The effect of β-hydroxy-β-methylbutyrate (HMB) on the morphology of skeletal muscle after concurrent training

Abstract

The aim of the present study was to investigate the effects of β-hydroxy-β-methylbutyrate (HMB) supplementation in association with concurrent training on morphological soleus muscle of rats. Wistar male rats were divided randomly into four groups: Control (C), Supplemented (S), Training (T) and Training + Supplemented (TS). Groups S and TS received 76mg/kg/day of HMB and the training groups (T and TS) were inserted into concurrent training program 3 times/week for 8 weeks. HMB had positive effects either on body composition of the animals or in type II muscle fibers. The concurrent exercise training was able in reducing the total fat mass as well as in increasing the diameter of muscle fibers. Our findings shows that HMB had an anti-catabolic effect with reference to the parameters of volume, weight and morphology of the soleus muscle, and there was a positive interaction between HMB supplementation and concurrent exercise training.

Effect of Concurrent Training and Supplementation with β-Hydroxy- β-Methylbutyirate (HMB) on the Prostate: Alterations in the Androgen Receptor and Inflammation

“…HMB prevented the loss of fat mass and increased the diameter of the cross-sectional area of muscle fibers, contributing to a change in oxidative metabolism and glycolytic fibers (Teixeira et al, 2016). This mechanism specifically increased the phosphorylation of the anabolic Akt/mTOR signaling pathway, and translation activation of the initiation regulators p70S6k, 4E-BP1, and eIF2B.…”

“…The jumping sessions were composed of 4 sets of 10 jumps with 1-minute rest between sets. The overload used was constant, equivalent to 50 % of the body weight of each animal fixed to the anterior chest with a vest shaped specifically for this type of jump (De Mello Malheiro et al, 2009, Teixeira et al, 2016.…”

“…β-hydroxy β-methylbutyrate (HMB) is a leucine metabolite synthesized in the liver and muscle cells from a-ketoisocaproate (KIC), and HMB can be processed in two ways: into cholesterol through HMG-CoA reductase, or into acetyl-CoA through HMG-CoA synthase for power supply (Pimentel et al, 2011). Studies from our laboratory demonstrated that eight-week HMB supplementation associated with concurrent training was effective in promoting skeletal muscle adaptations, such as increased strength and cross-sectional size of muscle fibers (Teixeira et al, 2016). as cortisol (Pimentel et al).…”