The effect of zoledronic acid and denosumab on the mandible and other bones: a 18F-NaF-PET study

Fushimi, Mao; Ohbayashi, Yumiko; Nakai, Fumi; Norikane, Takashi; Yamamoto, Yuka; Nishiyama, Yoshihiro; Miyake, Minoru

doi:10.1007/s11282-022-00594-2

Cited by 5 publications

(1 citation statement)

References 32 publications

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“…One review reported a case of almost normalization of bone metastases uptake after the introduction of denosumab, despite the rise in biological tumor markers ( 48 ). A more recent study compared the uptake intensity of 18 F-NaF between patients treated by denosumab and a control group using cervical vertebrae as a reference, showing no significant difference ( 49 ).…”

Section: Bone Scan: the Historical Cornerstone In The Management Of B...mentioning

confidence: 99%

Nuclear medicine imaging for bone metastases assessment: what else besides bone scintigraphy in the era of personalized medicine?

Ouvrard,

Kaseb,

Poterszman

et al. 2024

Front. Med.

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Accurate detection and reliable assessment of therapeutic responses in bone metastases are imperative for guiding treatment decisions, preserving quality of life, and ultimately enhancing overall survival. Nuclear imaging has historically played a pivotal role in this realm, offering a diverse range of radiotracers and imaging modalities. While the conventional bone scan using 99mTc marked bisphosphonates has remained widely utilized, its diagnostic performance is hindered by certain limitations. Positron emission tomography, particularly when coupled with computed tomography, provides improved spatial resolution and diagnostic performance with various pathology-specific radiotracers. This review aims to evaluate the performance of different nuclear imaging modalities in clinical practice for detecting and monitoring the therapeutic responses in bone metastases of diverse origins, addressing their limitations and implications for image interpretation.

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Section: Bone Scan: the Historical Cornerstone In The Management Of B...mentioning

confidence: 99%