The effect on heart rate of distending the atrial appendages in the dog

Kappagoda, C. T.; Linden, R. J.; Saunders, D. A.

doi:10.1113/jphysiol.1972.sp009965

Cited by 45 publications

(29 citation statements)

References 11 publications

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“…A third balloon was inserted into the left atrial appendage (Kappagoda et al 1972). A cannula (PE 260, Intramedic, Pasipanny, NJ, U.S.A.) was inserted into the atrium through the appendage so as to record the atrial pressure.…”

Section: Methodsmentioning

confidence: 99%

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Effects of combined carotid chemoreceptor and atrial receptor stimulation on renal blood flow in anaesthetized dogs.

Kappagoda¹,

Karim²,

MacKay³

1983

The Journal of Physiology

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SUMMARY1. In dogs anaesthetized with chloralose and artificially ventilated, carotid chemoreceptors were stimulated by changing the perfusate of the vascularly isolated carotid bifurcations from arterial to venous blood. Left atrial receptors were stimulated by distending balloons in two pulmonary vein-left atrial junctions and in this left atrial appendage.2. The left renal blood flow was measured by an electromagnetic flow meter at a constant systemic (renal) arterial pressure in preparations in which heart rate changes were prevented by administration of propranolol hydrochloride (0-5 mg kg-') and atropine sulphate (0-4 mg kg-'). Muscular movement was prevented by gallamine triethiodide (0-2 mg kg-').3. Stimulation of left atrial receptors resulted in a significant increase (P < 0-001)in renal blood flow of 5-6 + 0'88 ml min' 100 g-renal mass from a control of 223 ml min' 100 g-' renal mass. The responses were abolished by cooling the cervical vagus nerves to 6-8 'C. 4. Stimulation of carotid chemoreceptors, by perfusion of the carotid bifurcations by venous blood, caused a decrease in renal blood flow of 20+ 6-9 ml min' 100 g-' renal mass from 224 ml min' 100 g-' renal mass. Stimulation of left atrial receptors during venous perfusion of carotid chemoreceptors resulted in an increase in renal blood flow of 10-9 + 1-82 ml min' 100 g-1 renal mass from 208 ml min' 100 g-1 renal mass.5. These results show that atrial receptors and chemoreceptors can interact in their effects on renal blood flow.

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Section: Methodsmentioning

confidence: 99%

“…The chemoreceptors were stimulated by perfusion of the isolated carotid bifurcations with venous blood and atrial receptors by localized stretch of the pulmonary vein-atrial junctions (Ledsome & Linden, 1964) and the atrial appendage (Kappagoda, Linden & Saunders, 1972).…”

Section: Introductionmentioning

confidence: 99%

Effects of combined carotid chemoreceptor and atrial receptor stimulation on renal blood flow in anaesthetized dogs.

Kappagoda¹,

Karim²,

MacKay³

1983

The Journal of Physiology

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“…This technique has been shown to stimulate left atrial receptors (Kidd, Ledsome & Linden, 1978) and has enabled Linden and his colleagues to define the reflex effects of stimulating such receptors in the anaesthetized dog. Stimulation of these receptors results in a reflex tachycardia (Furnival et al 1971) and an increase in urine flow (Ledsome & Linden, 1968) but no consistent changes in arterial blood pressure (Ledsome & Linden, 1964), peripheral resistance (Carswell, Hainsworth & Ledsome, 1970) or the pattern of breathing ) Subsequent work has shown that the distension of the atrial appendages (Kappagoda, Linden & Saunders, 1972b) and the junctions between the venae cavae and the right atrium (Kappagoda, Linden & Snow, 1972 a) also results in an increase in the heart rate.…”

Section: Introdtictionmentioning

confidence: 99%

The Effects of Stimulation of the Left Atrial Receptors in the Cat

1982

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SUMMARYIn the cat, distension of the left atrial appendages by means of small balloons resulted in variable changes in the heart rate. Distension of the junctions between the upper two left pulmonary veins and the left atrium resulted in a small but statistically significant increase in the heart rate. Distension did not result in any significant changes in the blood pressure. The increases in heart rate are far less than observed in the dog and it is suggested that the atrial receptors might play a less important role in cardiovascular control in the cat than they do in the dog. INTRODTICTION

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“…A quantitative analysis of atrial natriuretic peptides (ANP) contained in excised LAAs revealed a content of approximately 30% of all cardiac ANP (Chapeau et al, 1985). Experimental studies have demonstrated that infusion of fluid in the LAA result in increased heart rate, diuresis and natriuresis; this further supports a significant role of the LAA in regulating normal cardiac physiology (Kappagoda et al, 1972a, Kappagoda et al, 1972b. The LAA has a distinct pattern of contraction, and shortens to a greater extent than the rest of the left atrium.…”

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confidence: 77%