The Effect of Vitamins B on Improving the Symptoms of Migraine: An Overview

Nematgorgani, Shiva; Gholi, Zahra; Jahromi, Soodeh Razeghi; Togha, Mansoureh; Karimzadeh, Fariba

doi:10.29252/shefa.8.2.119

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…Several studies show that some B vitamins can improve migraine headaches, especially frequency and severity. Dietary supplements B vitamins can effectively prevent or reduce the various symptoms of migraine headaches [ 37 ]. Also, in other studies, there was a decrease in mean MMD in the placebo-treated group, which varied depending on the route of medication, the type of migraine, and the effect of previous treatments [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of agomelatine on headache severity and frequency in episodic migraine without aura; a parallel randomized controlled trial study

Farzin,

Kheiltash,

Tafakhori

et al. 2024

BMC Neurol

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Background Migraine is a headache disorder that affects public health and reduces the patient’s quality of life. Preventive medication is necessary to prevent acute attacks and medication overuse headaches (MOH). Agomelatine is a melatonin antagonist. Aims This study aimed to determine the effectiveness of agomelatine on the severity and frequency of migraine attacks. Methods The study is a parallel randomized controlled trial with two groups of intervention and control. 400 patients were evaluated. Eligible individuals, including those with episodic migraine headaches without aura between the ages of 18 and 60 years who did not receive preventive treatment beforehand, were enrolled. Also, patients did not receive any specific medications for other diseases. Among these, 100 people met the inclusion criteria and entered the study. These subjects were randomly assigned to one of the two groups. The intervention group received 25 mg of agomelatine daily and the control group received B1. In this study, the effect of agomelatine on the frequency and severity of attacks, mean monthly migraine days (MMD), and migraine disability assessment (MIDAS), were assessed. The study was triple-blind and after three months, a post-test was performed. Data were analyzed using SPSS software. Results A total of 100 patients were randomly assigned to either intervention or control groups. The prescriber physician and the data collector did not know about the allocation of patients to groups. Before the intervention, there was no significant difference in the headache frequency per month (t=-0.182, df = 98, p = 0.85), mean MMD (p = 0.17), headache severity (p = 0.076), and MIDAS (p = 0.091). After the study, there was a significant difference between the two groups in terms of the headache frequency per month (p = 0.009), and mean of MMD (p = 0.025). There was also a significant difference between pretest and posttest in two groups in the headache severity (p < 0.001) and MIDAS (p < 0.001). Conclusion Agomelatine can be used as a preventive medication for migraine without aura. It is suggested that agomelatine be studied in comparison with other preventive drugs for patients with migraine. Trial retrospectively registration Trial Retrospectively registration= IRCT20230303057599N1. Date: 2023-5-24 The present study is a residency thesis approved by the Tehran University of Medical Sciences.

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Section: Discussionmentioning

confidence: 99%

The effectiveness of agomelatine on headache severity and frequency in episodic migraine without aura; a parallel randomized controlled trial study

Farzin,

Kheiltash,

Tafakhori

et al. 2024

BMC Neurol

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“…Treatment of EM is critical because it can progress to chronic migraine and increase migraine disability. 43 , 44 …”

Section: Discussionmentioning

confidence: 99%

B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial

Nematgorgani¹,

Razeghi-Jahromi²,

Jafari³

et al. 2022

CJN

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Background: The B vitamins can potentially help prevent migraine. This study was designed to examine the effects of supplementation with thiamine (B1), pyridoxine (B6), cobalamin (B12), folic acid (B9), and a combination of these vitamins on women with episodic migraine (EM). Methods: This study was a double-blind, placebo-controlled, randomized, clinical trial conducted on 120 women with EM. The participants were divided into the 6 groups of B1 (n = 20), B6 (n = 20), B12 (n = 20), B9 (n = 20), vitamin B complex (n = 20), and placebo (n = 20). Subjects received 1 capsule daily for 12 weeks. As part of the baseline and post-intervention phases, paper-based headache diaries were used to record the number of abortive drugs consumed and the frequency of headache attacks, and the Migraine Disability Assessment Questionnaire (MIDAS) was used to assess migraine disability. Results: A 16-week study on women with EM revealed that the mean changes in the frequency of headache attacks decreased significantly in all vitamin groups in comparison with the placebo group (P < 0.001). In contrast to the placebo, there was also a significant improvement in the migraine disability score in each vitamin group (P < 0.001). The 12-week supplementation with vitamins B9, B1, B6, B12, and B complex also brought on a significant decrease in the use of abortive drugs compared to the placebo group (P = 0.032). Conclusion: The results of this study showed that B1, B6, B12, and B9, and a combination of these vitamins could be effective as an adjuvant in treatment and prophylaxis of EM. Further large trials with long-term follow-ups will be required to confirm our results.

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An Investigation into the Effects of Water- and Fat-Soluble Vitamins in Alzheimer's and Parkinson's Diseases

Shahverdi,

Sourani,

Sargolzaie

et al. 2023

Shefaye Khatam

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The Effect of Vitamins B on Improving the Symptoms of Migraine: An Overview

Cited by 4 publications

References 38 publications

The effectiveness of agomelatine on headache severity and frequency in episodic migraine without aura; a parallel randomized controlled trial study

The effectiveness of agomelatine on headache severity and frequency in episodic migraine without aura; a parallel randomized controlled trial study

B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial

An Investigation into the Effects of Water- and Fat-Soluble Vitamins in Alzheimer's and Parkinson's Diseases

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