ 13 ] reported the effectiveness of PDRN injection on pes anserinus bursitis. Lim et al [ 11 ] reported the effectiveness of PDRN injection in posterior tibial tendon dysfunction patients undergoing ankle syndesmotic surgery.…”

Polydeoxyribonucleotide Regulation of Inflammation

“…78 Moreover, PDRN had a similar anti-inflammatory effect in subacute stroke patients with hemiplegic shoulder pain, suggesting that it could be a valid alternative for this musculoskeletal complication due to its increased safety. 79 PDRN could also be a valid alternative to corticosteroids for lateral epicondylitis (LE) treatment. 80 After undergoing ultrasound-guided PDRN injection, two patients reported improvements in LE symptoms and complete resolution of hypervascularity without complications.…”

Ultrasound-guided peri-brachial plexus polydeoxyribonucleotide injection for a patient with postherpetic brachial plexopathy

“…[3] However, it's use may be limited because of various side effects, such as adrenal suppression, glucocorticoid-induced osteoporosis, and cognitive and mood disorders. [4] Recently, polydeoxyribonucleotide (PDRN) has been reported as a viable substitute for corticosteroids in various musculoskeletal disorders. [4–8] Here, we reported a case of a patient with brachial plexopathy following HZ (postherpetic brachial plexopathy), who showed improvement after administration of ultrasound-guided PDRN injection around the brachial plexus.…”