The effect of γ-linolenic acid on Polycystic Ovary Syndrome associated Focal Segmental Glomerulosclerosis via TGF-β pathway

Prabhu, Yogamaya D; Bhati, Monica; Vellingiri, Balachandar; Gopalakrishnan, Abilash Valsala

doi:10.1016/j.lfs.2021.119456

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…Among them, linolenic acid has the highest binding energy to the core target AR, and studies have found that linolenic acid plays a role in reversing RF by reducing platelet-reactive protein1 in the kidney and regulating TGF-β signaling in focal segmental glomerulosclerosis. [27] Through the construction of the network and the analysis of network topology parameters, it is found that the ten targets of mitogen-activated protein kinase (MAPK)-1, Akt serine/threonine kinase 1, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, retinoid X receptor alpha, estrogen receptor 1, MAPK14, nuclear receptor subfamily 3 group C member 1, MAP2K1, MAPK11, and AR play an important role in this study. These targets are involved in inflammation, oxidative stress, and cell proliferation and metabolism.…”

Section: Rf Is Characterized By Extensive Fibroblast Activation and E...mentioning

confidence: 87%

Network pharmacology and bioinformatics study on the treatment of renal fibrosis with persicae semen-carthami flos drug pair

Wang

Chang

et al. 2023

Medicine

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To use network pharmacology and bioinformatics technology to reveal the mechanism of persicae semen-carthami flos drug pair in the treatment of renal fibrosis (RF). Compounds in traditional Chinese medicine were obtained through the Herb database. Appropriate compounds and corresponding drug targets were screened out based on the 5 rules of Lipinski and pharmacokinetics. Screening of suitable disease miRNAs by microarray chips in the GEO database. Find differentially expressed genes by analyzing miRNAs. Protein-protein interaction analysis and enrichment analysis of therapeutic targets were performed using String database and Omicshare platform. Molecular docking via the DockThor platform. A total of 28 drug compounds and 228 drug targets were screened in this study. A total of 9 miRNAs and 6649 disease targets were obtained by GEO2R software analysis. Finally, 97 therapeutic targets were obtained. A total of 1124 Gene Ontology enrichment analysis results were obtained. Therapeutic targets play multiple roles in biological processes, molecular functions, and cellular organization. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the persicae semen-carthami flos drug pair played a role in the treatment of RF mainly through calcium signaling pathway, pathways in cancer, cAMP signaling pathway, and other pathways. Molecular docking showed that the traditional Chinese medicine compounds had good binding ability to the target. Persicae semen and carthami flos play a role in the treatment of RF through multiple targets and multiple pathways. It provides ideas and references for follow-up research and new drug development.Abbreviations: AR = androgen receptor, GO = Gene Ontology, KEGG = Kyoto Encyclopedia of Genes and Genomes, MAPK = mitogen-activated protein kinase, RF = renal fibrosis, UUO = unilateral ureteral obstruction.

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Section: Rf Is Characterized By Extensive Fibroblast Activation and E...mentioning

confidence: 87%

Network pharmacology and bioinformatics study on the treatment of renal fibrosis with persicae semen-carthami flos drug pair

Wang

Chang

et al. 2023

Medicine

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“…Activin activates this pathway, which in turn results in the release of the hormone FSH from the ovaries. In the kidneys, activin will lead to the secretion of thrombospondin 1 (TSP1), which has a role in apoptosis and cell growth [ 51 ]. In PCOS, the individual has elevated androgen levels.…”

Section: The Effect Of Androgens On Signaling Pathways In Pcosmentioning

confidence: 99%

“…In PCOS, the individual has elevated androgen levels. This can lead to the damage of the androgen receptors that are located in the kidney, which in turn can result in a number of renal disorders, such as focal segmental glomerulosclerosis (FSGS) [ 51 ]. Elevated androgens damage podocytes in the kidneys and lead to TSP1 hypersecretion, which is associated with FSGS.…”

Section: The Effect Of Androgens On Signaling Pathways In Pcosmentioning

confidence: 99%

The interplay between androgens and the immune response in polycystic ovary syndrome

et al. 2023

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Polycystic ovary syndrome (PCOS) is a metabolic-reproductive-endocrine disorder that, while having a genetic component, is known to have a complex multifactorial etiology. As PCOS is a diagnosis of exclusion, standardized criteria have been developed for its diagnosis. The general consensus is that hyperandrogenism is the primary feature of PCOS and is associated with an array of physiological dysfunctions; excess androgens, for example, have been correlated with cytokine hypersecretion, adipocyte proliferation, and signaling pathway dysregulation. Another key feature of PCOS is insulin resistance, resulting in aberrant glucose and fatty acid metabolism. Additionally, the immune system plays a key role in PCOS. Hyperandrogenism stimulates some immune cells while it inhibits others, thereby disrupting the normal balance of immune cells and creating a state of chronic inflammation. This low-grade inflammation could contribute to infertility since it induces ovarian dysfunction. This dysregulated immune response in PCOS exhibits autoimmunity characteristics that require further investigation. This review paper examines the relationship between androgens and the immune response and how their malfunction contributes to PCOS.

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Valorization Potential of Oil Industry By-Products as Sources of Essential Fatty Acids

et al. 2022

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The oil industry generates a high number of by-products which have the potential to be used in food formulation after they are properly treated. The aim of this study was to evaluate the nutritional potential of 14 different vegetable by-products from the oil industry (flour, meals, and groats) in terms of fatty acid composition and to investigate the effect of theoretical fortification of the bakery products with by-products high in ω-3. Results showed that some of the analyzed samples contain significant amounts of polyunsaturated fatty acids. Organic walnut flour and grape seed flour had a linoleic acid content higher than 60%. By-products obtained from thistle and sesame had a linoleic acid content ranging between 47.32% and 54.72%. Higher linolenic content was obtained for hemp flour (33.22%), red grape seeds meals (33.62%), and golden flax meals (64.65%). By theoretical fortification of wheat and wholemeal flours with high ω-3 by-products in a proportion of 5, 10, and 15%, the ω-3 content increased (2.2- to 22-fold higher) while the ω-6/ω-3 ratio decreased from 5.22 to 0.52–2.86 for wheat flour, and from 16.80 to 0.81–5.53 for wholemeal flour. These vegetable by-products from the oil industry could represent valuable sources of essential fatty acids for the food application, representing valuable ingredients that could be added for the production of functional foods.

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The effect of γ-linolenic acid on Polycystic Ovary Syndrome associated Focal Segmental Glomerulosclerosis via TGF-β pathway

Cited by 3 publications

References 43 publications

Network pharmacology and bioinformatics study on the treatment of renal fibrosis with persicae semen-carthami flos drug pair

Network pharmacology and bioinformatics study on the treatment of renal fibrosis with persicae semen-carthami flos drug pair

The interplay between androgens and the immune response in polycystic ovary syndrome

Valorization Potential of Oil Industry By-Products as Sources of Essential Fatty Acids

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