The effect of vitamin–mineral supplementation on CRP and IL-6: A systemic review and meta-analysis of randomised controlled trials

Sun, Changhao; Li, Y.; Zhang, Y.-B.; Wang, Fan; Zhou, Xifa

doi:10.1016/j.numecd.2009.12.014

Cited by 11 publications

(8 citation statements)

References 32 publications

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“…A meta-analysis of the results of supplementation trials with antioxidant nutrients conducted in healthy populations concluded that supplementation did not significantly reduce CRP levels [29]. These results are in line with the fact that supplementation in itself was not associated with CRP in our study.…”

Section: Discussionsupporting

confidence: 89%

“…Besides the observational studies, some trials have investigated the effect of supplementation with antioxidant nutrients on inflammatory biomarkers, with somewhat inconsistent results [29,30,31,32,33,34,35,36]. A meta-analysis of the results of supplementation trials with antioxidant nutrients conducted in healthy populations concluded that supplementation did not significantly reduce CRP levels [29].…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant Status and the Risk of Elevated C-Reactive Protein 12 Years Later

et al. 2014

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Background/Aims: Low-grade inflammation is an independent risk factor for cardiovascular disease. Relationships between the antioxidant status and inflammatory biomarkers could give new insights into cardiovascular disease prevention. We investigated long-term associations between the antioxidant nutrient (vitamin C, α-tocopherol, β-carotene) status and C-reactive protein (CRP) in a population-based cohort. Methods: Subjects included in the French SU.VI.MAX trial study who had available data on baseline (1994-1995) blood nutrient concentrations and CRP measurements 12 years later (2007-2009) were included. Associations between baseline antioxidant circulating concentrations and elevated CRP (>3 mg/l) were investigated in multivariate logistic regression models. Subgroup analyses were performed according to gender, supplementation group of the initial trial, smoking status, and alcohol intake. Results: Serum α-tocopherol (n = 2,060) and vitamin C (n = 1,719) concentrations [odds ratio (OR) and 95% confidence interval (95% CI) quintile 5 vs. 1: OR 1.10 (95% CI 0.71-1.73), p for trend = 0.533, vs. OR 0.79 (95% CI 0.48-1.29), p for trend = 0.121, respectively] were not associated with elevated CRP concentrations. The β-carotene status (n = 2,048) was inversely associated with elevated CRP [adjusted OR quintile 5 vs. 1: OR 0.61 (95% CI 0.38-0.98), p for trend = 0.01]. Subgroup analyses showed that associations were stronger in women (p for trend = 0.004), never smokers (p for trend = 0.009) and subjects in the supplementation group (p for trend = 0.002). Conclusions: Our results suggest that the β-carotene status may be inversely associated with low-grade inflammation in the long term.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Antioxidant Status and the Risk of Elevated C-Reactive Protein 12 Years Later

et al. 2014

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“…For the meta‐analysis, we calculated the mean change of plasma concentrations of selected cytokines from baseline to follow‐up for each intervention and control group, if not reported, and the SD of delta concentration was estimated as previously described . All values were converted to pg/mL, if necessary.…”

Section: Methodsmentioning

confidence: 99%

Effect of flavonoids on circulating levels of TNF-α and IL-6 in humans: A systematic review and meta-analysis

Peluso

Raguzzini

Serafini

2013

Mol. Nutr. Food Res.

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Epidemiological or in vitro evidence suggests a potential role for flavonoids as anti-inflammatory agents; we investigated the effect of flavonoids-rich foods or supplements on tumor necrosis factor- alpha (TNF-α) and interleukin-6 (IL-6) in long-term placebo-controlled human intervention trials. From 110 human intervention studies selected (MEDLINE, EMBASE, CHORANE, and FSTA databases), 32 long-term placebo-controlled trials were suitable for meta-analysis. After sensitivity analysis, seven studies imputed of bias were excluded and 25 studies were analyzed (TNF-α, n = 2404; IL-6, n = 2174). Levels of TNF-α decreased after flavonoid consumption in the fixed model only (mean difference (MD) (95% CI): -0.098 (-0.188, -0.009), p = 0.032), but metaregression results showed that neither higher dose, nor a longer duration of intervention were associated with a greater effect size. Subgroup analysis did not reveal any significant effect for quercetin and soy, but other sources (red wine, pomegranate, and tea extracts) showed a significant effect size both in fixed (MD (95% CI): TNF-α -0.449 (-0.619, -0.280), p < 0.001; IL-6 -0.346 (-0.612, -0.079), p = 0.011) and random (MD (95% CI): TNF-α -0.783 (-1.476, -0.090), p = 0.027; IL-6, -0.556 (-1.062, -0.050), p = 0.031) effect models. High-quality placebo-controlled trials are needed in order to identify flavonoids as the active ingredients.

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“…Epidemiological studies have demonstrated that nutrition in early life is associated with MetS, obesity, and diabetes later in adulthood; this is known as the theory of "developmental origins of health and disease" proposed by Barker in the early 1990s. [44][45][46][47] Both maternal undernutrition and overnutrition during pregnancy are correlated with suboptimal infant birth weight (underweight or overweight), altered postnatal growth (eg, rapid catch-up growth among low-birth-weight infants), and an increased risk of adulthood obesity and MetS. [44][45][46] Low birth weight is associated with reduced fetal and adulthood muscle mass and consequently increased risks of MetS, T2DM, and CVD later in life.…”

Section: Nutrition In Early Lifementioning

confidence: 99%

“…[44][45][46][47] Both maternal undernutrition and overnutrition during pregnancy are correlated with suboptimal infant birth weight (underweight or overweight), altered postnatal growth (eg, rapid catch-up growth among low-birth-weight infants), and an increased risk of adulthood obesity and MetS. [44][45][46] Low birth weight is associated with reduced fetal and adulthood muscle mass and consequently increased risks of MetS, T2DM, and CVD later in life. This is in part due to the fact that skeletal muscle is critical to maintaining resting energy expenditure and whole-body insulin sensitivity.…”

Section: Nutrition In Early Lifementioning

confidence: 99%

Role of nutrients in metabolic syndrome: a 2017 update

Kern¹,

Mitmesser²

2018

NDS

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Metabolic syndrome (MetS) and its associated chronic disorders including cardiovascular disease and type 2 diabetes are public health concerns in the USA and worldwide. "Good health is an investment in economic growth," and nutrition is one of the recommended preventive measures to manage these chronic diseases. However, it is unclear whether and to what extent nutrients could be beneficial to the improvement of MetS. To help answer this question, we performed a literature review of the emerging human data on single nutrients and MetS: PubMed was searched from January 1, 2005 to June 12, 2017, using a combination of the following keywords: "nutrient" OR "vitamin" OR "mineral" OR "nutraceutical" AND "metabolic syndrome." The summary of literature comprises macronutrients (proteins/amino acids, fatty acids, fibers, and sugar), micronutrients (antioxidant vitamins, vitamin D, folate, magnesium, and chromium), polyphenols (flavonoids, resveratrol, isoflavones, and chlorogenic acid), and other compounds (α-lipoic acid, benfotiamine, fucoxanthin, policosanol, and stanols). Bearing a holistic approach in mind, we also highlighted select lifestyle factors that may contribute to MetS (such as circadian rhythm and nutrition in early life). Observational studies have generated positive evidence supporting the beneficial role of numerous nutrients in MetS. Although the results of some clinical trials are consistent with the observational data, causality is not always clear or consistent across trials. Both nutrition and health are complex and dynamic systems with a hierarchical nature. When we design confirmatory trials to investigate nutrient(s) and MetS, instead of the traditional "single-nutrient" concept, it is worth considering a holistic approach to integrate groups or classes of nutrients, lifestyle influencers (ie, diet and physical activity), and population relevance (ie, healthy, at-risk, or diseased).

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The effect of vitamin–mineral supplementation on CRP and IL-6: A systemic review and meta-analysis of randomised controlled trials

Cited by 11 publications

References 32 publications

Antioxidant Status and the Risk of Elevated C-Reactive Protein 12 Years Later

Antioxidant Status and the Risk of Elevated C-Reactive Protein 12 Years Later

Effect of flavonoids on circulating levels of TNF-α and IL-6 in humans: A systematic review and meta-analysis

Role of nutrients in metabolic syndrome: a 2017 update

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