The effect on cadaver blood DNA identification by the use of targeted and whole body post-mortem computed tomography angiography

Rutty, Guy N.; Barber, J.; Amoroso, Jasmin; Morgan, Bruno; Graham, Eleanor A. M.

doi:10.1007/s12024-013-9467-x

Cited by 11 publications

(2 citation statements)

References 19 publications

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“…Only a few studies have investigated the influence of different contrast media. The available studies pertain exclusively to MPMCTA and TCA and their influence on toxicology [41,42], biochemistry [43], microbiology [44], genetics [45], histology, and fatty embolism evaluation [46,47]. Therefore, the recommendation remains that as many specimens as possible should be sampled prior to injection of the contrast medium, as described by Schneider et al [48].…”

Section: Oily Contrast Agent Mixturementioning

confidence: 99%

Application of contrast media in post-mortem imaging (CT and MRI)

et al. 2015

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The application of contrast media in post-mortem radiology differs from clinical approaches in living patients. Post-mortem changes in the vascular system and the absence of blood flow lead to specific problems that have to be considered for the performance of post-mortem angiography. In addition, interpreting the images is challenging due to technique-related and post-mortem artefacts that have to be known and that are specific for each applied technique. Although the idea of injecting contrast media is old, classic methods are not simply transferable to modern radiological techniques in forensic medicine, as they are mostly dedicated to single-organ studies or applicable only shortly after death. With the introduction of modern imaging techniques, such as post-mortem computed tomography (PMCT) and post-mortem magnetic resonance (PMMR), to forensic death investigations, intensive research started to explore their advantages and limitations compared to conventional autopsy. PMCT has already become a routine investigation in several centres, and different techniques have been developed to better visualise the vascular system and organ parenchyma in PMCT. In contrast, the use of PMMR is still limited due to practical issues, and research is now starting in the field of PMMR angiography. This article gives an overview of the problems in post-mortem contrast media application, the various classic and modern techniques, and the issues to consider by using different media.

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Section: Oily Contrast Agent Mixturementioning

confidence: 99%

Application of contrast media in post-mortem imaging (CT and MRI)

et al. 2015

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“…There is more flexibility in the use of contrast agents in PMCT as toxicity is not a concern, although some consideration has to be taken of the effect of any contrast medium on subsequent toxicology or DNA examination. [68][69][70] Generally, these can be lipophilic agents (dissolved in oil), barium particles in suspension or water-soluble iodinated chelates. 6 Agents, such as air or fat, that lower X-ray attenuation and appear black on traditional CT images may also be used as negative contrast agents ( Figure 3).…”

Section: Traumatic Death and Identificationmentioning

confidence: 99%

Adult post-mortem imaging in traumatic and cardiorespiratory death and its relation to clinical radiological imaging

Morgan¹,

Adlam²,

Robinson³

et al. 2014

BJR

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The use of post-mortem imaging is expanding throughout the world with increasing use of advanced imaging techniques, such as contrast-enhanced CT and MRI. The questions asked of post-mortem imaging are complex and can be very different, for example for natural sudden death investigation will focus on the cause, whereas for trauma the cause of death is often clear, but injury patterns may be very revealing in investigating the background to the incident. Postmortem imaging is different to clinical imaging regarding both the appearance of pathology and the information required, but there is much to learn from many years of clinical research in the use of these techniques. Furthermore, it is possible that post-mortem imaging research could be used not only for investigating the cause of death but also as a model to conduct clinically relevant research. This article reviews challenges to the development of post-mortem imaging for trauma, identification and cardiorespiratory death, and how they may be influenced by current clinical thinking and practice.

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