The Effect of Western Medicine Therapies on Granulomatous Mastitis: a Meta-analysis

Zhang, Qing; Ding, Boni; Liu, Qian; Wu, Wei; Wen, Yanguang; Gong, Ni

doi:10.1007/s12262-019-01883-7

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Some other studies consider conservative treatments the most effective treatment with the lowest recurrence rate [ 45 , 55 , 56 , 70 ], while others find surgery the most appropriate treatment [ 1 , 60 , 62 , 65 ]. Some studies believe that a combination of conservative and surgical therapy should be administered to decrease the recurrence rate [ 22 , 42 , 59 , 77 ]. In our study, drainage had the highest recurrence rate, while the lowest rate was related to concurrent MTX and steroid treatment.…”

Section: Discussionmentioning

confidence: 99%

Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis

Sarmadian,

Safi,

Sarmadian

et al. 2024

Eur J Med Res

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Background Granulomatous mastitis (GM) is a rare, benign, inflammatory breast disease with an unknown etiology that predominantly affects women of reproductive age. The definitive treatment of GM is currently controversial; an appropriate therapeutic strategy has yet to be identified, and the disease’s high recurrence rate remains. This study aims to determine the recurrence rate for each GM treatment strategy to identify the most appropriate treatment modality. Methods The search for relevant articles was undertaken using three international databases, including Medline, Scopus, and Web of Science. Articles published in English until the end of 2021 evaluating the recurrence rate of GM were included. Using Stata 13.0, the pooled incidence and 95% confidence interval (CI) for the recurrence rate were determined. Results Sixty-five eligible studies were included in our study. The recurrence rates of systemic steroid use, topical steroid use, antibiotic use, methotrexate use, observation, drainage, excision, antibiotic use and surgery, steroid use and surgery, antibiotic and steroid use, methotrexate and steroid use were 24% (95% CI: 21–27%), 11% (95% CI: 6–21%), 18% (95% CI: 14–22%), 13% (95% CI: 7–22%), 11% (95% CI: 7–17%), 65% (95% CI: 50–78%), 13% (95% CI: 10–16%), 23% (95% CI: 14–36%), 7% (95% CI: 5–11%), 11% (95% CI: 6–18%), and 4% (95% CI: 2–8%), respectively. Drainage had the highest recurrence rate, while combined methotrexate and steroid treatment had the lowest rate. Conclusion The optimal treatment strategy for GM depends on the disease’s severity, consequences, and the patient's features. The study results indicate that combination therapy is preferable for minimizing the risk of relapse and reducing treatment complications.

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Section: Discussionmentioning

confidence: 99%

Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis

Sarmadian,

Safi,

Sarmadian

et al. 2024

Eur J Med Res

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“…To date, surgery is one of the best treatment options with a low recurrence rate and high complete remission (CR) rate. [24,31] The meta-analysis of the CR and recurrence rate revealed overall estimates of 94.5% (95% CI 88.9%, 98.3%) and 4.0% (95% CI 1.5%, 8.4%), respectively. [24] The CR rates and recurrence rate of IGM cases treated with oral steroids ranged from 30.8% [32] to 100.0% [33,34] and from 0.0% [34] to 46.2% [35], respectively.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of local steroid injection for the treatment of breast-limited idiopathic granulomatous mastitis: A randomized controlled clinical trial study

Karami

Zangouri

Habibagahi

et al. 2022

Preprint

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Background: Idiopathic granulomatous mastitis (IGM) is a rare non-specific inflammatory breast disease and is usually considered a kind of autoimmune disease. There are several controversies regarding its standard treatment. We aimed to evaluate the efficacy of local corticosteroid injection for the treatment of breast-limited idiopathic granulomatous mastitis.Methods: This randomized prospective clinical trial study evaluated the clinical response rate of local steroid injection to treat breast-limited IGM in women. The subjects received local steroid injection of long-action (LA) Betamethasone combined with standard systemic treatments (prednisolone, Methotrexate) (Combine therapy group), standard systemic treatments alone (Systemic group), or local steroid injection alone (LA Betamethasone, Injection group). Clinical benefits and recurrence rates were compared in the three groups.Results: All of the patients were women, and their mean age was 34 years. The excellent clinical or radiological response was observed in 20/31 (64.5%), 24/38 (63.1%), and 17/30 (56.6 %) patients in the injection, combined, and systemic therapy groups, respectively. During the follow-up of 10 months in patients who received local steroid injection alone, recurrence was observed in six patients (16.4%, 6/31), and no side effects or injection steroid-related complications occurred. The local recurrence rate in systemic and combined therapy groups were 3.3 % (1/30) and 13.2 % (5/38) patients, respectively.Conclusions: Our findings suggest that local betamethasone LA injection in breast limited IGM is as successful as current standard treatment and shortens the complete healing time compared to treatment with systemic therapy. Short time recurrence rate was not statistically significant among the groups. Local injection could be a beneficial option in the treatment of IGM. Trial registration: The trial registry number was IRCT20200608047694N1. Registration date: 2020-07-21.

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The Effect of Western Medicine Therapies on Granulomatous Mastitis: a Meta-analysis

Abstract: Materials and Methods Inclusion Criteria Study Types(1) Randomized controlled trials (RCTs) and non-randomized controlled trial; (2) studies with a specific inclusion criteria * Boni Ding

Cited by 2 publications

References 35 publications

Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis

Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis

The effectiveness of local steroid injection for the treatment of breast-limited idiopathic granulomatous mastitis: A randomized controlled clinical trial study

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