The effective use of isoconazole nitrate and diflucortolone valerate cream in the treatment of inguino‐femoral skin fold mycosis

Inflammatory tinea pedis with bacterial superinfection effectively treated with isoconazole nitrate and diflucortolone valerate combination therapy

“…As seen in previous case reports, a 2‐week treatment regimen with Travocort cream (containing the imidazole ISN 0.1% and the corticosteroid diflucortolone valerate) was effective in improving the clinical signs of tinea pedis and in alleviating the symptoms that most impacted the patient's QoL. Furthermore, the regimen was safe for use in patients with diabetes consistent with previous reports . ISN has a broad spectrum of antimicrobial activity against dermatophytes, pathogenic yeasts, filamentous fungi, moulds and gram‐positive bacteria .…”

Antifungal Combinations in Dermatophytes

“…The results of antifungal combinations in humans are reported in Table 3 . There were 25 papers describing 37 single case reports, one paper each describing 36 and 254 patients, respectively, and 3 clinical trials involving a total of 410 patients [ 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ]. Either paediatric or adult patients were represented.…”

The association topical antifungals/topical corticosteroids in superficial mycoses of the skin: A critical review of the literature and personal experience

“…Although the clinical results of all these studies were considered as satisfactory, it was observed that, by means of the Warburg assay, antifungal activity of clotrimazole, econazole and ketoconazole was significantly impaired when triamcinolone acetonide or prednisolone‐21‐hemisuccinate‐sodium at high concentrations (10–25 times higher than the concentrations of imidazoles) were present in the test flasks 13 . Since 2008, the most studied combination was isoconazole/diflucortolone 14–35 . In particular, two sponsor‐free studies were carried out at the Dermatology Unit of the University of Milan in patients with tinea cruris 27 and tinea corporis 35 .…”

“…This study in atopic children with tinea corporis superinfected by S. aureus confirmed that the association isoconazole/diflucortolone was useful and safe. Anecdotic cases of patients successfully treated with this combination were reported in tinea faciei , 31,33 tinea corporis , 19–21,31–33 tinea cruris , 16–18,33 tinea pedis , 25,26,30 intertrigo 22–24,34 and balanitis by Candida albicans 24 …”

“…This study in atopic children with tinea corporis superinfected by S. aureus confirmed that the association isoconazole/diflucortolone was useful and safe. Anecdotic cases of patients successfully treated with this combination were reported in tinea faciei, 31,33 tinea corporis, [19][20][21][31][32][33] tinea cruris, [16][17][18]33 tinea pedis, 25,26,30 intertrigo [22][23][24]34 and balanitis by Candida albicans. 24 According to literature data and our personal clinical experience, a topical therapy with a combination of an antifungal and a corticosteroid can be useful for several reasons: (a) topical corticosteroids induce a rapid improvement of inflammatory signs (erythema and swelling) and itching, that are very frequently associated with some epidermophytoses, such as tinea corporis in atopic children and tinea cruris: this swift improvement of itching encourages patients' adherence and compliance to treatment; (b) the increased bioavailability of the antifungal in the skin, when applied with a topical corticosteroid: due to the local vasoconstrictive action of the corticosteroid, the dispersal of the imidazole via the circulation is delayed.…”