The Effectiveness and Prognostic Factors of CT-Guided Radioactive I-125 Seed Implantation for the Treatment of Recurrent Head and Neck Cancer After External Beam Radiation Therapy

Efficacy and safety of CT-guided 125I seed implantation as a salvage treatment for locally recurrent head and neck soft tissue sarcoma after surgery and external beam radiotherapy: A 12-year study at a single institution

“…recurrence than those with stage lower than T4, which indicated that invasion of adjoining structures was more likely to affect the LPFS than tumor size. Previous studies showed that the radiation dose was a significantly independent prognostic factor of the efficacy in most cancers including head and neck squamous carcinoma, cervical cancer, and so on (8,9). Similar results were not observed in our work, which may be due to the limited sample size.…”

“…There is an increasing number of studies recently demonstrating that RIS implantation, a type of low-dose-rate brachytherapy, characterized by delivering high radiation dose to tumor target while safely sparing the adjacent normal tissue, is an effective salvage treatment for most recurrent cancers, including prostate cancer, lung cancer, pancreatic cancer, rectal cancer, cervical cancer, head and neck cancer, and so on (7). Our previous work has showed its good efficacy as a salvage treatment for recurrent cervical cancer (8); head and neck cancer (9); and rectal cancer (10); which therefore has been referenced by NCCN Guidelines of Rectal Cancer 2015.v2 as a recommendation for locally recurrent rectal carcinoma (11). To some extent, RIS implantation is similar to single dose of stereotactic ablative radiotherapy and also can be called "stereotactic ablative brachytherapy".…”

The Accuracy of Individualized Three Dimensional-printing Template Assisted I125 Radioactive Seed Implantation for Recurrent head and Neck Cancer

“…Dosimetry parameters including D90, D100, V100, V150, V200, CI, EI, and HI were evaluated. All RSI procedures were performed in accordance with relevant guidelines and regulations, as also described in published study [7,12].…”

“…As the standard option for early stage prostate cancer, I 125 radioactive seed implantation (RSI) is also commonly used for recurrent head and neck cancer, providing a high local tumor control and preservation of organ functions [1,6,7]. While the deviation between planned and intraoperative needle pass way may occur even under the image guidance of Ultrasound, Computerized Tomography(CT), and Magnetic Resonance Imaging(MRI), leading to the mis-implantation of radiative seeds and unnecessary radiation or damage of surrounding critical organs and tissues.…”

“…However, most of the previous studies involving 3D-PT assisted I 125 RSI were focused on the e cacy and safety pro les, mainly including local control, survival and complications [7,[11][12][13]. As the mean entrance deviation, planned and intraoperative deviation of needle depth and angular were deemed to represent the accuracy of needle related interventions, only 2 studies involving these parameters were published to described the accuracy of 3D-PT assisted I 125 RSI for head and neck cancer [9,14].…”