The Effect of Whole-Body Irradiation on the Metabolism of 5-Fluorouracil-2- 14 C in the Rat

5-Fluorouracil Concentrations in Rat Plasma, Parotid Saliva, and Bile and Protein Binding in Rat Plasma

“…A decline in the bile-plasma concentration ratio a t higher doses is consistent with a saturable hepatic excretory process. The relative decrease in biliary excretion probably does not contribute greatly to a longer plasma half-life a t higher doses, since 5-fluorouracil is mainly eliminated by urinary excretion (12). In general, low molecular weight compounds are not eliminated primarily uia bile even in rats with ligated renal pedicles (13).…”