The Effect on Bone Outcomes of Adding Exercise to Supplements for Osteopenic Breast Cancer Survivors

Kim, Soo Hyun; Cho, Young Up; Kim, Sei Joong; Hong, Seongbin; Han, Mi Sook; Choi, Eunju

doi:10.1097/ncc.0000000000000245

Cited by 18 publications

(68 citation statements)

References 38 publications

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“…With regard to other studies in the field of PRT in BC patients (Cheema et al., ; Simonavice et al., ; Kim et al., ) the comparability of reported increase in muscle strength measured by gold standard procedures vs 1RM testing seems to be limited. For example, a 3‐month moderate‐ to high‐intensity PRT conducted by Cormie et al.…”

Section: Discussionmentioning

confidence: 94%

Effects of 12‐week resistance training during radiotherapy in breast cancer patients

Wiskemann

Schmidt

Klassen

et al. 2016

Scandinavian Med Sci Sports

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Exercise is considered to be an effective supportive treatment approach in breast cancer (BC) patients. We conducted a randomized controlled trial to assess the efficacy of a 12-week PRT during radiotherapy. Strength performance was assessed by maximal isokinetic peak torque (MIPT) in two different angular velocities (60°/s and 180°/s) and maximal voluntary isometric contraction for shoulder external and internal rotation, as well as for knee extension and flexion were assessed pre- and post-intervention in 146 patients randomized to PRT or a control group. Statistical analyses were based on analysis of covariance models for the individual changes from baseline to week 13. Intention-to-treat analyses showed significant between-group differences favoring the exercise group (EX) for MIPT in knee flexion and shoulder internal and external rotation (P < 0.05). Subgroup analyses showed borderline significant differences with regard to pretreatment history, revealing that pretreated chemotherapy patients tend to benefit more from PRT than patients without chemotherapy (P = 0.06). Strength gain at the operated arm was significantly higher than at the non-operated arm in EX. PRT was efficacious in increasing upper and lower limb strength in BC patients undergoing adjuvant radiotherapy. Patients with restrictions due to breast cancer-related surgery and pretreated with chemotherapy might benefit the most.

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Section: Discussionmentioning

confidence: 94%

Effects of 12‐week resistance training during radiotherapy in breast cancer patients

Wiskemann

Schmidt

Klassen

et al. 2016

Scandinavian Med Sci Sports

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“…High-intensity resistance and weight-bearing training have been shown to reduce bone loss in healthy pre-and postmenopausal women [11][12][13][14]. Much less is known about the skeletal benefits of exercise among breast cancer survivors, but a few exercise intervention studies have been carried out with varying results [15][16][17][18][19][20][21][22][23][24]. To our knowledge, the current BREX (Breast Cancer and Exercise) study is the largest prospective exercise intervention study on breast cancer survivors.…”

Section: Introductionmentioning

confidence: 99%

Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients

et al. 2020

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A 12-month exercise program reversibly prevented hip bone loss in premenopausal women with early breast cancer. The bone-protective effect was maintained for 2 years after the end of the program but was lost thereafter. Purpose Breast cancer survivors are at an increased risk for osteoporosis and fracture. This 5-year follow-up of a randomized impact exercise intervention trial evaluated the maintenance of training effects on bone among breast cancer patients. Methods Five hundred seventy-three early breast cancer patients aged 35-68 years and treated with adjuvant therapy were allocated into a 12-month exercise program or a control group. Four hundred forty-four patients (77%) were included in the 5year analysis. The exercise intervention comprised weekly supervised step aerobics, circuit exercises, and home training. Areal bone mineral density (aBMD) was measured by dual-energy X-ray absorptiometry. Physical activity was estimated in metabolic equivalent (MET) hours per week and physical performance assessed by 2-km walking and figure-8 running tests. Results In premenopausal patients, the 12-month exercise program maintained femoral neck (FN) and total hip (TH) aBMD for 3 years, but the protective effect was lost thereafter. The mean FN aBMD change in the exercise and control groups was − 0.2% and − 1.5% 1 year, − 1.1% and − 2.1% 3 years and − 3.3% versus − 2.4% 5 years after the beginning of the intervention, respectively. Lumbar spine (LS) bone loss was not prevented in premenopausal women and no training effects on aBMD were seen in postmenopausal women. The main confounding element of the study was the unexpected rise in physical activity among patients in the control group. The physical performance improved among premenopausal women in the exercise group compared with the controls. Conclusion The 12-month exercise program prevented FN and TH bone loss in premenopausal breast cancer patients for 3 years. The bone-protective effect was reversible and lost thereafter.

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“… 10 Exercise interventions that involve an increased loading on the bone such as resistance training, jumping activity, and other weightbearing activities, have also been shown to improve bone density in pre- and postmenopausal women when performed regularly. 11 However, research to date regarding the role of exercise for bone health in breast cancer survivors reports poor intervention adherence, 12 - 15 as well as a lack of evidence for improvements in bone mineral density. 12 - 17 Investigation of other supportive care interventions aimed at decreasing bone resorption in breast cancer patients on aromatase inhibitors is required.…”

Section: Introductionmentioning

confidence: 99%

Whole Body Vibration Exposure on Markers of Bone Turnover, Body Composition, and Physical Functioning in Breast Cancer Patients Receiving Aromatase Inhibitor Therapy: A Randomized Controlled Trial

et al. 2018

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Introduction: Women with breast cancer are often prescribed aromatase inhibitors, which can cause rapid loss of bone mass leading to significant potential for morbidity. Vibration training has been shown to be helpful in reducing bone turnover in postmenopausal women without cancer. Aim: To examine the effect of vibration stimulus on markers of bone turnover in breast cancer patients receiving aromatase inhibitors. Methods: Thirty-one breast cancer survivors undergoing treatment with aromatase inhibitors were randomized to vibration stimulus (n = 14) or usual care control (n = 17). Low-frequency and low-magnitude vibration stimulus (27-32 Hz, 0.3g) was delivered in supervised sessions via standing on a vibration platform for 20 minutes, 3 times per week for 12 weeks. The primary outcome was blood markers of bone resorption (serum N-telopeptide X/creatine) and formation (serum type 1 procollagen N-terminal propeptide; P1NP). Other study outcomes body composition as well as measures of physical functioning. Outcomes were compared between groups using analysis of covariance adjusted for baseline values as well as time on aromatase inhibitors. Outcomes: On average, participants were 61.5 years old and overweight (ie, body mass index = 28.5 kg/m2). Following vibration training, there was no significant difference between groups for bone resorption (adjusted group difference 0.5, P = .929) or formation (adjusted group difference 5.3, P = .286). There were also no changes in any measure of physical functioning body composition. Conclusions: Short-term low-magnitude vibration stimulus does not appear to be useful for reducing markers of bone turnover secondary to aromatase inhibitors in breast cancer patients; nor is it useful in improving physical function or symptoms. However, further investigations with larger samples and higher doses of vibration are warranted. Trial Registration: Australian and New Zealand Clinical Trials Registry (ACTRN12611001094965).

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The Effect on Bone Outcomes of Adding Exercise to Supplements for Osteopenic Breast Cancer Survivors

Abstract: Effective exercise intervention may require more intensive components such as higher loading forces and longer duration for improving bone health among this population.

Cited by 18 publications

References 38 publications

Effects of 12‐week resistance training during radiotherapy in breast cancer patients

Effects of 12‐week resistance training during radiotherapy in breast cancer patients

Five-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients

Whole Body Vibration Exposure on Markers of Bone Turnover, Body Composition, and Physical Functioning in Breast Cancer Patients Receiving Aromatase Inhibitor Therapy: A Randomized Controlled Trial

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