The effect of wetting of powder mixture on the preparation of hydrophilic matrix granules with high-shear granulator

Bajdik, János; Baki, Gabriella; Kelemen, András; Pintye‐Hódi, Klára

doi:10.1016/j.cherd.2007.10.003

Cited by 9 publications

(3 citation statements)

References 23 publications

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“…Nevertheless, one drawback of HPMC is the high shear sensitivity reaching with some instability (95). Bajdik et al did some preformulation studies in the research of wetting effect of powder mixture on the preparation of hydrophilic matrix granules with high-shear granulator, revealing that HPMC without other components (Mix100) is not appropriate for high-shear granulation (96).…”

Section: Hydrophilic Matricesmentioning

confidence: 98%

Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms

Tran

Park

et al. 2011

Pharm Res

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In addition to a number of highly soluble drugs, most new chemical entities under development are poorly water-soluble drugs generally characterized by an insufficient dissolution rate and a small absorption window, leading to the low bioavailability. Controlled-release (CR) formulations have several potential advantages over conventional dosage forms, such as providing a uniform and prolonged therapeutic effect to improve patient compliance, reducing the frequency of dosing, minimizing the number of side effects, and reducing the strength of the required dose while increasing the effectiveness of the drug. Solid dispersions (SD) can be used to enhance the dissolution rate of poorly water-soluble drugs and to sustain the drug release by choosing an appropriate carrier. Thus, a CR-SD comprises both functions of SD and CR for poorly water-soluble drugs. Such CR dosage forms containing SD provide an immediately available dose for an immediate action followed by a gradual and continuous release of subsequent doses to maintain the plasma concentration of poorly water-soluble drugs over an extended period of time. This review aims to summarize all currently known aspects of controlled release systems containing solid dispersions, focusing on the preparation methods, mechanisms of action and characterization of physicochemical properties of the system.

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Section: Hydrophilic Matricesmentioning

confidence: 98%

Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms

Tran

Park

et al. 2011

Pharm Res

View full text Add to dashboard Cite

show abstract

“…This method has been utilized in various branches of science and industry, e.g. food [33], environmental management [34], chemistry [35], and pharmaceutical technology [36][37][38][39]. The mathematically determined effects of different factors are compared by means of this technique, this information being very useful for the application of process analytical technology at the heart of which is the acquisition of a deep understanding of the manufacturing process [40].…”

Section: Factorial Designmentioning

confidence: 99%

Development and characterization of matrix pellets prepared by extrusion / sheronization of atenolol

Hamedelniel

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“…food research [51], environmental management [52], chemistry [53] and pharmaceutical technology [54][55][56][57][58] The mathematically determined effects of different factors are compared by means of this technique, this information being very useful for the application of process analytical technology, at the heart of which is the acquisition of a deep understanding of the manufacturing process [59].…”

Section: 4mentioning

confidence: 99%

Optimization of process parameters of coated pellet production

Bölcskei¹

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The effect of wetting of powder mixture on the preparation of hydrophilic matrix granules with high-shear granulator

Cited by 9 publications

References 23 publications

Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms

Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms

Development and characterization of matrix pellets prepared by extrusion / sheronization of atenolol

Optimization of process parameters of coated pellet production

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