The effect of α-terpineol enantiomers on biomarkers of rats fed a high-fat diet

Abstract

Alpha-terpineol is a monoterpenoid found in many essential oils, being widely used in food and household products. In vitro antioxidant and anti-inflammatory activities have already been associated with this alcohol; therefore, this study aimed to check if these properties were also present in vivo, counteracting the oxidant and inflammatory effects of a high-fat diet, as well as if there were differences in the biological activities among the two α-terpineol enantiomers. Thus, this work evaluated the effect of supplementation of α-terpineol enantiomers (at 25, 50 and 100 mg/kg of diet) on biological parameters of diet-induced obese Sprague-Dawley rats. In general, α-terpineol improved the nutritional parameters of rats fed a high-fat diet. The intake of α-terpineol at concentrations !50 mg/kg was able to reestablish the insulin sensibility and reduced (p < 0.05) serum levels of proinflammatory cytokines TNF-α and IL-1β, when compared with the control group. The intake of R-(þ)-and (-)-α-terpineol decreased the TNF-α level by approximately 1.5 and 3.4 times, respectively, when compared with the high-fat group, regardless of the concentration. Moreover, both enantiomers at 50 mg/kg decreased the levels of serum thiobarbituric acid reactive substances (TBARS) by 2.6-4.2 times, while hepatic TBARS were reduced in approximately 1.6 times, regardless of the compound and concentration tested. Further experiments are suggested to confirm the mechanisms and the security of α-terpineol in different experimental models and more extended exposure experiments.

Production, Properties, and Applications of α-Terpineol

“…number 432628) and Fluka's (+)-α-terpineol (≥ 97%, CAS 7785-53-7, Cat. number 83073) with an ee of 16% (for the S-(−)-isomer) and 30% (for the R-(+)-isomer), respectively (Sousa et al 2020). These studies indicate that the potential economically feasible biotechnological processes for the production of α-terpineol are available and also that the enantiospecificity of such a process may be useful to generate enantiomerically enriched products.…”

Lemon Balm and Corn Silk Extracts Mitigate High-Fat Diet-Induced Obesity in Mice

“…Although rosmarinic acid (10–200 mg/kg) and allantoin (5 mg/kg) have been reported to possess beneficial effects in mice fed an HFD [ 36 , 43 , 44 , 45 ], the effective concentrations of rosmarinic acid and allantoin administered directly into animals in the aforementioned references appears too high to be reached in vivo by administration of 200 mg/kg M-LB/CS in the present study. In addition, HPLC chromatogram after eluting LBE and CSE indicated that there were many peaks beyond rosmarinic acid and allantoin, and several phytochemicals contained in two herbs (e.g., ursolic acid, oleanolic acid, caffeic acid, luteolin, rutin, maysin, and α-terpineol) also have potential to alleviate obesity [ 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. Therefore, not only rosmarinic acid/allantoin, but also other phytochemicals existing in LBE and CSE may collaboratively contribute to reduce hypertrophy of the fat tissue and resolve abnormal lipid metabolism.…”

Citrus hystrix Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence

“…α-Terpineol exhibited anti-hypertension, antiproliferation, anti-inflammation, anti-bacteria and antioxidant. Moreover, it could re-establish insulin sensitivity [ 49 , 50 , 51 , 52 , 53 ].…”