Anesthesia &Amp; Analgesia
 2016
DOI: 10.1213/ane.0000000000001070
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The Effectiveness and Stability of a 20% Emulsified Sevoflurane Formulation for Intravenous Use in Rats

Toru Morohashi
1
,
Sayako Itakura
2
,
Ken‐ichi Shimokawa
3
et al.

Abstract: We prepared a 20% sevoflurane lipid emulsion using caprylic triglyceride (i.e., medium-chain triglyceride). In rats, this emulsion was an effective anesthetic and was not associated with adverse events. The emulsion was stable after consecutive evaluation for 365 days and for 180 minutes after the vial was opened.

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Cited by 5 publications
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A Multicenter, Randomized, Double-Blind, Positive-Controlled, Non-Inferiority, Phase III Clinical Trial Evaluating the Efficacy and Safety of Emulsified Isoflurane for Anesthesia Induction in Patients

Yang
1
,
Zhang
2
,
Liu
3
et al. 2022
CNS Drugs
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A Multicenter, Randomized, Double-Blind, Positive-Controlled, Non-Inferiority, Phase III Clinical Trial Evaluating the Efficacy and Safety of Emulsified Isoflurane for Anesthesia Induction in Patients

Yang
1
,
Zhang
2
,
Liu
3
et al. 2022
CNS Drugs
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New Hypnotic Drug Development and Pharmacologic Considerations for Clinical Anesthesia

Tanious
1
,
Beutler
2
,
Kaye
3
et al. 2017
Anesthesiology Clinics
23
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Rapid quantification of isoflurane in anesthetic nanoemulsions using Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR)

Tootoonchi
1
,
Bardsley2,
Panagiotou3
et al. 2020
Vibrational Spectroscopy
1
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0
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