The effect of XPD/ERCC2 Lys751Gln polymorphism on acute leukemia risk: A systematic review and meta-analysis

Liu, Duo; Wu, Dongyuan; Li, Hongbin; Dong, Mei

doi:10.1016/j.gene.2014.01.049

Cited by 18 publications

(17 citation statements)

References 46 publications

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“…XPD (rs13181) polymorphism may influence protein synthesis or affect the stability of mRNA, and it is associated with an inappropriate DNA repair capacity. This in turn might predispose to the genomic instability seen in most cancers, including AML [6]. The role of XPD (rs13181) polymorphism in AML showed controverted results, and some studies associated it with increased disease risk of AML [2,7] and to bad treatment outcome of AML with shorter disease-free survival (DFS) and overall survival (OS) [8,9], while others either failed to find such an association [10] or even associated XPD (rs13181) polymorphism with deceased disease risk of AML [3] and better treatment response [11].…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of xeroderma pigmentosum genes (XPC, XPD, and XPG) and susceptibility to acute leukemia among a sample of Egyptian patients

et al. 2017

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DNA repair systems play a key role in protecting the DNA from damage caused by different endogenous and environmental factors. Genetic polymorphisms in DNA repair genes may lead to increased cancer susceptibility including leukemia. Due to different environmental genetic interactions among each population, the aim of the current study was to assess the association between three genetic polymorphisms of xeroderma pigmentosum complementation group: XPD (rs13181), XPC (rs2228001), and XPG (rs17655) and the susceptibility to acute leukemia in Egypt. The present study included 50 patients with acute leukemia, in addition to 100 normal volunteers as control group. Genotyping for the genes was done by PCR-RFLP technique. The study revealed that patients homovariant for XPD had fourfold increased risk of developing AML (OR = 4.4, P = 0.025) either alone or with variant genotypes of XPC and XPG. No statistically significant association was found between neither individual nor combined polymorphisms and disease risk of ALL in this study. Determination of XPD polymorphism could be considered as molecular markers associated with susceptibility to develop AML.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms of xeroderma pigmentosum genes (XPC, XPD, and XPG) and susceptibility to acute leukemia among a sample of Egyptian patients

et al. 2017

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“…Previous studies have demonstrated that a defect of the DNA repair function is a risk factor for several kinds of cancer, including bladder cancer, acute leukemia, and breast cancer (Yan et al, 2014;Liu et al, 2014). reported a meta-analysis with 11 studies, including 3797 cases and 5094 controls, and showed that polymorphism in ERCC2 rs13181 contributes to bladder cancer susceptibility.…”

Section: Discussionmentioning

confidence: 99%

“…Yan et al (2014) conducted a meta-analysis with 22 studies, and reported that polymorphism in ERCC2 rs13181 significantly increased breast cancer risk. Liu et al (2014) performed a meta-analysis with ten published case-control studies including 1494 cases and 2259 controls, and reported that the ERCC2 rs13181 variant genotype might be a risk factor for acute leukemia. Despite a growing number of epidemiologic studies that have reported an association between the ERCC2 rs13181 polymorphism and the risk of glioma, no significant association was reported between them.…”

Section: Discussionmentioning

confidence: 99%

Association between the ERCC2 rs13181 polymorphism and the risk of glioma: a meta-analysis

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Several studies have focused on the association between the ERCC2 rs13181 polymorphism and glioma risk, but the results were inconclusive. We aimed to conduct a meta-analysis to investigate the role of ERCC2 rs13181 on the risk of glioma. We searched and collated the relevant studies in both Chinese and English through the PubMed, Web of Science, Cochrane Library, and EMBASE databases published through June 1, 2014. A total of 11 studies for ERCC2 rs13181 were selected; these included 3456 glioma cases and 4957 controls. Using fixed-effects model analysis, we found that no significant difference could be identified between the ERCC2 rs13181 polymorphism and the risk of glioma. Subgroup analysis showed that the ERCC2 rs13181 GT and TT genotypes were significantly associated with an increased risk of glioma in the Chinese population [odds ratio (OR) = 1.47, 95% confidence interval (CI) = 1.17-1.85; and OR = 1.50, 95%CI = 1.02-2.22, respectively], but no significant increased risk of glioma was detected with these genotypes in the Caucasian populations. No T.L. Jia et al. 12578©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 12577-12584 (2015) publication bias was identified in this meta-analysis. Our meta-analysis strongly suggested that ERCC2 rs13181 was associated with a higher susceptibility to glioma in the Chinese population.

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“…On the whole, three newly updated meta-analyses revealed that there were no evidence supporting that XPD Lys751Gln polymorphism contributed to prostate cancer (Ma et al, 2013) , colorectal cancer (Zhang et al, 2011) , or gastric cancer (Yin et al, 2013). On the contrary, other large sample meta-analyses proposed a greater risk in hepatocellular carcinoma (Guo et al, 2012), breast cancer (Yan et al, 2014), lung cancer , glioma (Chen et al, 2012), and acute myeloid leukemia (AML) (Liu et al, 2014). For XPD Asp312Asn polymorphism, three meta-analyses proposed a greater risk in prostate cancer (Ma et al, 2013), gastric cancer (Yin et al, 2013), and esophageal cancer (Duan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

XPD Lys751Gln and Asp312Asn Polymorphisms and Susceptibility to Skin Cancer: A Meta-Analysis of 17 Case-control Studies

Zhu¹,

Bao²,

Lin³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Numerous studies have explored the influence of XPD Lys751Gln and/or Asp312Asn polymorphisms on skin cancer susceptibility. However, the results remain inconclusive. To derive a more precise estimation, we conducted a comprehensive search to identify all available published studies and performed a meta-analysis. Materials and Methods: Electronic literature searches of the PubMed, CBM and CNKI databases were performed up to March 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the strength of associations. Results: Seventeen case-control studies were included with a total sample size of 6, 113 cases and 11, 074 controls for the XPD Lys751Gln polymorphism, and 10 studies (3, 840cases and 7, 637 controls) for the XPD Asp312Asn polymorphism were pooled for analysis. Overall, no significant associations were found between the XPD Lys751Gln polymorphism and skin cancer risk in any genetic model. On stratified analysis by tumor type, XPD Lys751Gln polymorphism was not associated with increased risk of non-melanoma skin cancer, but was significantly related with increased risk of cutaneous melanoma (Gln/Gln vs Lys/Lys: OR=1.15, 95%CI=1.02-1.29, p=0.023; dominant model: OR=1.09, 95%CI=1.01-1.18, p=0.036). For the XPD Asp312Asn polymorphism, no significant association with skin cancer risk was observed in overall or subgroup analyses. Conclusions: The present meta-analysis suggests that the XPD Lys751Gln polymorphism may contribute to the risk of cutaneous melanoma from currently available evidence. Further investigations are needed to obtain more insight into possible roles of these two polymorphisms in skin carcinogenesis.

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The effect of XPD/ERCC2 Lys751Gln polymorphism on acute leukemia risk: A systematic review and meta-analysis

Cited by 18 publications

References 46 publications

Polymorphisms of xeroderma pigmentosum genes (XPC, XPD, and XPG) and susceptibility to acute leukemia among a sample of Egyptian patients

Polymorphisms of xeroderma pigmentosum genes (XPC, XPD, and XPG) and susceptibility to acute leukemia among a sample of Egyptian patients

Association between the ERCC2 rs13181 polymorphism and the risk of glioma: a meta-analysis

XPD Lys751Gln and Asp312Asn Polymorphisms and Susceptibility to Skin Cancer: A Meta-Analysis of 17 Case-control Studies

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